Detailed information NTG0188019

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FORC40_RS09690
• Genome accession: NZ_CP016398
• Coordinates: 1916920..1917963 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FORC_040
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1911920..1922963

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FORC40_RS09660 (FORC40_1713)	-	1912342..1913598 (-)	1257	WP_001789555.1	aminopeptidase	-
FORC40_RS09665 (FORC40_1714)	-	1913601..1913801 (-)	201	WP_000180460.1	DUF1128 family protein	-
FORC40_RS09670 (FORC40_1715)	-	1913948..1914412 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FORC40_RS09675 (FORC40_1716)	-	1914419..1914694 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FORC40_RS09680 (FORC40_1717)	-	1914972..1916189 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
FORC40_RS09685 (FORC40_1718)	vraR	1916301..1916930 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
FORC40_RS09690 (FORC40_1719)	vraS	1916920..1917963 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FORC40_RS09695 (FORC40_1720)	liaF	1917960..1918661 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FORC40_RS09700 (FORC40_1721)	-	1918676..1919062 (-)	387	WP_001110179.1	hypothetical protein	-
FORC40_RS09705 (FORC40_1722)	map	1919279..1920037 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
FORC40_RS09710 (FORC40_1723)	-	1920565..1921551 (+)	987	WP_000999714.1	FUSC family protein	-
FORC40_RS09715 (FORC40_1724)	-	1921982..1922395 (-)	414	WP_025173836.1	hypothetical protein	-
FORC40_RS09720	-	1922424..1922534 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=188019 FORC40_RS09690 WP_001017131.1 1916920..1917963(-) (vraS) [Staphylococcus aureus strain FORC_040]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=188019 FORC40_RS09690 WP_001017131.1 1916920..1917963(-) (vraS) [Staphylococcus aureus strain FORC_040]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1