Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   NX99_RS03975 Genome accession   NZ_CP015282
Coordinates   944597..946867 (+) Length   756 a.a.
NCBI ID   WP_073687523.1    Uniprot ID   A0AB37D945
Organism   Streptococcus salivarius strain ATCC 27945     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 939597..951867
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NX99_RS03950 (NX99_03885) - 940699..941175 (-) 477 WP_037599232.1 ferrous iron transport protein A -
  NX99_RS03955 (NX99_03890) - 941347..942081 (-) 735 WP_002886191.1 amino acid ABC transporter ATP-binding protein -
  NX99_RS03960 (NX99_03895) - 942081..942761 (-) 681 WP_002886081.1 amino acid ABC transporter permease -
  NX99_RS03965 (NX99_03900) - 943075..943305 (-) 231 WP_002885970.1 DUF1797 family protein -
  NX99_RS03970 (NX99_03905) argF 943374..944354 (-) 981 WP_084914832.1 ornithine carbamoyltransferase -
  NX99_RS03975 (NX99_03910) clpE 944597..946867 (+) 2271 WP_073687523.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  NX99_RS03980 (NX99_03915) - 947010..947468 (+) 459 WP_084914834.1 NUDIX hydrolase -
  NX99_RS03985 (NX99_03920) - 947478..947780 (+) 303 WP_002885967.1 DUF1827 family protein -
  NX99_RS03990 (NX99_03925) - 947826..948788 (-) 963 WP_084914835.1 Gfo/Idh/MocA family protein -
  NX99_RS03995 (NX99_03930) - 948886..950121 (-) 1236 WP_084914837.1 aminoacyltransferase -
  NX99_RS04000 (NX99_03935) - 950099..950782 (-) 684 WP_014633415.1 TVP38/TMEM64 family protein -
  NX99_RS04005 (NX99_03940) - 950865..951485 (-) 621 WP_002885892.1 DUF3862 domain-containing protein -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 83973.05 Da        Isoelectric Point: 5.0564

>NTDB_id=178206 NX99_RS03975 WP_073687523.1 944597..946867(+) (clpE) [Streptococcus salivarius strain ATCC 27945]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQNCYKIMKSDPENPLNQFNQTGGSNFFDDFFSDLNNFRSSNGDLPNTPPTQ
EGGNRGNGGNTQGPGRPGGPRQQAPQQPQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPG
VGKTAVVEGLAQKIVDGSVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNAG
DGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAI
TAAAELSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKDIDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQ
KQTIKDQDMPVITEKHIEAIVEQKTNIPVGDLKEKEQSQLLSLADDLKSHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIG
SFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEV
EKAHPDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGATRENRTNSVLNQLGDFFSPEFMNRFD
GIIEFSALSKENLLTIVDLMLDNVNQRLANNGIHLSVTEKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLENPN
EKDLKAVMTSKGHITIKSAKKAEKATQKAEAAKESD

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=178206 NX99_RS03975 WP_073687523.1 944597..946867(+) (clpE) [Streptococcus salivarius strain ATCC 27945]
ATGCTCTGTCAAAACTGTAACCTTAATGAAGCTAGTATTCATTTGTATACCAATGTGAATGGTAATCAGCAACAAGTTGA
CCTCTGTCAAAATTGTTATAAAATCATGAAATCTGACCCAGAGAACCCCCTCAATCAATTCAATCAAACAGGAGGTTCAA
ACTTCTTCGATGATTTCTTCAGCGACCTAAATAACTTCCGTTCTTCTAACGGCGATCTTCCCAATACACCTCCAACACAA
GAAGGTGGTAACCGAGGAAACGGTGGCAATACACAAGGGCCAGGCCGTCCAGGAGGACCACGCCAACAAGCTCCTCAACA
GCCACAAGGTCTTCTTGAAGAGTTCGGCATTAACATCACTGACATCGCTCGTCGTGGAGACATTGATCCTGTTATTGGTC
GTGACGAGGAAATCATTCGTGTCATCGAAATTCTTAACCGCCGTACCAAGAACAACCCCGTCCTCATCGGTGAACCCGGT
GTCGGTAAGACTGCTGTTGTTGAAGGCCTAGCTCAAAAAATCGTTGACGGTAGCGTGCCACAAAAACTCCAAGGCAAACA
AGTCATCCGTCTTGATGTGGTCAGCCTGGTTCAAGGAACTGGTATCCGTGGCCAATTTGAAGAACGCATGCAAAAACTCA
TGGAAGAAATTCGTCAACGTCAGGATGTTATCCTATTTATTGATGAAATCCATGAAATTGTGGGAGCTGGTAATGCTGGT
GATGGCAATATGGATGCTGGAAACATCCTAAAACCTGCTCTTGCTCGTGGAGAACTTCAACTGGTCGGAGCAACAACACT
CAACGAATACCGCATCATCGAAAAAGATGCCGCCCTAGAGCGTCGTATGCAACCAGTTAAGGTTGACGAACCAACGGTTG
AGGAAACCATCACTATTTTGCGTGGTATTCAACCTAAATATCAGGACTACCACCACGTCAAATATACAGACGAAGCGATT
ACTGCAGCTGCAGAATTGTCCAACCGCTACATTCAAGACCGCTTCTTGCCAGACAAGGCCATCGACCTCCTCGATGAAGC
TGGTTCGAAGATGAATTTGACCCTCAATTTTGTTGATCCTAAAGATATCGACAAACGTTTGATTGAGGCTGAAAACCTCA
AGGCTCAAGCTACTCGTGACGAAGACTTTGAAAAAGCTGCCTATTTCCGTGATCAAATTGCCAAATACAAGGAAATGCAA
AAACAAACCATCAAAGACCAAGATATGCCTGTCATCACAGAAAAACATATCGAAGCCATTGTGGAACAAAAAACCAATAT
TCCTGTCGGTGATTTGAAAGAAAAAGAACAATCACAACTTCTTAGTCTTGCTGATGATCTTAAATCACATGTTATTGGAC
AAGATGCCGCAGTTGATAAGATTGCCAAAGCCATCCGCCGTAATCGTGTTGGATTGGGTGCACCAAATCGCCCAATTGGT
AGCTTCCTCTTCGTAGGTCCTACAGGAGTCGGTAAAACTGAACTCTCTAAACAATTGGCGATTGAACTCTTTGGTTCAGC
TGACAGTATGATTCGTTTCGATATGTCAGAATACATGGAAAAACACGCCGTCGCTAAATTGGTTGGTGCCCCTCCAGGAT
ATGTTGGTTACGACGAAGCTGGTCAGTTAACTGAAAAAGTCCGCCGTAATCCTTATTCACTTATTCTTTTAGATGAGGTT
GAAAAAGCTCACCCAGACGTTCTTCACATGTTCCTCCAAGTACTTGACGACGGTCGTTTGACTGATGGACAAGGGCGCAC
TGTAAGCTTCAAGGATACCATCATCATCATGACATCAAATGCTGGTACTGGTAAAGTTGAAGCTAGCGTTGGCTTTGGAG
CTACTCGTGAAAATCGTACCAATTCTGTTCTTAACCAACTTGGAGATTTCTTCAGTCCTGAATTCATGAACCGCTTTGAT
GGTATTATCGAATTCTCTGCCCTCAGCAAAGAAAATCTCCTTACTATCGTGGACCTCATGCTTGATAATGTCAACCAACG
CTTGGCTAACAACGGTATCCACCTCAGTGTAACTGAGAAAGTTAAGGAAAAATTGGTTGACCTTGGTTACGATCCTAAGA
TGGGTGCTCGACCACTACGTCGTACCATCCAAGATCACATTGAAGATGCTATTACCGACTTCTACCTTGAAAATCCAAAC
GAAAAAGATCTCAAGGCAGTCATGACTTCAAAAGGCCACATTACCATTAAGTCTGCTAAAAAAGCCGAAAAAGCTACTCA
AAAAGCTGAGGCAGCAAAAGAATCTGATTAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(154-274)

AAA domain (Cdc48 subfamily) (AAA_2)

(477-640)

AAA lid domain (AAA_lid_9)

(292-390)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(648-721)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

85.771

99.471

0.853
  clpE Streptococcus pneumoniae Rx1

83.134

99.603

0.828
  clpE Streptococcus pneumoniae D39

83.134

99.603

0.828
  clpE Streptococcus pneumoniae R6

83.134

99.603

0.828
  clpE Streptococcus pneumoniae TIGR4

83.134

99.603

0.828
  clpC Lactococcus lactis subsp. cremoris KW2

78.718

96.958

0.763
  clpC Bacillus subtilis subsp. subtilis str. 168

51.852

85.714

0.444
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.037

86.772

0.399
  clpC Streptococcus pneumoniae Rx1

47.36

82.672

0.392
  clpC Streptococcus pneumoniae D39

47.36

82.672

0.392
  clpC Streptococcus pneumoniae TIGR4

47.2

82.672

0.39
  clpC Streptococcus thermophilus LMD-9

47.04

82.672

0.389
  clpC Streptococcus thermophilus LMG 18311

46.72

82.672

0.386
  clpC Streptococcus mutans UA159

46.228

82.407

0.381

Multiple sequence alignment