Detailed information NTG0167393

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AL499_RS11820
• Genome accession: NZ_CP014022
• Coordinates: 2515817..2516860 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain FDAARGOS_141
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2510817..2521860

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AL499_RS11795 (AL499_11800)	-	2511107..2512468 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
AL499_RS11800 (AL499_11805)	-	2512602..2513582 (-)	981	WP_002492696.1	FUSC family protein	-
AL499_RS11805 (AL499_11810)	map	2513827..2514582 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
AL499_RS11810 (AL499_11815)	-	2514708..2515094 (+)	387	WP_002477960.1	hypothetical protein	-
AL499_RS11815 (AL499_11820)	liaF	2515119..2515820 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
AL499_RS11820 (AL499_11825)	vraS	2515817..2516860 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
AL499_RS11825 (AL499_11830)	vraR	2516850..2517479 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
AL499_RS11830 (AL499_11835)	-	2517652..2518881 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
AL499_RS11835 (AL499_11840)	-	2519084..2519368 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
AL499_RS11840 (AL499_11845)	-	2519375..2519839 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
AL499_RS11845 (AL499_11850)	-	2520003..2520188 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
AL499_RS11850 (AL499_11855)	-	2520258..2521439 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=167393 AL499_RS11820 WP_002461334.1 2515817..2516860(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_141]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=167393 AL499_RS11820 WP_002461334.1 2515817..2516860(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_141]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911