Detailed information NTG0177910

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: A4265_RS05935
• Genome accession: NZ_CP015238
• Coordinates: 1178233..1179270 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NS53
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1173233..1184270

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A4265_RS05915 (A4265_05605)	-	1173983..1174609 (+)	627	WP_002989076.1	prepilin peptidase	-
A4265_RS05920 (A4265_05610)	rlmN	1174691..1175770 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
A4265_RS05925 (A4265_05615)	-	1175774..1176394 (-)	621	WP_023610891.1	YutD family protein	-
A4265_RS05930 (A4265_05620)	-	1176842..1177819 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
A4265_RS05935 (A4265_05625)	sepM	1178233..1179270 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
A4265_RS05940 (A4265_05630)	coaD	1179257..1179748 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
A4265_RS05945 (A4265_05635)	rsmD	1179738..1180277 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
A4265_RS05950 (A4265_05640)	asnA	1180400..1181392 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
A4265_RS05955 (A4265_05645)	arcC	1181705..1182655 (-)	951	WP_063631992.1	carbamate kinase	-
A4265_RS05960 (A4265_05650)	-	1182675..1184006 (-)	1332	WP_009880963.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=177910 A4265_RS05935 WP_010922499.1 1178233..1179270(-) (sepM) [Streptococcus pyogenes strain NS53]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=177910 A4265_RS05935 WP_010922499.1 1178233..1179270(-) (sepM) [Streptococcus pyogenes strain NS53]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693