Detailed information NTG0181699

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A7P66_RS00980
• Genome accession: NZ_CP015645
• Coordinates: 185722..186765 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 08-02119
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 180722..191765

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7P66_RS00945 (A7P66_00945)	-	181148..181258 (+)	111	WP_001790257.1	hypothetical protein	-
A7P66_RS00950 (A7P66_00950)	-	181287..181700 (+)	414	WP_001566709.1	hypothetical protein	-
A7P66_RS00955 (A7P66_00955)	-	182131..183117 (-)	987	WP_000999713.1	FUSC family protein	-
A7P66_RS00965 (A7P66_00965)	map	183648..184406 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
A7P66_RS00970 (A7P66_00970)	-	184623..185009 (+)	387	WP_001110179.1	hypothetical protein	-
A7P66_RS00975 (A7P66_00975)	liaF	185024..185725 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A7P66_RS00980 (A7P66_00980)	vraS	185722..186765 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A7P66_RS00985 (A7P66_00985)	vraR	186755..187384 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
A7P66_RS00990 (A7P66_00990)	-	187496..188713 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
A7P66_RS00995 (A7P66_00995)	-	188991..189266 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
A7P66_RS01000 (A7P66_01000)	-	189273..189737 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A7P66_RS01005 (A7P66_01005)	-	189884..190084 (+)	201	WP_000180460.1	DUF1128 family protein	-
A7P66_RS01010 (A7P66_01010)	-	190087..191343 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=181699 A7P66_RS00980 WP_001017131.1 185722..186765(+) (vraS) [Staphylococcus aureus strain 08-02119]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=181699 A7P66_RS00980 WP_001017131.1 185722..186765(+) (vraS) [Staphylococcus aureus strain 08-02119]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1