Detailed information NTG0167530

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: AL510_RS06935
• Genome accession: NZ_CP014027
• Coordinates: 1358980..1360017 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain FDAARGOS_149
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1353980..1365017

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AL510_RS06910 (AL510_06690)	-	1354244..1355575 (+)	1332	WP_011285641.1	dipeptidase	-
AL510_RS06915 (AL510_06695)	arcC	1355595..1356545 (+)	951	WP_010922501.1	carbamate kinase	-
AL510_RS06920 (AL510_06700)	asnA	1356858..1357850 (+)	993	WP_010922500.1	aspartate--ammonia ligase	-
AL510_RS06925 (AL510_06705)	rsmD	1357973..1358512 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
AL510_RS06930 (AL510_06710)	coaD	1358502..1358993 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
AL510_RS06935 (AL510_06715)	sepM	1358980..1360017 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
AL510_RS06940 (AL510_06720)	-	1360431..1361407 (+)	977	Protein_1263	LacI family DNA-binding transcriptional regulator	-
AL510_RS06945 (AL510_06725)	-	1361855..1362475 (+)	621	WP_011285637.1	YutD family protein	-
AL510_RS06950 (AL510_06730)	rlmN	1362479..1363558 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
AL510_RS06955 (AL510_06735)	-	1363640..1364266 (-)	627	WP_010922497.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=167530 AL510_RS06935 WP_010922499.1 1358980..1360017(+) (sepM) [Streptococcus pyogenes strain FDAARGOS_149]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=167530 AL510_RS06935 WP_010922499.1 1358980..1360017(+) (sepM) [Streptococcus pyogenes strain FDAARGOS_149]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693