Detailed information NTG0182858

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LL158_RS10770
• Genome accession: NZ_CP015894
• Coordinates: 2122000..2123031 (-)
• Length: 343 a.a.
• NCBI ID: WP_011677213.1
• Uniprot ID: A0A166ZHD8
• Organism: Lactococcus cremoris strain 158
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2117000..2128031

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LL158_RS10740 (LL158_2070)	-	2118203..2118700 (-)	498	WP_011677211.1	nitroreductase family protein	-
LL158_RS10745 (LL158_03445)	-	2118687..2118896 (-)	210	WP_011677212.1	hypothetical protein	-
LL158_RS10750 (LL158_03450)	-	2118893..2119117 (-)	225	WP_021211256.1	hypothetical protein	-
LL158_RS10755 (LL158_2072)	-	2119184..2120074 (+)	891	WP_015082946.1	IS982 family transposase	-
LL158_RS10760 (LL158_2073)	kwcM	2120181..2121500 (-)	1320	WP_015082947.1	KxxxW cyclic peptide radical SAM maturase	-
LL158_RS10765 (LL158_2074)	-	2121568..2121681 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
LL158_RS10770 (LL158_2075)	sepM	2122000..2123031 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator
LL158_RS10775 (LL158_2076)	coaD	2123015..2123515 (-)	501	WP_011677214.1	pantetheine-phosphate adenylyltransferase	-
LL158_RS10780 (LL158_2077)	rsmD	2123563..2124102 (-)	540	WP_031286167.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LL158_RS10785 (LL158_2078)	-	2124272..2125492 (-)	1221	WP_011677216.1	MFS transporter	-
LL158_RS10790 (LL158_2079)	lmrP	2125572..2126798 (-)	1227	Protein_2097	multidrug efflux MFS transporter LmrP	-
LL158_RS10795 (LL158_2080)	-	2126986..2127480 (+)	495	WP_015082948.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37398.03 Da
• Isoelectric Point: 9.8499

>NTDB_id=182858 LL158_RS10770 WP_011677213.1 2122000..2123031(-) (sepM) [Lactococcus cremoris strain 158]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=182858 LL158_RS10770 WP_011677213.1 2122000..2123031(-) (sepM) [Lactococcus cremoris strain 158]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A166ZHD8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.49