Detailed information NTG0190125

Bioinformatically predicted

Overview

• Name: dsbA2
• Type: Machinery gene
• Locus tag: A6L27_RS05140
• Genome accession: NZ_CP016648
• Coordinates: 991746..992441 (+)
• Length: 231 a.a.
• NCBI ID: WP_002215704.1
• Uniprot ID: Q7DDR6
• Organism: Neisseria meningitidis strain M09293
• Function: DNA binding and uptake; interact with PilQ (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	990916..1008838	991746..992441	within	0

Gene organization within MGE regions

Location: 990916..1008838

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6L27_RS05135 (A6L27_05135)	-	990916..991575 (+)	660	WP_002218694.1	NYN domain-containing protein	-
A6L27_RS05140 (A6L27_05140)	dsbA2	991746..992441 (+)	696	WP_002215704.1	thiol:disulfide interchange protein DsbA/DsbL	Machinery gene
A6L27_RS05145 (A6L27_05145)	ffh	992772..994142 (-)	1371	WP_002221448.1	signal recognition particle protein	-
A6L27_RS05150 (A6L27_05150)	-	994362..995168 (+)	807	WP_002221447.1	cytochrome C assembly family protein	-
A6L27_RS05190 (A6L27_05190)	comE	1000967..1001431 (+)	465	WP_025463168.1	ComEA family DNA-binding protein	Machinery gene
A6L27_RS05195 (A6L27_05195)	-	1001543..1001749 (+)	207	WP_025461473.1	hypothetical protein	-
A6L27_RS05205 (A6L27_05205)	-	1002307..1002960 (+)	654	WP_002241060.1	IS1595 family transposase	-
A6L27_RS05210 (A6L27_05210)	-	1003125..1003334 (+)	210	Protein_981	transposase	-
A6L27_RS05215 (A6L27_05215)	-	1003316..1003573 (-)	258	WP_002241061.1	membrane protein	-
A6L27_RS05220 (A6L27_05220)	aroG	1004240..1005295 (+)	1056	WP_002216371.1	3-deoxy-7-phosphoheptulonate synthase AroG	-
A6L27_RS05225 (A6L27_05225)	-	1005363..1005851 (+)	489	WP_002216373.1	dihydrofolate reductase	-
A6L27_RS05230 (A6L27_05230)	-	1006201..1006677 (-)	477	WP_002241062.1	CYTH domain-containing protein	-
A6L27_RS05235 (A6L27_05235)	-	1006689..1007117 (-)	429	WP_002261574.1	CopD family protein	-
A6L27_RS05245 (A6L27_05245)	-	1007229..1007474 (+)	246	WP_002248225.1	hypothetical protein	-

Sequence

Protein

• Length: 231 a.a.
• Molecular weight: 25419.90 Da
• Isoelectric Point: 5.1502

>NTDB_id=190125 A6L27_RS05140 WP_002215704.1 991746..992441(+) (dsbA2) [Neisseria meningitidis strain M09293]
MKLKTLALTSLTLLALAACSKQAETSVPADSAQSSSSAPAAPAELNEGVNYTVLSTPIPQQQAGKIEVLEFFGYFCPHCA
HLEPVLSEHIKTFKDDTYMRREHVVWGDEMKPLARLAAAVEMAGESDKANSHIFDAMVNQKINLADTDTLKKWLSEQTAF
DGKKVLAAFEAPESQARAAQMEELTNKFQISGTPTVIVGGKYQVEFKDWQSGMTTIDQLVDKVREEQKKPQ

Nucleotide

• Length: 696 bp

>NTDB_id=190125 A6L27_RS05140 WP_002215704.1 991746..992441(+) (dsbA2) [Neisseria meningitidis strain M09293]
ATGAAACTGAAAACCTTAGCTTTGACTTCATTGACCCTGTTGGCATTGGCCGCTTGTAGCAAACAGGCTGAAACCAGTGT
TCCGGCAGACAGCGCCCAAAGCAGCTCATCTGCTCCGGCAGCCCCTGCTGAGTTGAACGAAGGTGTGAACTACACTGTAT
TGTCTACGCCTATTCCGCAACAGCAGGCCGGTAAAATCGAAGTATTGGAATTTTTCGGCTACTTCTGCCCGCATTGCGCC
CATCTTGAGCCGGTCTTGAGCGAGCACATCAAAACGTTTAAAGACGATACCTATATGCGCCGGGAGCATGTCGTGTGGGG
TGATGAAATGAAACCTTTGGCACGTTTGGCGGCCGCAGTGGAAATGGCCGGTGAATCAGATAAAGCCAACAGCCATATTT
TCGATGCGATGGTTAATCAAAAAATCAATCTGGCCGATACCGATACCCTGAAAAAATGGCTGTCCGAGCAAACAGCGTTT
GACGGCAAAAAAGTATTGGCTGCATTTGAGGCTCCTGAAAGCCAAGCGCGTGCGGCTCAAATGGAAGAGTTGACCAATAA
ATTCCAAATCAGCGGCACACCGACTGTGATTGTCGGCGGCAAATACCAAGTTGAATTTAAAGACTGGCAGTCTGGTATGA
CCACGATTGACCAGTTGGTGGATAAAGTACGCGAAGAGCAGAAAAAGCCGCAATAA

Domains

Predicted by InterproScan.

• Thioredoxin (Thioredoxin_4) (65-212)

3D structure

• AlphaFold DB: Q7DDR6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dsbA2	Neisseria meningitidis MC58	100	100	1
dsbA1	Neisseria meningitidis MC58	71.245	100	0.719