Detailed information NTG0169042

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: BIZ52_RS08455
• Genome accession: NZ_CP017457
• Coordinates: 1887309..1889885 (+)
• Length: 858 a.a.
• NCBI ID: WP_027227880.1
• Uniprot ID: -
• Organism: Legionella pneumophila subsp. fraseri strain Detroit-1
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1882309..1894885

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BIZ52_RS08425 (BIZ52_08340)	-	1882576..1882941 (-)	366	WP_027227886.1	iron-sulfur cluster assembly accessory protein	-
BIZ52_RS08430 (BIZ52_08345)	-	1882946..1883329 (-)	384	WP_027227885.1	iron-sulfur cluster assembly scaffold protein	-
BIZ52_RS08435 (BIZ52_08350)	-	1883326..1884459 (-)	1134	WP_050598569.1	IscS subfamily cysteine desulfurase	-
BIZ52_RS08440 (BIZ52_08355)	trmJ	1884464..1885237 (-)	774	WP_027227883.1	tRNA (cytosine(32)/uridine(32)-2'-O)-methyltransferase TrmJ	-
BIZ52_RS08445 (BIZ52_08360)	-	1885353..1886138 (+)	786	WP_027227882.1	inositol monophosphatase family protein	-
BIZ52_RS08450 (BIZ52_08365)	-	1886264..1887220 (-)	957	WP_027227881.1	S49 family peptidase	-
BIZ52_RS08455 (BIZ52_08370)	clpC	1887309..1889885 (+)	2577	WP_027227880.1	ATP-dependent chaperone ClpB	Regulator
BIZ52_RS08460 (BIZ52_08375)	-	1889979..1891292 (-)	1314	WP_027227879.1	lpg1751 family Dot/Icm T4SS effector	-
BIZ52_RS08465 (BIZ52_08380)	-	1891305..1891952 (-)	648	WP_080272157.1	lpg1752 family Dot/Icm T4SS effector	-
BIZ52_RS08470 (BIZ52_08385)	mpl	1892108..1893493 (-)	1386	WP_027227877.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
BIZ52_RS08475 (BIZ52_08390)	-	1893495..1894043 (-)	549	WP_027227876.1	hypothetical protein	-

Sequence

Protein

• Length: 858 a.a.
• Molecular weight: 95806.65 Da
• Isoelectric Point: 5.3681

>NTDB_id=169042 BIZ52_RS08455 WP_027227880.1 1887309..1889885(+) (clpC) [Legionella pneumophila subsp. fraseri strain Detroit-1]
MRMDKLTSKFQMALAEAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFDYDQIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITLEVTSEAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGETIIVSYKDGVMEFSKQ

Nucleotide

• Length: 2577 bp

>NTDB_id=169042 BIZ52_RS08455 WP_027227880.1 1887309..1889885(+) (clpC) [Legionella pneumophila subsp. fraseri strain Detroit-1]
ATGCGAATGGACAAACTAACATCAAAGTTTCAAATGGCTCTTGCAGAGGCCCAATCCCTGGCCTTAGGTAGAGATAATGG
ATTTATAGAACCAGAACATTTAATGAAAGCCTTACTCGATCAACAAGGTGGAAGTTGCAGACCTCTTCTCAGTAAAGCGG
GTGTTAATATACCACTATTAAGAACCTTAATTGACCAAGCTCTGGATAAACTCCCTAAAGTATCAGGTACCGGAGGAGAT
ATTCATATATCTAATGCATTGAATAGACTACTTAACCTGACTGACAAATTATCGCAACAAAGAAAAGATAACTTTATTTC
AAGTGAGCTTTTTATATTAGCAGCGATAAATGAGGATAGTAACCTTGCGAAAATACTCAAGCAAGCCGGAGGTGACAACA
AAGCCATTGAAAAAGCGATTGATGAGTTAAGAGGCGGAGAAACTGTTAATGATCCAAATGCAGAGGAACAGCGACAAGCC
CTTGAAAAATATACCCTGGATTTGACTGAACGTGCTGAGCAAGGAAAACTAGACCCAGTTATTGGACGAGATGATGAAAT
TCGACGCACCATCCAGGTATTGCAAAGAAGAACCAAAAATAACCCTGTATTAATAGGTGAACCTGGTGTGGGTAAAACAG
CTATAGTAGAAGGTTTGGCGCAACGAATTATTAATGGTGAAGTGCCTGAAGGATTAAAGAATAAGCGCTTACTGGCACTG
GACATGGGAGCTTTGATCGCGGGTGCAAAATATCGCGGAGAGTTTGAAGAACGTTTAAAAGGAGTTCTTAATGATTTGGC
AAAACAAGAAGGTCAAATCATATTGTTTATTGATGAATTGCATACTATGGTCGGCGCTGGCAAGGCTGAAGGAGCTATGG
ATGCCGGGAATATGCTCAAACCAGCATTGGCTAGAGGTGAATTGCATTGCATTGGGGCTACGACATTAGACGAATACCGA
CAATACATTGAAAAAGATGCTGCCCTTGAAAGACGCTTTCAAAAAGTACTGGTCGATGAACCCAGTGTGGAAGACACCAT
TGCTATATTAAGGGGTCTTAAAGAACGATATGAAGTTCACCATGGAGTTGAAATTACAGATCCTGCTTTGGTTGCTGCAG
CAACGCTATCCCATCGATATATCAGTGACCGCCAACTACCCGACAAAGCCATTGATTTAATTGATGAAGCAGCCAGCTTA
ATCCGGATGGAAATTGATTCAAAACCTGAAAGTATGGATAAACTGGAACGACGTTTGATTCAGCTAAAAATCGAGCGTGA
AGCATTGAAAAAGGAAAATGACGAAGCGTCTAAAAAAAGACTTGTTGATTTACAAAAAAGTATCGATGAATTAGAGCAAA
ATTATTCAGACTTAGAGGAGATTTGGAAAGCTGAAAAAGCGACCATGCAAGGGTCCACCCAAATCAAGGAAGCACTTGAA
CAAGCCAAACTGGAAATGGAAACTGCCAGGAGAGCAGGAGATTTAAGTCGTATGTCTGAATTACAATATGGACGTATACC
CGAGCTGGAAAAGAGATTAAGCCAGGTCTCTTCCGTCGATGCTATGGAAACAAAGTTGGTACGCAATAAAGTCACCGAAG
ATGAGATCGCAGAAGTTGTTTCAAAATGGACAGGGATCCCTGTATCTAAAATGATGGAGGGAGAAAAGGAAAAATTACTG
AAAATGGAAGAGGCTTTGCACAGCAGACTCATCGGCCAAAATGAAGCAGTAGATGCTGTTTCTAATGCCATAAGAAGGTC
ACGTGCAGGCCTGTCTGATCCTAATCGGCCAATTGGTTCATTTCTTTTTCTGGGGCCAACTGGTGTGGGAAAAACTGAAT
TATGTAAAGCACTTGCTTCTTTTCTTTTTGATACGGAAGAGGCTATGGTGCGCATTGATATGTCTGAATTTATGGAAAAA
CACTCTGTTGCGCGCTTAATCGGCGCGCCTCCTGGCTACGTAGGATATGAAGAAGGTGGCTATTTAACTGAGGCAGTCAG
GCGCAGGCCCTATTCTGTTATCTTGCTCGATGAAGTAGAAAAAGCTCATACCGACGTATTTAATATTCTGCTTCAAGTTA
TGGATGATGGCCGTTTAACAGATGGTCAGGGACGTACTGTTGACTTTAGGAATACCGTTATTGTTATGACCTCTAATCTG
GGATCTCAACTCATTCAGGAAATGAGCAGCAAATTTGATTACGATCAGATTAAGGCTGCGGTAATGGATTTAGTCAGCCA
ACATTTCAGACCTGAATTTATCAACAGAATTGATGAATCGGTGGTATTCCATTCCCTGACAAAAGAACAAATTGCAAAAA
TTGCTGCAATCCAGATTAACTATTTACATCATCGGCTGAAACAACAAAACATCACTCTTGAAGTCACAAGTGAGGCTTTA
TCTCATTTGGCTGAAGCAGGTTTTGATCCGGTCTATGGTGCCCGCCCCTTAAAACGTACCATTCAGCAAAAATTAGAGAA
TCCACTGGCGCAATCATTATTGACTGGAAAATTCAAATCAGGGGAAACCATCATTGTATCTTATAAAGATGGAGTAATGG
AATTTTCCAAGCAATGA

Domains

Predicted by InterProScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-759)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-846)

• AAA lid domain (AAA_lid_9) (342-444)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-335)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	46.951	100	0.476
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.176	100	0.416
clpC	Lactococcus lactis subsp. cremoris KW2	46.454	80.536	0.374
clpE	Streptococcus pneumoniae D39	45.428	80.303	0.365
clpE	Streptococcus pneumoniae R6	45.428	80.303	0.365
clpE	Streptococcus pneumoniae TIGR4	45.428	80.303	0.365
clpE	Streptococcus pneumoniae Rx1	45.428	80.303	0.365
clpE	Streptococcus mutans UA159	46.097	79.138	0.365