Detailed information NTG0182905

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LL275_RS11915
• Genome accession: NZ_CP015897
• Coordinates: 2357948..2358976 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis subsp. lactis strain 275
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2352948..2363976

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LL275_RS11890 (LL275_2300)	-	2353234..2353731 (-)	498	WP_003132662.1	nitroreductase family protein	-
LL275_RS11895 (LL275_2301)	-	2353718..2353927 (-)	210	WP_003132661.1	hypothetical protein	-
LL275_RS11900 (LL275_2302)	-	2353924..2354751 (-)	828	WP_014570829.1	radical SAM protein	-
LL275_RS11905 (LL275_2303)	-	2354744..2356867 (-)	2124	WP_003132659.1	radical SAM protein	-
LL275_RS11910 (LL275_2304)	-	2356970..2357827 (-)	858	WP_003132658.1	Rgg/GadR/MutR family transcriptional regulator	-
LL275_RS11915 (LL275_2305)	sepM	2357948..2358976 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
LL275_RS11920 (LL275_2306)	coaD	2358963..2359460 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
LL275_RS11925 (LL275_2307)	rsmD	2359508..2360047 (-)	540	WP_003132655.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LL275_RS11930 (LL275_2308)	-	2360218..2361438 (-)	1221	WP_081144368.1	MFS transporter	-
LL275_RS11935 (LL275_2309)	lmrP	2361522..2362746 (-)	1225	Protein_2303	multidrug efflux MFS transporter LmrP	-
LL275_RS11940 (LL275_2310)	-	2362934..2363428 (+)	495	WP_012898649.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=182905 LL275_RS11915 WP_003132657.1 2357948..2358976(-) (sepM) [Lactococcus lactis subsp. lactis strain 275]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=182905 LL275_RS11915 WP_003132657.1 2357948..2358976(-) (sepM) [Lactococcus lactis subsp. lactis strain 275]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACAAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGAAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTCCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTACAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGTGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
GACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTGGTGCCTGACTCAGGCACCAAAAAAGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCCGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491