Detailed information NTG0168543

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AL521_RS09530
• Genome accession: NZ_CP014132
• Coordinates: 1943171..1944217 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain FDAARGOS_161
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1938171..1949217

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AL521_RS09500 (AL521_09500)	-	1938555..1939796 (-)	1242	WP_001832467.1	aminopeptidase	-
AL521_RS09505 (AL521_09505)	-	1939798..1940013 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
AL521_RS09510 (AL521_09510)	-	1940154..1940618 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
AL521_RS09515 (AL521_09515)	-	1940626..1940910 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
AL521_RS09520 (AL521_09520)	-	1941317..1942495 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
AL521_RS09525 (AL521_09525)	vraR	1942552..1943181 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
AL521_RS09530 (AL521_09530)	vraS	1943171..1944217 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
AL521_RS09535 (AL521_09535)	liaF	1944214..1944915 (-)	702	WP_104992878.1	cell wall-active antibiotics response protein LiaF	-
AL521_RS09540 (AL521_09540)	-	1944930..1945316 (-)	387	WP_001830382.1	hypothetical protein	-
AL521_RS09545 (AL521_09545)	map	1945474..1946229 (-)	756	WP_001830397.1	type I methionyl aminopeptidase	-
AL521_RS09550 (AL521_09550)	-	1946403..1947389 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
AL521_RS09555 (AL521_09555)	isaB	1947540..1948076 (-)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=168543 AL521_RS09530 WP_001830374.1 1943171..1944217(-) (vraS) [Staphylococcus epidermidis strain FDAARGOS_161]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=168543 AL521_RS09530 WP_001830374.1 1943171..1944217(-) (vraS) [Staphylococcus epidermidis strain FDAARGOS_161]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92