Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | Lh8105_RS10270 | Genome accession | NZ_CP015496 |
| Coordinates | 1960312..1962108 (+) | Length | 598 a.a. |
| NCBI ID | WP_101854021.1 | Uniprot ID | A0AAU8XW42 |
| Organism | Lactobacillus helveticus strain FAM8105 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1901867..1966862 | 1960312..1962108 | within | 0 |
| IScluster/Tn | 1930442..1963350 | 1960312..1962108 | within | 0 |
Gene organization within MGE regions
Location: 1901867..1966862
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Lh8105_RS09980 (Lh8105_09615) | - | 1903244..1904484 (+) | 1241 | Protein_1914 | IS110-like element ISLhe4 family transposase | - |
| Lh8105_RS09985 (Lh8105_09620) | - | 1904820..1906286 (-) | 1467 | WP_101853997.1 | flippase | - |
| Lh8105_RS09990 (Lh8105_09625) | - | 1906310..1907272 (-) | 963 | WP_101853998.1 | glycosyltransferase family 2 protein | - |
| Lh8105_RS09995 (Lh8105_09630) | - | 1907470..1908648 (+) | 1179 | WP_101853987.1 | IS256-like element IS1201 family transposase | - |
| Lh8105_RS10000 (Lh8105_09635) | - | 1909126..1910184 (+) | 1059 | WP_101853999.1 | IS30 family transposase | - |
| Lh8105_RS10005 (Lh8105_09640) | - | 1910197..1911174 (-) | 978 | WP_101854000.1 | glycosyltransferase family 2 protein | - |
| Lh8105_RS10010 (Lh8105_09645) | - | 1911328..1912506 (-) | 1179 | WP_101854001.1 | IS256-like element IS1201 family transposase | - |
| Lh8105_RS11945 | - | 1912590..1912730 (-) | 141 | WP_158648625.1 | hypothetical protein | - |
| Lh8105_RS10015 (Lh8105_09650) | - | 1912907..1913881 (-) | 975 | WP_101854002.1 | glycosyltransferase family 2 protein | - |
| Lh8105_RS10020 (Lh8105_09655) | - | 1913967..1915058 (-) | 1092 | WP_101854003.1 | EpsG family protein | - |
| Lh8105_RS10025 (Lh8105_09660) | - | 1915132..1915953 (-) | 822 | WP_101854004.1 | glycosyltransferase family 2 protein | - |
| Lh8105_RS10030 (Lh8105_09665) | - | 1915968..1916870 (-) | 903 | WP_101854005.1 | capsular polysaccharide synthesis protein | - |
| Lh8105_RS10035 (Lh8105_09670) | - | 1916870..1917682 (-) | 813 | WP_056970778.1 | glycosyltransferase family 2 protein | - |
| Lh8105_RS10040 (Lh8105_09675) | - | 1917673..1918797 (-) | 1125 | WP_101854006.1 | glycosyltransferase family 4 protein | - |
| Lh8105_RS10045 (Lh8105_09680) | - | 1918803..1919453 (-) | 651 | WP_181413856.1 | sugar transferase | - |
| Lh8105_RS10050 (Lh8105_09685) | - | 1919604..1921010 (-) | 1407 | WP_101853687.1 | ISLre2-like element ISLhe10 family transposase | - |
| Lh8105_RS10055 (Lh8105_09690) | - | 1921321..1922598 (+) | 1278 | WP_101854008.1 | ISL3 family transposase | - |
| Lh8105_RS10060 (Lh8105_09695) | - | 1922609..1923400 (-) | 792 | WP_101854009.1 | tyrosine-protein phosphatase | - |
| Lh8105_RS10065 (Lh8105_09700) | - | 1923400..1924188 (-) | 789 | WP_101854010.1 | CpsD/CapB family tyrosine-protein kinase | - |
| Lh8105_RS10070 (Lh8105_09705) | - | 1924199..1925086 (-) | 888 | WP_101854011.1 | YveK family protein | - |
| Lh8105_RS10075 (Lh8105_09710) | - | 1925098..1926159 (-) | 1062 | WP_101854012.1 | LCP family protein | - |
| Lh8105_RS10080 (Lh8105_09715) | hflX | 1926640..1927905 (+) | 1266 | WP_014919408.1 | GTPase HflX | - |
| Lh8105_RS10085 (Lh8105_09720) | - | 1927927..1928940 (+) | 1014 | WP_101854013.1 | CAP domain-containing protein | - |
| Lh8105_RS10090 (Lh8105_09725) | - | 1929151..1930083 (-) | 933 | WP_101854014.1 | C40 family peptidase | - |
| Lh8105_RS10095 (Lh8105_09735) | - | 1930231..1930909 (-) | 679 | Protein_1938 | UPF0236 family transposase-like protein | - |
| Lh8105_RS10100 (Lh8105_09740) | - | 1931111..1931887 (-) | 777 | WP_014919428.1 | C40 family peptidase | - |
| Lh8105_RS10105 (Lh8105_09745) | - | 1932105..1932458 (-) | 354 | WP_023192440.1 | ATPase | - |
| Lh8105_RS10110 (Lh8105_09750) | - | 1932804..1934366 (-) | 1563 | WP_023192439.1 | RNA-guided endonuclease TnpB family protein | - |
| Lh8105_RS10115 (Lh8105_09755) | - | 1934320..1934970 (-) | 651 | WP_014919431.1 | IS607-like element ISLhe9 family transposase | - |
| Lh8105_RS10120 (Lh8105_09760) | - | 1935036..1935356 (-) | 321 | WP_023062121.1 | AAA family ATPase | - |
| Lh8105_RS10125 (Lh8105_09765) | - | 1935404..1935613 (-) | 210 | WP_023192438.1 | Protein of unknown function | - |
| Lh8105_RS10130 (Lh8105_09770) | - | 1935708..1936961 (-) | 1254 | WP_101854088.1 | RNA-guided endonuclease TnpB family protein | - |
| Lh8105_RS10135 (Lh8105_09775) | - | 1937020..1937289 (-) | 270 | WP_003627295.1 | hypothetical protein | - |
| Lh8105_RS10140 (Lh8105_09780) | - | 1937383..1937934 (-) | 552 | WP_003627296.1 | C40 family peptidase | - |
| Lh8105_RS10145 (Lh8105_09785) | - | 1938124..1938669 (-) | 546 | WP_020828975.1 | guanylate kinase | - |
| Lh8105_RS10150 (Lh8105_09790) | - | 1938764..1939063 (+) | 300 | WP_101854015.1 | DUF2187 domain-containing protein | - |
| Lh8105_RS10155 (Lh8105_09795) | - | 1939156..1940661 (+) | 1506 | WP_101854016.1 | O-antigen ligase family protein | - |
| Lh8105_RS10160 (Lh8105_09800) | - | 1940676..1941317 (-) | 642 | WP_072748773.1 | LVIS_2131 family protein | - |
| Lh8105_RS10165 (Lh8105_09805) | - | 1941562..1942755 (-) | 1194 | WP_101854017.1 | RNA-guided endonuclease TnpB family protein | - |
| Lh8105_RS10170 (Lh8105_09810) | - | 1942839..1944017 (+) | 1179 | WP_012211358.1 | IS256 family transposase | - |
| Lh8105_RS10180 (Lh8105_09815) | - | 1944389..1945567 (-) | 1179 | WP_101853987.1 | IS256-like element IS1201 family transposase | - |
| Lh8105_RS10185 (Lh8105_09820) | - | 1945824..1946168 (-) | 345 | WP_101854018.1 | hypothetical protein | - |
| Lh8105_RS10190 (Lh8105_09825) | - | 1946281..1946817 (-) | 537 | WP_003627306.1 | hypothetical protein | - |
| Lh8105_RS10195 (Lh8105_09830) | - | 1946993..1948222 (-) | 1230 | WP_101854019.1 | RNA-guided endonuclease TnpB family protein | - |
| Lh8105_RS10205 (Lh8105_09835) | - | 1948473..1949750 (+) | 1278 | WP_101853673.1 | ISL3 family transposase | - |
| Lh8105_RS10210 (Lh8105_09840) | - | 1949998..1950483 (-) | 486 | WP_012212260.1 | threonine/serine exporter family protein | - |
| Lh8105_RS10215 (Lh8105_09845) | - | 1950486..1951256 (-) | 771 | WP_012212261.1 | threonine/serine exporter family protein | - |
| Lh8105_RS10220 (Lh8105_09850) | - | 1951267..1952808 (-) | 1542 | WP_012212262.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| Lh8105_RS10225 (Lh8105_09855) | - | 1952817..1953194 (-) | 378 | WP_023190894.1 | hypothetical protein | - |
| Lh8105_RS10230 (Lh8105_09860) | - | 1953386..1953883 (+) | 498 | WP_229020345.1 | GNAT family N-acetyltransferase | - |
| Lh8105_RS10235 (Lh8105_09865) | - | 1953880..1954385 (-) | 506 | Protein_1964 | DUF554 family protein | - |
| Lh8105_RS10240 (Lh8105_09870) | - | 1954481..1955699 (-) | 1219 | Protein_1965 | RNA-guided endonuclease TnpB family protein | - |
| Lh8105_RS10250 (Lh8105_09875) | - | 1955792..1955980 (-) | 189 | Protein_1966 | DUF554 family protein | - |
| Lh8105_RS10255 (Lh8105_09880) | - | 1956191..1957468 (+) | 1278 | WP_101853673.1 | ISL3 family transposase | - |
| Lh8105_RS10260 (Lh8105_09885) | - | 1957519..1958760 (-) | 1242 | WP_101854020.1 | LCP family protein | - |
| Lh8105_RS10265 (Lh8105_09890) | - | 1958892..1960070 (-) | 1179 | WP_012211358.1 | IS256 family transposase | - |
| Lh8105_RS10270 (Lh8105_09895) | pepF | 1960312..1962108 (+) | 1797 | WP_101854021.1 | oligoendopeptidase F | Regulator |
| Lh8105_RS10275 (Lh8105_09900) | - | 1962432..1962689 (+) | 258 | WP_012212265.1 | Fic family protein | - |
| Lh8105_RS10285 (Lh8105_09910) | - | 1962976..1963350 (+) | 375 | Protein_1972 | transposase | - |
| Lh8105_RS10290 (Lh8105_09915) | - | 1963607..1964983 (-) | 1377 | WP_023190802.1 | L-cystine transporter | - |
| Lh8105_RS10295 (Lh8105_09920) | - | 1965421..1966215 (-) | 795 | WP_003627328.1 | metal ABC transporter permease | - |
| Lh8105_RS10300 (Lh8105_09925) | - | 1966215..1966862 (-) | 648 | WP_012212267.1 | metal ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 598 a.a. Molecular weight: 68144.23 Da Isoelectric Point: 4.9296
>NTDB_id=180094 Lh8105_RS10270 WP_101854021.1 1960312..1962108(+) (pepF) [Lactobacillus helveticus strain FAM8105]
MAIPTRSEVPEDLKWDLTRIFKTDQDWENAFDKAKDDVAKLSELKGSLAKSGKDLYEGLTKILAVKRDVENIYVYATMSS
DVDTSNSHYLGYVSRMQSLSNQFEAATSFINPEILSIPAEKFEQFKKDEPRLADYAHYLEMITNKRPHTLPAEEEKIIAD
AGDAMSVSENTFNVLTNSDMEYGYVQDEDGNMEQLSNGLYSLLIQSQNRDVRKGAFNTLYASYGQFQNSLASTLSGVVKK
HNYNARMHKYDSAREAALADNGVPVEVYDTLIKEVDSHLDLLHRYVALRKKILGLKDLQMWDMYVPLTGKPALSYNFEEA
KKVAKEAMKPLGEDYLKHVDYIFNNRVIDPVESKGKVTGAYSGGAYDTDPYELLNWEDNIDSLYTLVHETGHSVHSWYTR
HSQPYIYGNYPIFVAEIASTTNENILTEYFLDHITDPKTRAFILNHYLDSFKGTLFRQTQFAVFEQFIHEADTKGEPLTA
DILNDVYGQINQHYYGDSVEPGGDIALEWSRIPHFYYNFYVYQYATGFAAATALANKVVHGSQADRDAYLGYLKSGSSDY
PTEIMKRAGVDMTKPDYLKDAFKTFEKRLNEFESLIGK
MAIPTRSEVPEDLKWDLTRIFKTDQDWENAFDKAKDDVAKLSELKGSLAKSGKDLYEGLTKILAVKRDVENIYVYATMSS
DVDTSNSHYLGYVSRMQSLSNQFEAATSFINPEILSIPAEKFEQFKKDEPRLADYAHYLEMITNKRPHTLPAEEEKIIAD
AGDAMSVSENTFNVLTNSDMEYGYVQDEDGNMEQLSNGLYSLLIQSQNRDVRKGAFNTLYASYGQFQNSLASTLSGVVKK
HNYNARMHKYDSAREAALADNGVPVEVYDTLIKEVDSHLDLLHRYVALRKKILGLKDLQMWDMYVPLTGKPALSYNFEEA
KKVAKEAMKPLGEDYLKHVDYIFNNRVIDPVESKGKVTGAYSGGAYDTDPYELLNWEDNIDSLYTLVHETGHSVHSWYTR
HSQPYIYGNYPIFVAEIASTTNENILTEYFLDHITDPKTRAFILNHYLDSFKGTLFRQTQFAVFEQFIHEADTKGEPLTA
DILNDVYGQINQHYYGDSVEPGGDIALEWSRIPHFYYNFYVYQYATGFAAATALANKVVHGSQADRDAYLGYLKSGSSDY
PTEIMKRAGVDMTKPDYLKDAFKTFEKRLNEFESLIGK
Nucleotide
Download Length: 1797 bp
>NTDB_id=180094 Lh8105_RS10270 WP_101854021.1 1960312..1962108(+) (pepF) [Lactobacillus helveticus strain FAM8105]
ATGGCGATTCCAACAAGAAGCGAAGTCCCAGAAGATTTGAAGTGGGATTTAACCCGCATCTTTAAAACAGACCAAGACTG
GGAAAATGCCTTTGACAAGGCAAAAGATGACGTGGCTAAGCTAAGTGAATTAAAGGGAAGCTTGGCTAAATCAGGCAAAG
ATTTGTATGAAGGCTTGACCAAGATTTTGGCAGTTAAACGTGATGTAGAAAATATTTACGTTTATGCCACTATGTCTAGC
GATGTTGATACTTCTAACTCACATTATTTGGGCTACGTTAGCCGCATGCAAAGCTTGTCCAATCAATTTGAAGCAGCAAC
CAGTTTTATTAATCCTGAAATTTTGAGTATCCCTGCCGAAAAGTTTGAACAATTCAAAAAAGACGAGCCAAGATTAGCTG
ATTACGCCCACTATTTGGAAATGATCACTAACAAGCGTCCTCATACTTTGCCAGCAGAAGAAGAAAAAATTATCGCTGAC
GCAGGGGATGCCATGAGCGTGTCAGAGAATACCTTTAACGTTTTAACCAACTCTGACATGGAATATGGTTATGTGCAAGA
TGAAGACGGCAACATGGAGCAATTATCCAATGGCTTGTATTCATTATTGATTCAGTCCCAAAATCGTGACGTGCGTAAAG
GTGCTTTTAATACTCTCTATGCCAGCTATGGTCAATTCCAAAACTCGCTTGCCTCTACTCTCTCCGGCGTTGTGAAAAAA
CATAACTACAACGCACGCATGCACAAGTATGATTCAGCTCGTGAAGCCGCATTAGCTGATAACGGCGTACCTGTTGAAGT
TTACGACACATTAATTAAAGAAGTTGATTCACACCTTGACTTGCTTCACCGTTATGTCGCATTGCGCAAGAAAATTTTAG
GTCTTAAAGACTTACAAATGTGGGACATGTACGTGCCGCTAACTGGTAAGCCTGCTTTGTCTTACAACTTTGAAGAGGCT
AAAAAGGTAGCTAAAGAAGCCATGAAGCCACTTGGCGAAGACTACTTAAAGCATGTTGATTATATTTTTAACAACCGTGT
GATTGATCCTGTTGAATCTAAGGGCAAGGTTACTGGTGCTTACTCTGGTGGTGCTTACGATACCGATCCATATGAACTTT
TGAACTGGGAAGACAATATCGATTCACTCTATACTTTAGTTCATGAAACTGGACACTCAGTTCACTCTTGGTACACCCGC
CACAGTCAGCCTTATATCTATGGTAATTACCCAATCTTCGTGGCTGAAATTGCTTCAACCACTAATGAAAATATTTTGAC
TGAATATTTCTTGGACCATATTACTGATCCTAAGACGCGCGCATTCATCTTGAACCACTACCTTGATTCATTCAAGGGTA
CATTGTTCCGCCAAACTCAATTTGCGGTATTTGAACAATTTATCCACGAAGCAGATACTAAGGGCGAACCATTGACTGCC
GATATTTTGAATGATGTTTATGGTCAAATTAACCAGCATTACTACGGCGACAGTGTTGAACCTGGTGGCGATATTGCGCT
TGAATGGTCACGAATTCCGCACTTCTACTACAACTTCTACGTTTATCAATATGCGACTGGATTTGCGGCTGCAACGGCTT
TGGCTAACAAGGTTGTGCATGGTAGTCAGGCTGATAGGGATGCATACCTGGGCTACCTTAAGTCAGGTTCTAGTGACTAT
CCTACTGAGATCATGAAGCGTGCCGGCGTTGACATGACTAAGCCCGATTATTTGAAAGATGCTTTCAAGACTTTTGAAAA
GAGATTGAACGAATTCGAGAGTTTGATTGGTAAGTAA
ATGGCGATTCCAACAAGAAGCGAAGTCCCAGAAGATTTGAAGTGGGATTTAACCCGCATCTTTAAAACAGACCAAGACTG
GGAAAATGCCTTTGACAAGGCAAAAGATGACGTGGCTAAGCTAAGTGAATTAAAGGGAAGCTTGGCTAAATCAGGCAAAG
ATTTGTATGAAGGCTTGACCAAGATTTTGGCAGTTAAACGTGATGTAGAAAATATTTACGTTTATGCCACTATGTCTAGC
GATGTTGATACTTCTAACTCACATTATTTGGGCTACGTTAGCCGCATGCAAAGCTTGTCCAATCAATTTGAAGCAGCAAC
CAGTTTTATTAATCCTGAAATTTTGAGTATCCCTGCCGAAAAGTTTGAACAATTCAAAAAAGACGAGCCAAGATTAGCTG
ATTACGCCCACTATTTGGAAATGATCACTAACAAGCGTCCTCATACTTTGCCAGCAGAAGAAGAAAAAATTATCGCTGAC
GCAGGGGATGCCATGAGCGTGTCAGAGAATACCTTTAACGTTTTAACCAACTCTGACATGGAATATGGTTATGTGCAAGA
TGAAGACGGCAACATGGAGCAATTATCCAATGGCTTGTATTCATTATTGATTCAGTCCCAAAATCGTGACGTGCGTAAAG
GTGCTTTTAATACTCTCTATGCCAGCTATGGTCAATTCCAAAACTCGCTTGCCTCTACTCTCTCCGGCGTTGTGAAAAAA
CATAACTACAACGCACGCATGCACAAGTATGATTCAGCTCGTGAAGCCGCATTAGCTGATAACGGCGTACCTGTTGAAGT
TTACGACACATTAATTAAAGAAGTTGATTCACACCTTGACTTGCTTCACCGTTATGTCGCATTGCGCAAGAAAATTTTAG
GTCTTAAAGACTTACAAATGTGGGACATGTACGTGCCGCTAACTGGTAAGCCTGCTTTGTCTTACAACTTTGAAGAGGCT
AAAAAGGTAGCTAAAGAAGCCATGAAGCCACTTGGCGAAGACTACTTAAAGCATGTTGATTATATTTTTAACAACCGTGT
GATTGATCCTGTTGAATCTAAGGGCAAGGTTACTGGTGCTTACTCTGGTGGTGCTTACGATACCGATCCATATGAACTTT
TGAACTGGGAAGACAATATCGATTCACTCTATACTTTAGTTCATGAAACTGGACACTCAGTTCACTCTTGGTACACCCGC
CACAGTCAGCCTTATATCTATGGTAATTACCCAATCTTCGTGGCTGAAATTGCTTCAACCACTAATGAAAATATTTTGAC
TGAATATTTCTTGGACCATATTACTGATCCTAAGACGCGCGCATTCATCTTGAACCACTACCTTGATTCATTCAAGGGTA
CATTGTTCCGCCAAACTCAATTTGCGGTATTTGAACAATTTATCCACGAAGCAGATACTAAGGGCGAACCATTGACTGCC
GATATTTTGAATGATGTTTATGGTCAAATTAACCAGCATTACTACGGCGACAGTGTTGAACCTGGTGGCGATATTGCGCT
TGAATGGTCACGAATTCCGCACTTCTACTACAACTTCTACGTTTATCAATATGCGACTGGATTTGCGGCTGCAACGGCTT
TGGCTAACAAGGTTGTGCATGGTAGTCAGGCTGATAGGGATGCATACCTGGGCTACCTTAAGTCAGGTTCTAGTGACTAT
CCTACTGAGATCATGAAGCGTGCCGGCGTTGACATGACTAAGCCCGATTATTTGAAAGATGCTTTCAAGACTTTTGAAAA
GAGATTGAACGAATTCGAGAGTTTGATTGGTAAGTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
51.347 |
99.331 |
0.51 |