Detailed information NTG0174137

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CKU_RS09190
• Genome accession: NZ_CP014791
• Coordinates: 1859550..1860593 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MCRF184
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1854550..1865593

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CKU_RS09160 (CKU_1692)	-	1854971..1856218 (-)	1248	WP_000656302.1	aminopeptidase	-
CKU_RS09165 (CKU_1693)	-	1856230..1856430 (-)	201	WP_000180459.1	DUF1128 family protein	-
CKU_RS09170 (CKU_1694)	-	1856577..1857041 (+)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
CKU_RS09175 (CKU_1695)	-	1857048..1857323 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CKU_RS09180 (CKU_1696)	-	1857601..1858818 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
CKU_RS09185 (CKU_1697)	vraR	1858931..1859560 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CKU_RS09190 (CKU_1698)	vraS	1859550..1860593 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CKU_RS09195 (CKU_1699)	liaF	1860590..1861291 (-)	702	WP_000149067.1	cell wall-active antibiotics response protein LiaF	-
CKU_RS09200 (CKU_1700)	-	1861306..1861692 (-)	387	WP_001110184.1	hypothetical protein	-
CKU_RS09205 (CKU_1701)	map	1861909..1862667 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
CKU_RS09210 (CKU_1702)	-	1863254..1864240 (+)	987	WP_000999713.1	FUSC family protein	-
CKU_RS09215 (CKU_1703)	-	1864418..1864831 (-)	414	WP_001622129.1	hypothetical protein	-
CKU_RS09220	-	1864860..1864969 (-)	110	Protein_1754	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=174137 CKU_RS09190 WP_001017131.1 1859550..1860593(-) (vraS) [Staphylococcus aureus strain MCRF184]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=174137 CKU_RS09190 WP_001017131.1 1859550..1860593(-) (vraS) [Staphylococcus aureus strain MCRF184]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1