Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | ASL17_RS00460 | Genome accession | NZ_CP013957 |
| Coordinates | 94910..96256 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain V521 isolate Sequencing | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 40889..96256 | 94910..96256 | within | 0 |
Gene organization within MGE regions
Location: 40889..96256
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASL17_RS00165 (ASL17_00165) | ccrC | 40889..42574 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| ASL17_RS00170 (ASL17_00170) | tnpA | 42622..43107 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| ASL17_RS00175 (ASL17_00175) | - | 43399..43737 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ASL17_RS00180 (ASL17_00180) | - | 43831..44142 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| ASL17_RS00185 (ASL17_00185) | - | 44158..44664 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| ASL17_RS00190 (ASL17_00190) | - | 44685..45002 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| ASL17_RS00195 (ASL17_00195) | - | 45121..46206 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| ASL17_RS00200 (ASL17_00200) | - | 46203..48095 (+) | 1893 | Protein_37 | site-specific integrase | - |
| ASL17_RS00210 (ASL17_00210) | - | 48102..48479 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| ASL17_RS00215 (ASL17_00215) | - | 48630..49412 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| ASL17_RS00220 (ASL17_00220) | erm(A) | 49538..50269 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| ASL17_RS17515 | - | 50327..50386 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| ASL17_RS00225 (ASL17_00225) | - | 50778..51440 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| ASL17_RS17315 | - | 51672..51818 (+) | 147 | Protein_43 | JAB domain-containing protein | - |
| ASL17_RS00230 (ASL17_00230) | - | 51988..52860 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| ASL17_RS00235 (ASL17_00235) | - | 52917..53207 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| ASL17_RS00240 (ASL17_00240) | - | 53223..53711 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| ASL17_RS00245 (ASL17_00245) | - | 53846..54373 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| ASL17_RS00250 (ASL17_00250) | - | 54436..54852 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| ASL17_RS17145 | - | 55141..55305 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| ASL17_RS00255 (ASL17_00255) | - | 55319..55540 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| ASL17_RS00260 (ASL17_00260) | - | 55690..56256 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| ASL17_RS00265 (ASL17_00265) | - | 56336..58549 (-) | 2214 | Protein_52 | type I restriction endonuclease subunit R | - |
| ASL17_RS00270 (ASL17_00270) | - | 58611..59285 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| ASL17_RS00275 (ASL17_00275) | - | 59568..60914 (+) | 1347 | WP_044119879.1 | dihydrolipoyl dehydrogenase family protein | - |
| ASL17_RS00280 (ASL17_00280) | merR | 61214..61621 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| ASL17_RS00285 (ASL17_00285) | - | 61638..61991 (+) | 354 | WP_000746201.1 | TlpA family protein disulfide reductase | - |
| ASL17_RS00290 (ASL17_00290) | - | 61988..62668 (+) | 681 | WP_000010351.1 | cytochrome c biogenesis CcdA family protein | - |
| ASL17_RS00295 (ASL17_00295) | - | 62803..63141 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| ASL17_RS00300 (ASL17_00300) | merA | 63199..64842 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| ASL17_RS00305 (ASL17_00305) | merB | 64924..65574 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| ASL17_RS00310 (ASL17_00310) | - | 65769..66284 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| ASL17_RS00315 (ASL17_00315) | - | 66403..67077 (-) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| ASL17_RS00320 (ASL17_00320) | tet(K) | 67275..68654 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| ASL17_RS00325 (ASL17_00325) | mobV | 68843..70084 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| ASL17_RS16155 | - | 70611..71565 (+) | 955 | Protein_65 | replication initiation factor domain-containing protein | - |
| ASL17_RS00340 (ASL17_00340) | - | 71654..72328 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| ASL17_RS16160 | - | 72364..72753 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| ASL17_RS00350 (ASL17_00350) | - | 73830..74573 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| ASL17_RS00355 (ASL17_00355) | - | 74670..75098 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| ASL17_RS00360 (ASL17_00360) | mecA | 75144..77153 (-) | 2010 | WP_078056052.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| ASL17_RS00365 (ASL17_00365) | mecR1 | 77250..79007 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| ASL17_RS00370 (ASL17_00370) | mecI | 79007..79378 (+) | 372 | Protein_72 | mecA-type methicillin resistance repressor MecI | - |
| ASL17_RS16920 | psm-mec | 79463..79531 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| ASL17_RS00375 (ASL17_00375) | - | 79851..80999 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| ASL17_RS00385 (ASL17_00385) | cstB | 81113..82447 (-) | 1335 | Protein_75 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ASL17_RS00390 (ASL17_00390) | - | 82479..83543 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| ASL17_RS00395 (ASL17_00395) | cstR | 83679..83939 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| ASL17_RS00400 (ASL17_00400) | - | 83939..84577 (+) | 639 | Protein_78 | sulfite exporter TauE/SafE family protein | - |
| ASL17_RS00405 (ASL17_00405) | - | 84851..85468 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| ASL17_RS00410 (ASL17_00410) | - | 85549..87964 (-) | 2416 | Protein_80 | heavy metal translocating P-type ATPase | - |
| ASL17_RS00415 (ASL17_00415) | - | 87957..88322 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| ASL17_RS00420 (ASL17_00420) | - | 88508..88885 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| ASL17_RS00425 (ASL17_00425) | - | 88892..90785 (-) | 1894 | Protein_83 | site-specific integrase | - |
| ASL17_RS00430 (ASL17_00430) | - | 90980..91303 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| ASL17_RS00435 (ASL17_00435) | - | 91296..91502 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| ASL17_RS00440 (ASL17_00440) | - | 91504..92025 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| ASL17_RS00445 (ASL17_00445) | - | 92044..92355 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| ASL17_RS00450 (ASL17_00450) | - | 92440..92790 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ASL17_RS00455 (ASL17_00455) | ccrB | 93261..94889 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| ASL17_RS00460 (ASL17_00460) | ccrA | 94910..96256 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=166639 ASL17_RS00460 WP_000816499.1 94910..96256(-) (ccrA) [Staphylococcus aureus strain V521 isolate Sequencing]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=166639 ASL17_RS00460 WP_000816499.1 94910..96256(-) (ccrA) [Staphylococcus aureus strain V521 isolate Sequencing]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |