Detailed information NTG0179940

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A6V38_RS10655
• Genome accession: NZ_CP015447
• Coordinates: 2047573..2048616 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain M92
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2042573..2053616

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6V38_RS10625 (A6V38_10610)	-	2042991..2044247 (-)	1257	WP_001795438.1	aminopeptidase	-
A6V38_RS10630 (A6V38_10615)	-	2044250..2044450 (-)	201	WP_000180461.1	DUF1128 family protein	-
A6V38_RS10635 (A6V38_10620)	-	2044597..2045061 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A6V38_RS10640 (A6V38_10625)	-	2045068..2045343 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
A6V38_RS10645 (A6V38_10630)	-	2045621..2046838 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
A6V38_RS10650 (A6V38_10635)	vraR	2046954..2047583 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
A6V38_RS10655 (A6V38_10640)	vraS	2047573..2048616 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A6V38_RS10660 (A6V38_10645)	liaF	2048613..2049314 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A6V38_RS10665 (A6V38_10650)	-	2049329..2049715 (-)	387	WP_001110179.1	hypothetical protein	-
A6V38_RS10670 (A6V38_10655)	map	2049932..2050690 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
A6V38_RS10680 (A6V38_10665)	-	2051277..2052263 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
A6V38_RS10690 (A6V38_10675)	-	2052694..2053107 (-)	414	WP_001549145.1	hypothetical protein	-
A6V38_RS10695 (A6V38_10680)	-	2053136..2053246 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=179940 A6V38_RS10655 WP_001017131.1 2047573..2048616(-) (vraS) [Staphylococcus aureus strain M92]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=179940 A6V38_RS10655 WP_001017131.1 2047573..2048616(-) (vraS) [Staphylococcus aureus strain M92]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1