Detailed information NTG0178877

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: AS891_RS01465
• Genome accession: NZ_CP015375
• Coordinates: 290500..292932 (-)
• Length: 810 a.a.
• NCBI ID: WP_003235011.1
• Uniprot ID: P37571
• Organism: Bacillus subtilis subsp. subtilis strain KCTC 3135
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 285500..297932

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AS891_RS01440 (AS891_01440)	ispF	285548..286024 (-)	477	WP_003225745.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
AS891_RS01445 (AS891_01445)	ispD	286017..286715 (-)	699	WP_003235019.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
AS891_RS01450 (AS891_01450)	yacL	286730..287830 (-)	1101	WP_003235014.1	PIN/TRAM domain-containing protein	-
AS891_RS01455 (AS891_01455)	disA	287946..289028 (-)	1083	WP_003225736.1	DNA integrity scanning diadenylate cyclase DisA	-
AS891_RS01460 (AS891_01460)	radA	289032..290408 (-)	1377	WP_004399687.1	DNA repair protein RadA	Machinery gene
AS891_RS01465 (AS891_01465)	clpC	290500..292932 (-)	2433	WP_003235011.1	ATP-dependent protease ATP-binding subunit ClpC	Regulator
AS891_RS01470 (AS891_01470)	mcsB	292929..294020 (-)	1092	WP_003235007.1	protein arginine kinase	-
AS891_RS01475 (AS891_01475)	mcsA	294020..294577 (-)	558	WP_009966297.1	protein-arginine kinase activator protein McsA	-
AS891_RS01480 (AS891_01480)	ctsR	294591..295055 (-)	465	WP_003225724.1	transcriptional regulator CtsR	-

Sequence

Protein

• Length: 810 a.a.
• Molecular weight: 90118.60 Da
• Isoelectric Point: 6.0257

>NTDB_id=178877 AS891_RS01465 WP_003235011.1 290500..292932(-) (clpC) [Bacillus subtilis subsp. subtilis strain KCTC 3135]
MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEGIAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT
PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRVM
TLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEY
RKYIEKDAALERRFQPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAIDLIDEAGS
KVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQENSEVTVDDIAMVV
SSWTGVPVSKIAQTETDKLLNMENILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAE
SIFGDEESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRLT
DSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLT
EIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVEDGE
FVVKTTAKTN

Nucleotide

• Length: 2433 bp

>NTDB_id=178877 AS891_RS01465 WP_003235011.1 290500..292932(-) (clpC) [Bacillus subtilis subsp. subtilis strain KCTC 3135]
ATGATGTTTGGAAGATTTACAGAACGAGCTCAAAAAGTACTGGCGCTAGCACAGGAAGAAGCACTTCGGTTAGGTCATAA
TAACATTGGCACTGAGCATATTTTATTAGGACTGGTAAGAGAAGGAGAGGGCATTGCTGCTAAAGCTCTTCAAGCGCTTG
GACTCGGTTCAGAAAAAATTCAGAAAGAAGTAGAAAGTTTGATCGGGCGCGGGCAGGAAATGTCTCAAACGATTCATTAT
ACTCCTAGAGCTAAAAAAGTCATTGAGCTTTCAATGGATGAGGCAAGAAAACTCGGTCATTCTTATGTGGGAACAGAACA
TATTCTTCTTGGTCTGATTCGTGAAGGAGAAGGTGTTGCTGCGAGAGTTCTGAATAATCTCGGTGTCAGCTTAAATAAAG
CAAGACAGCAGGTGCTCCAGCTTCTAGGAAGTAATGAAACAGGATCATCAGCGGCAGGAACAAACAGCAATGCGAATACG
CCTACGCTTGACAGCTTGGCAAGAGACTTAACTGCTATTGCGAAGGAAGACAGCCTTGACCCTGTAATCGGCAGAAGCAA
GGAGATCCAGCGTGTCATTGAAGTGTTAAGCCGCAGAACGAAAAACAACCCTGTTCTCATTGGGGAACCAGGTGTAGGTA
AAACGGCTATCGCAGAAGGTTTGGCACAGCAAATTATCAATAATGAAGTACCCGAAATTTTGCGTGATAAACGTGTGATG
ACATTAGACATGGGAACAGTTGTTGCCGGCACAAAATACCGCGGAGAATTTGAGGATCGCCTGAAGAAGGTCATGGATGA
AATTCGCCAGGCAGGAAATATCATTCTATTCATCGATGAGCTCCATACATTAATCGGGGCAGGCGGAGCAGAAGGTGCTA
TTGATGCATCTAATATTTTAAAACCTTCACTTGCTCGTGGCGAACTCCAATGTATTGGTGCAACGACTCTTGATGAGTAC
CGTAAATATATTGAAAAAGATGCAGCACTGGAACGCCGTTTTCAGCCGATTCAGGTTGATCAGCCATCTGTAGATGAAAG
TATTCAAATTTTACAAGGTCTGCGTGACAGATACGAAGCCCACCACCGCGTTTCTATCACTGATGATGCCATTGAAGCTG
CGGTTAAGCTTTCTGACAGATATATTTCTGACCGCTTCCTTCCGGATAAAGCAATTGACTTGATCGATGAAGCGGGTTCA
AAGGTGAGACTGCGCTCATTTACAACGCCTCCTAACTTAAAAGAGCTTGAGCAGAAGCTTGATGAGGTTCGTAAAGAGAA
GGATGCGGCAGTGCAAAGCCAAGAGTTTGAAAAAGCTGCTTCCTTGCGTGATACTGAACAACGCCTGCGCGAGCAAGTAG
AGGATACGAAGAAATCATGGAAAGAGAAGCAAGGGCAGGAAAACTCAGAGGTTACTGTGGATGATATTGCGATGGTTGTA
TCCAGCTGGACCGGTGTGCCTGTATCTAAAATCGCCCAAACTGAAACTGATAAGCTTCTCAATATGGAAAACATTCTTCA
CTCCCGTGTCATCGGCCAGGATGAAGCAGTTGTAGCGGTTGCAAAAGCCGTCAGACGTGCAAGAGCAGGATTGAAAGATC
CTAAACGCCCAATCGGCTCATTCATTTTCTTAGGCCCTACAGGTGTAGGTAAAACAGAACTTGCACGAGCACTTGCTGAA
TCCATTTTTGGCGATGAAGAATCCATGATCAGAATTGATATGTCTGAATACATGGAAAAACATTCAACTTCAAGACTTGT
TGGTTCACCTCCGGGTTATGTGGGATATGATGAAGGCGGTCAATTGACAGAGAAAGTCAGAAGAAAACCTTACTCTGTCG
TGCTTCTTGATGAGATCGAGAAAGCGCACCCTGATGTCTTCAATATCCTTCTGCAAGTTCTTGAAGACGGACGATTGACT
GATTCTAAAGGACGCACAGTCGATTTCCGCAATACCATTCTGATCATGACATCAAACGTCGGAGCAAGTGAGCTAAAACG
CAATAAATATGTCGGCTTTAACGTTCAGGATGAAACTCAAAATCATAAAGACATGAAAGATAAAGTGATGGGTGAATTAA
AACGAGCGTTCAGACCTGAGTTCATCAACCGTATTGATGAAATCATTGTCTTCCATTCACTTGAGAAAAAACATCTCACT
GAGATTGTGTCATTAATGTCTGATCAATTAACGAAACGCCTGAAAGAACAAGATCTTTCTATCGAATTGACAGATGCTGC
AAAAGCGAAAGTCGCGGAAGAGGGCGTTGACCTGGAATACGGTGCCCGTCCGTTAAGAAGAGCGATCCAAAAACATGTCG
AGGATCGTTTATCTGAAGAACTCCTCAGAGGAAATATTCATAAAGGACAGCATATTGTTCTTGATGTAGAAGATGGCGAA
TTTGTCGTAAAAACGACTGCTAAAACGAATTAA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-143)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-69)

• AAA lid domain (AAA_lid_9) (343-444)

• ATPase family associated with various cellular activities (AAA) (AAA) (205-317)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (714-793)

• AAA domain (Cdc48 subfamily) (AAA_2) (536-708)

3D structure

• PDB: 2K77
• PDB: 2Y1Q
• PDB: 2Y1R
• PDB: 3J3R
• PDB: 3J3S
• PDB: 3J3T
• PDB: 3J3U
• PDB: 3PXG
• PDB: 3PXI
• PDB: 5HBN
• PDB: 7ABR
• PDB: 8B3S
• PDB: 8OTK

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	100	100	1
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.499	99.012	0.5
clpC	Streptococcus thermophilus LMD-9	46.65	100	0.473
clpC	Streptococcus thermophilus LMG 18311	46.407	100	0.47
clpC	Streptococcus pneumoniae Rx1	45.241	99.877	0.452
clpC	Streptococcus pneumoniae D39	45.241	99.877	0.452
clpC	Streptococcus pneumoniae TIGR4	45.117	99.877	0.451
clpC	Streptococcus mutans UA159	43.584	100	0.444
clpE	Streptococcus mutans UA159	53.313	80.123	0.427
clpC	Lactococcus lactis subsp. cremoris KW2	48.664	87.778	0.427
clpE	Streptococcus pneumoniae TIGR4	52.388	80.123	0.42
clpE	Streptococcus pneumoniae Rx1	52.388	80.123	0.42
clpE	Streptococcus pneumoniae D39	52.388	80.123	0.42
clpE	Streptococcus pneumoniae R6	52.388	80.123	0.42