Detailed information NTG0183265

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: LLUC77_RS05440
• Genome accession: NZ_CP015906
• Coordinates: 1030538..1032013 (+)
• Length: 491 a.a.
• NCBI ID: WP_010906048.1
• Uniprot ID: A0A2A9ICZ0
• Organism: Lactococcus lactis subsp. lactis strain UC77
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1025538..1037013

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC77_RS05405 (LLUC77_1695)	-	1025800..1026636 (+)	837	WP_003130766.1	metallophosphoesterase	-
LLUC77_RS05410 (LLUC77_1694)	-	1026697..1027227 (+)	531	WP_003130764.1	CHAP domain-containing protein	-
LLUC77_RS05415 (LLUC77_1693)	-	1027712..1028074 (+)	363	WP_010906050.1	TIGR02328 family protein	-
LLUC77_RS05420 (LLUC77_1692)	-	1028156..1028620 (+)	465	WP_003130761.1	hypothetical protein	-
LLUC77_RS05425 (LLUC77_1691)	-	1028776..1029021 (+)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
LLUC77_RS05430 (LLUC77_1690)	-	1029152..1029682 (+)	531	WP_003130758.1	DUF177 domain-containing protein	-
LLUC77_RS05435 (LLUC77_1689)	covR	1029838..1030530 (+)	693	WP_003130756.1	response regulator transcription factor	Regulator
LLUC77_RS05440 (LLUC77_1688)	covS	1030538..1032013 (+)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
LLUC77_RS05445 (LLUC77_1687)	-	1032196..1033437 (+)	1242	WP_003130753.1	ammonium transporter	-
LLUC77_RS05450 (LLUC77_1686)	-	1033569..1033910 (+)	342	WP_010906046.1	P-II family nitrogen regulator	-
LLUC77_RS05455 (LLUC77_1685)	murD	1034401..1035753 (+)	1353	WP_003130748.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 491 a.a.
• Molecular weight: 56195.08 Da
• Isoelectric Point: 4.8253

>NTDB_id=183265 LLUC77_RS05440 WP_010906048.1 1030538..1032013(+) (covS) [Lactococcus lactis subsp. lactis strain UC77]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Nucleotide

• Length: 1476 bp

>NTDB_id=183265 LLUC77_RS05440 WP_010906048.1 1030538..1032013(+) (covS) [Lactococcus lactis subsp. lactis strain UC77]
ATGAAAAAACTATTTACTTTCAATAAGAAAAAAGAGACGGTAGAGGAAAGTTCGGCTAAGCGGTCTATCATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTTTGTTTGCTACTTTGACTTATCAATTGACAATCAGTTCTT
TTATTAAAGAAGAACAACAATTATTAACTCGCTCTATGGATAGTGTTGAGGAAGTCTTAGAAAAAGCAGATGCTCCTTTG
AATTCATCGAATTTGAACACATATATTGAAGCGACATCAAAGATTCAAAATGGTGAGTCTGAAGGAATGAGTTTGGGTAG
TATCATTGGGACACGGAAAGCATTTTATATTTATGACTTAAATCATAAATTATTGTATTCAACGAATCGACATACTTTTG
GTTTTCAGAATCAGGCTAATAATGAAATGAAAGAGATTCGGGGAGAAAATCCAGGTTATTTAGTTCAGAGAAAAATTATT
TCTAAGTCAACAGGACAAGTTGTGGGATACTTACAGGCTTTTTATGATACGACGACTTATCATCGAATTTCTAATCTTCT
TTTGATTGTCTTGTTAATTTTAGAAATTGTTGCCTTGATTGTCGCTCAGTTGATTGGTTATTTCATGGCTAATTACTTTA
TGAAACCATTGGAAAAACTTTATCAGGGCATGCAAGAAATGGCAAATGATCCAACAAATGATTTTGAACCGATTGAAATT
CAAAGTGGAGATGAAATCGAAGAGTTGGCTCATGTTTACAATGATATGATGTTGAAGATGAAGGCATATCTTGAACAGCA
AAATCGCTTTGTTTCTGATGTTTCTCATGAATTAAGAACACCTTTAGCTGTCTTGGATGGACATATTAACTTGTTGAATC
GATGGGGGAAAAATGATCCAGAAGTATTAGATGAATCTTTGCAGGCAAGTTTAGATGAAGTTGATCGAATGAAGAAAATG
CTTGAGGAGATGTTGGCTCTTGCTCGCCTTGAAAATGTTGACTTATCAAGTGAAGAACTGGATTGTGATGTTGGAAAAGT
TTGTAATCGGGCCCTTAAGAATTTTCAGCTTTTGCATGATGATTTTGAAATAGTGCTTGATAACCGGCTTATTTATCCCA
CTCATGCGCGAATTTCAGAAAATCATTTTGAACAAGGGTTACGAATTCTGTTAGATAATGCTGCTAAATACTCTCCTGAT
GATCGTAAAGAAATCGTGATTACTGTTTCTGAGGATGAACAGTTTGTGATTACGAGTGTATCTGACAAAGGAATTGGAAT
TTCAGAAGAAGATATTAATCATCTTTTTGAGCGTTTCTTTAGAGCGGACAAGGCTCGCAATCGAGAAATTGGTGGAACTG
GTTTAGGTTTATCAATTTTAGCTCGATTGGCAGAAAATTATCAAGGGGAAATTGAGGTAAATTCAGAACTGGGTCTTGGT
TCAACTTTTACACTAAAATTCCCGAAAATAAAATAA

Domains

Predicted by InterproScan.

• ArlS sensor domain (ArlS_N) (54-185)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (380-489)

• HAMP domain (HAMP) (208-258)

• His Kinase A (phospho-acceptor) domain (HisKA) (267-332)

3D structure

• AlphaFold DB: A0A2A9ICZ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1