Detailed information NTG0183004

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LLJM2_RS11405
• Genome accession: NZ_CP015900
• Coordinates: 2215377..2216408 (-)
• Length: 343 a.a.
• NCBI ID: WP_011677213.1
• Uniprot ID: A0A166ZHD8
• Organism: Lactococcus cremoris strain JM2
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2210377..2221408

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLJM2_RS11385 (LLJM2_2232)	-	2212064..2212273 (-)	210	WP_011677212.1	hypothetical protein	-
LLJM2_RS11390 (LLJM2_2234)	-	2212561..2213451 (+)	891	WP_064305155.1	IS982-like element IS982B family transposase	-
LLJM2_RS11395 (LLJM2_2235)	kwcM	2213558..2214877 (-)	1320	WP_014573366.1	KxxxW cyclic peptide radical SAM maturase	-
LLJM2_RS11400 (LLJM2_2236)	-	2214945..2215058 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
LLJM2_RS11405 (LLJM2_2237)	sepM	2215377..2216408 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator
LLJM2_RS11410 (LLJM2_2238)	coaD	2216392..2216892 (-)	501	WP_011677214.1	pantetheine-phosphate adenylyltransferase	-
LLJM2_RS11415 (LLJM2_2239)	rsmD	2216940..2217479 (-)	540	WP_031286167.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LLJM2_RS11420 (LLJM2_2240)	-	2217650..2218870 (-)	1221	WP_011677216.1	MFS transporter	-
LLJM2_RS11425 (LLJM2_2241)	lmrP	2218954..2220179 (-)	1226	Protein_2210	multidrug efflux MFS transporter LmrP	-
LLJM2_RS11430 (LLJM2_2242)	-	2220367..2220861 (+)	495	WP_021164846.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37398.03 Da
• Isoelectric Point: 9.8499

>NTDB_id=183004 LLJM2_RS11405 WP_011677213.1 2215377..2216408(-) (sepM) [Lactococcus cremoris strain JM2]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=183004 LLJM2_RS11405 WP_011677213.1 2215377..2216408(-) (sepM) [Lactococcus cremoris strain JM2]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTATGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A166ZHD8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.49