Detailed information NTG0168434

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AL514_RS00740
• Genome accession: NZ_CP014119
• Coordinates: 67471..68517 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain FDAARGOS_153
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 62471..73517

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AL514_RS00710 (AL514_00770)	-	62855..64096 (-)	1242	WP_002457094.1	aminopeptidase	-
AL514_RS00715 (AL514_00775)	-	64098..64313 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
AL514_RS00720 (AL514_00780)	-	64454..64918 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
AL514_RS00725 (AL514_00785)	-	64926..65210 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
AL514_RS00730 (AL514_00790)	-	65617..66795 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
AL514_RS00735 (AL514_00795)	vraR	66852..67481 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
AL514_RS00740 (AL514_00800)	vraS	67471..68517 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
AL514_RS00745 (AL514_00805)	liaF	68514..69215 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
AL514_RS00750 (AL514_00810)	-	69230..69616 (-)	387	WP_001830382.1	hypothetical protein	-
AL514_RS00755 (AL514_00815)	map	69774..70529 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
AL514_RS00760 (AL514_00820)	-	70703..71689 (+)	987	WP_002457091.1	aromatic acid exporter family protein	-
AL514_RS00765 (AL514_00825)	isaB	71840..72376 (-)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=168434 AL514_RS00740 WP_001830374.1 67471..68517(-) (vraS) [Staphylococcus epidermidis strain FDAARGOS_153]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=168434 AL514_RS00740 WP_001830374.1 67471..68517(-) (vraS) [Staphylococcus epidermidis strain FDAARGOS_153]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92