Detailed information NTG0177920

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: A4265_RS08170
• Genome accession: NZ_CP015238
• Coordinates: 1633266..1635710 (-)
• Length: 814 a.a.
• NCBI ID: WP_063632169.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NS53
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1628266..1640710

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A4265_RS08145 (A4265_07740)	-	1628420..1629919 (+)	1500	WP_053308655.1	C69 family dipeptidase	-
A4265_RS09225 (A4265_08890)	-	1630302..1630577 (+)	276	Protein_1528	NUDIX domain-containing protein	-
A4265_RS08155 (A4265_07745)	-	1630624..1630929 (-)	306	WP_111676844.1	helix-turn-helix domain-containing protein	-
A4265_RS08160 (A4265_07750)	groL	1631131..1632762 (-)	1632	WP_002982320.1	chaperonin GroEL	-
A4265_RS08165 (A4265_07755)	groES	1632798..1633088 (-)	291	WP_002991292.1	co-chaperone GroES	-
A4265_RS08170 (A4265_07760)	clpC	1633266..1635710 (-)	2445	WP_063632169.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
A4265_RS08175 (A4265_07765)	-	1635710..1636171 (-)	462	WP_023610213.1	CtsR family transcriptional regulator	-
A4265_RS08180 (A4265_07770)	-	1636367..1636570 (-)	204	WP_002991299.1	cold-shock protein	-
A4265_RS08190 (A4265_07780)	ahpC	1637556..1638116 (+)	561	WP_002982304.1	alkyl hydroperoxide reductase subunit C	-
A4265_RS08195 (A4265_07785)	ahpF	1638137..1639669 (+)	1533	WP_053308659.1	alkyl hydroperoxide reductase subunit F	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90614.29 Da
• Isoelectric Point: 6.9601

>NTDB_id=177920 A4265_RS08170 WP_063632169.1 1633266..1635710(-) (clpC) [Streptococcus pyogenes strain NS53]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAADNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDDAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA

Nucleotide

• Length: 2445 bp

>NTDB_id=177920 A4265_RS08170 WP_063632169.1 1633266..1635710(-) (clpC) [Streptococcus pyogenes strain NS53]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGCAGATAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACCTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATCATGGCGAGTCGTTTGTTAGAAATAGCAGGCTATC
AGATAAAAGATAACGGCAATGGGCAGCCGCGATTAGCTGACTTACGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATCAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGTGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATATCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAAGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTGACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGTAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GCAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGACGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTCCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGCGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAGCTATGG
AGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGTGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATTCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-130)

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• AAA lid domain (AAA_lid_9) (376-459)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	75.031	99.877	0.749
clpC	Streptococcus thermophilus LMG 18311	71.078	100	0.713
clpC	Streptococcus thermophilus LMD-9	70.956	100	0.711
clpC	Streptococcus pneumoniae TIGR4	65.848	100	0.658
clpC	Streptococcus pneumoniae Rx1	65.848	100	0.658
clpC	Streptococcus pneumoniae D39	65.848	100	0.658
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.733	100	0.491
clpC	Bacillus subtilis subsp. subtilis str. 168	42.206	100	0.432