Detailed information NTG0181773

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A7327_RS10170
• Genome accession: NZ_CP015646
• Coordinates: 2052963..2054006 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 08-02300
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2047963..2059006

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7327_RS10140 (A7327_10135)	-	2048381..2049637 (-)	1257	WP_001789555.1	aminopeptidase	-
A7327_RS10145 (A7327_10140)	-	2049640..2049840 (-)	201	WP_000180460.1	DUF1128 family protein	-
A7327_RS10150 (A7327_10145)	-	2049987..2050451 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A7327_RS10155 (A7327_10150)	-	2050458..2050733 (+)	276	WP_000428171.1	hypothetical protein	-
A7327_RS10160 (A7327_10155)	-	2051011..2052228 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
A7327_RS10165 (A7327_10160)	vraR	2052344..2052973 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
A7327_RS10170 (A7327_10165)	vraS	2052963..2054006 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A7327_RS10175 (A7327_10170)	liaF	2054003..2054704 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A7327_RS10180 (A7327_10175)	-	2054719..2055105 (-)	387	WP_001110179.1	hypothetical protein	-
A7327_RS10185 (A7327_10180)	map	2055322..2056080 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
A7327_RS10190 (A7327_10185)	-	2056611..2057597 (+)	987	WP_000999716.1	FUSC family protein	-
A7327_RS10195 (A7327_10190)	-	2058087..2058500 (-)	414	WP_001670387.1	hypothetical protein	-
A7327_RS10200 (A7327_10195)	-	2058529..2058639 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=181773 A7327_RS10170 WP_001017131.1 2052963..2054006(-) (vraS) [Staphylococcus aureus strain 08-02300]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=181773 A7327_RS10170 WP_001017131.1 2052963..2054006(-) (vraS) [Staphylococcus aureus strain 08-02300]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1