Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   AXE83_RS09635 Genome accession   NZ_CP014264
Coordinates   2059973..2062405 (-) Length   810 a.a.
NCBI ID   WP_060956271.1    Uniprot ID   A0A0X8JZL9
Organism   Streptococcus sp. oral taxon 431 strain F0610 (5-114)     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2057881..2079269 2059973..2062405 within 0


Gene organization within MGE regions


Location: 2057881..2079269
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AXE83_RS09625 (AXE83_09625) pnuC 2057881..2058657 (-) 777 WP_060956269.1 nicotinamide riboside transporter PnuC -
  AXE83_RS09630 (AXE83_09630) - 2058667..2059725 (-) 1059 WP_060956270.1 AAA family ATPase -
  AXE83_RS09635 (AXE83_09635) clpC 2059973..2062405 (-) 2433 WP_060956271.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  AXE83_RS09640 (AXE83_09640) - 2062412..2062870 (-) 459 WP_001237459.1 CtsR family transcriptional regulator -
  AXE83_RS09645 (AXE83_09645) - 2063283..2063675 (-) 393 WP_060956272.1 hypothetical protein -
  AXE83_RS09650 (AXE83_09650) - 2063712..2064530 (-) 819 WP_083501014.1 hypothetical protein -
  AXE83_RS09655 (AXE83_09655) - 2064530..2064784 (-) 255 WP_060956273.1 hypothetical protein -
  AXE83_RS09660 (AXE83_09660) - 2064934..2065374 (-) 441 WP_060956274.1 hypothetical protein -
  AXE83_RS09665 (AXE83_09665) - 2066000..2067454 (-) 1455 WP_060956275.1 virulence-associated E family protein -
  AXE83_RS09670 (AXE83_09670) - 2067447..2067962 (-) 516 WP_060956276.1 hypothetical protein -
  AXE83_RS09675 (AXE83_09675) - 2067953..2068222 (-) 270 WP_060956277.1 hypothetical protein -
  AXE83_RS09680 (AXE83_09680) - 2068224..2068433 (-) 210 WP_060956278.1 hypothetical protein -
  AXE83_RS09685 (AXE83_09685) - 2068435..2068635 (-) 201 WP_060956279.1 hypothetical protein -
  AXE83_RS09690 (AXE83_09690) - 2068632..2069084 (-) 453 WP_060956280.1 hypothetical protein -
  AXE83_RS11305 - 2069292..2069441 (-) 150 WP_000391636.1 hypothetical protein -
  AXE83_RS09695 (AXE83_09695) - 2069444..2069872 (-) 429 WP_033630516.1 hypothetical protein -
  AXE83_RS09700 (AXE83_09700) - 2069991..2070245 (-) 255 WP_060956281.1 hypothetical protein -
  AXE83_RS09705 (AXE83_09705) - 2070499..2070684 (-) 186 WP_060956282.1 hypothetical protein -
  AXE83_RS11470 - 2070827..2071477 (+) 651 WP_083501016.1 helix-turn-helix transcriptional regulator -
  AXE83_RS09715 (AXE83_09715) - 2071493..2071762 (+) 270 WP_000505375.1 DUF4177 domain-containing protein -
  AXE83_RS09720 (AXE83_09720) - 2071990..2073234 (+) 1245 WP_335338455.1 Fic family protein -
  AXE83_RS09725 (AXE83_09725) - 2073351..2074512 (+) 1162 Protein_1893 site-specific integrase -
  AXE83_RS09730 (AXE83_09730) - 2074668..2075396 (-) 729 WP_060956283.1 ABC transporter ATP-binding protein -
  AXE83_RS09735 (AXE83_09735) - 2075396..2076403 (-) 1008 WP_060956284.1 ABC transporter substrate-binding protein -
  AXE83_RS09740 (AXE83_09740) - 2076441..2077199 (-) 759 WP_060956285.1 ABC transporter permease -
  AXE83_RS09745 (AXE83_09745) - 2077162..2077452 (-) 291 WP_000647682.1 thiamine-binding protein -
  AXE83_RS09750 (AXE83_09750) cls 2077737..2079269 (-) 1533 WP_060956286.1 cardiolipin synthase -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90156.14 Da        Isoelectric Point: 6.2574

>NTDB_id=170036 AXE83_RS09635 WP_060956271.1 2059973..2062405(-) (clpC) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
MKYSKALTECIDSAFLVASHFGAEYLESWHLLIAMANHSYSVAGATLNEFPYEIDRLEEVAVELTETKYSDKENYQELPF
SHRLKVLLLEAEHVASVVHAKVLGTEHVLYAILHDGNALATRILEKAGFSYEDQKDQVKIAGLRRSLEARAGWTRDDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDQEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIANGDVPNEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGKVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVMIEEPSLADSMAILQGLKATYEKHHHVQITDDAVET
AVKMAHRYLTSRHLPDSAIDLLDETAATVQNKSKHAKQDESGLTPADKALMDGKWKQAAQLIAKEQEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQEQAVSSISRAIRRNQSGIRNNKRPIGSFMFLGSTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
QDMQEVVKIMVKPLIASLAEKGIDLKLQASALKLLAQQGYDPEMGARPLRRTLQTEVEDKLAELLLKGELEAGKTLKIGV
KAGQLKFEIV

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=170036 AXE83_RS09635 WP_060956271.1 2059973..2062405(-) (clpC) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
ATGAAATATTCAAAAGCATTGACAGAATGTATAGACAGTGCCTTTCTGGTCGCAAGTCATTTTGGAGCAGAATACCTAGA
GTCTTGGCACCTATTGATTGCTATGGCCAATCATAGTTACAGTGTAGCTGGGGCAACTTTAAACGAATTTCCATATGAGA
TTGATCGTCTGGAGGAAGTTGCTGTAGAGCTGACTGAAACAAAGTATAGCGATAAGGAAAATTATCAGGAGTTGCCTTTT
TCACACCGTTTGAAGGTATTGTTGTTGGAAGCAGAGCACGTTGCTTCTGTCGTTCATGCCAAGGTTTTAGGAACAGAGCA
CGTGCTTTATGCTATCTTACATGATGGCAATGCCTTAGCTACTCGCATTCTAGAAAAAGCGGGATTTTCTTACGAAGATC
AGAAGGATCAGGTCAAGATTGCTGGACTTCGTCGTAGTCTTGAAGCGCGTGCTGGTTGGACTAGAGATGATTTGAAGGCC
CTTCGTCAACGCCATCGTACGGTAGCGGACAAGCAAAATTCTATGGCTAATATGATGGGCATGCCACAGACCCCAAGTGG
AGGTTTGGAAGATTATACGCATGACCTTACGGAGCAAGCTCGCTCAGGTAAATTGGAACCAGTCATCGGGCGTGACCAAG
AAATCTCTCGTATGATTCAAATTCTGAGTCGTAAGACCAAAAATAATCCGGTCCTAGTTGGAGATGCGGGTGTGGGTAAA
ACAGCTTTGGCACTTGGTCTTGCACAACGTATTGCCAATGGAGATGTGCCAAATGAAATGGCAAAGATGCGAGTTCTAGA
GCTTGATTTGATGAATGTGGTTGCGGGAACTCGTTTCCGTGGTGATTTTGAAGAACGTATGAACAATATCATCAAAGATA
TTGAGGAAGATGGAAAGGTCATCCTCTTTATCGATGAGCTGCATACCATTATGGGTTCAGGAAGTGGGATTGATTCGACC
TTGGATGCGGCCAATATCCTAAAACCTGCCTTGGCACGTGGAACTCTGAGAACTGTCGGTGCGACCACTCAGGAAGAGTA
TCAAAAGCACATCGAAAAAGACGCAGCCCTTTCTCGTCGTTTTGCTAAAGTGATGATTGAGGAGCCAAGTTTAGCAGATA
GTATGGCTATTTTGCAGGGCTTGAAAGCAACTTATGAGAAGCACCACCATGTCCAAATTACAGACGATGCAGTCGAAACA
GCTGTCAAAATGGCACATCGTTATTTGACGAGTCGTCATTTGCCAGACTCAGCAATCGATCTTTTGGATGAAACGGCAGC
AACAGTGCAAAATAAATCGAAACACGCTAAACAAGATGAGTCAGGTTTAACACCAGCTGATAAGGCCTTGATGGATGGTA
AATGGAAGCAAGCTGCTCAACTCATTGCAAAAGAACAGGAAGTACCTGTTTATAAAGATTTGGTGACAGAATCAGATATT
TTGACCACCTTGAGTCGCTTGTCAGGTATTCCAGTTCAAAAATTGACCCAAACAGATGCCAAGAAGTATCTCAATCTTGA
AGCTGAACTGCATAAACGTGTTATCGGACAGGAACAAGCTGTATCTAGTATCAGTCGTGCCATTCGCCGAAATCAATCGG
GTATTCGCAATAACAAACGTCCAATTGGCTCCTTTATGTTCCTAGGATCAACAGGTGTTGGTAAGACAGAATTGGCCAAG
GCCTTGGCGGAAGTTCTCTTTGATGATGAGTCTGCTCTTATCCGCTTTGACATGAGTGAATATATGGAGAAATTTGCAGC
CAGTCGTCTCAATGGAGCTCCTCCAGGTTATGTAGGTTATGAAGAAGGCGGGGAGTTGACTGAGAAGGTTCGCAACAAAC
CATACTCAGTCTTGCTCTTTGACGAGGTAGAAAAGGCTCACCCAGACATCTTTAACGTGCTCTTGCAAGTCTTGGATGAT
GGTGTCTTGACAGATAGTAAAGGTCGTAAGGTTGACTTCTCCAATACCATTATCATCATGACTTCAAACCTTGGTGCGAC
AGCGCTTCGTGATGACAAGACAGTTGGTTTTGGAGCTAAGGACATTCGCTTTGACCAAGAAAATATGGAAAAACGTATGT
TTGAGGAGTTGAAAAAGGCTTATCGTCCAGAGTTTATCAATCGTATTGATGAGAAGGTAGTCTTCCATAGCTTGTCAAGT
CAAGATATGCAAGAAGTAGTTAAGATTATGGTCAAACCATTGATTGCTAGTCTTGCAGAAAAAGGAATTGACTTGAAACT
CCAAGCATCTGCCCTTAAACTTCTAGCTCAGCAAGGCTATGATCCAGAGATGGGGGCTCGTCCACTTCGTAGAACCCTAC
AAACGGAAGTGGAAGACAAACTTGCAGAGCTTCTCCTTAAAGGTGAATTGGAAGCTGGCAAGACTCTGAAGATTGGTGTC
AAAGCTGGTCAATTAAAATTTGAGATTGTTTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-798)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(103-137)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(14-60)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-364)

AAA lid domain (AAA_lid_9)

(371-441)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0X8JZL9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae D39

92.583

99.877

0.925
  clpC Streptococcus pneumoniae TIGR4

92.583

99.877

0.925
  clpC Streptococcus pneumoniae Rx1

92.583

99.877

0.925
  clpC Streptococcus mutans UA159

67.405

100

0.677
  clpC Streptococcus thermophilus LMD-9

66.258

100

0.667
  clpC Streptococcus thermophilus LMG 18311

66.135

100

0.665
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

50.06

100

0.511
  clpC Bacillus subtilis subsp. subtilis str. 168

45.018

100

0.452
  clpE Streptococcus mutans UA159

48.065

76.543

0.368

Multiple sequence alignment