Detailed information NTG0171167

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AYM25_RS10530
• Genome accession: NZ_CP014407
• Coordinates: 2030192..2031235 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain USA300-SUR12
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2025192..2036235

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AYM25_RS10500 (AYM25_10225)	-	2025610..2026866 (-)	1257	WP_001795438.1	aminopeptidase	-
AYM25_RS10505 (AYM25_10230)	-	2026869..2027069 (-)	201	WP_000180461.1	DUF1128 family protein	-
AYM25_RS10510 (AYM25_10235)	-	2027216..2027680 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AYM25_RS10515 (AYM25_10240)	-	2027687..2027962 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AYM25_RS10520 (AYM25_10245)	-	2028240..2029457 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
AYM25_RS10525 (AYM25_10250)	vraR	2029573..2030202 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
AYM25_RS10530 (AYM25_10255)	vraS	2030192..2031235 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AYM25_RS10535 (AYM25_10260)	liaF	2031232..2031933 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AYM25_RS10540 (AYM25_10265)	-	2031948..2032334 (-)	387	WP_001110179.1	hypothetical protein	-
AYM25_RS10545 (AYM25_10270)	map	2032551..2033309 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AYM25_RS10550 (AYM25_10280)	-	2033837..2034823 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
AYM25_RS10560 (AYM25_10285)	-	2035254..2035667 (-)	414	WP_001549145.1	hypothetical protein	-
AYM25_RS10565 (AYM25_10290)	-	2035696..2035806 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=171167 AYM25_RS10530 WP_001017131.1 2030192..2031235(-) (vraS) [Staphylococcus aureus strain USA300-SUR12]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=171167 AYM25_RS10530 WP_001017131.1 2030192..2031235(-) (vraS) [Staphylococcus aureus strain USA300-SUR12]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1