Detailed information NTG0166040

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: A7J08_RS06320
• Genome accession: NZ_CP017088
• Coordinates: 1265975..1266715 (-)
• Length: 246 a.a.
• NCBI ID: WP_014638212.1
• Uniprot ID: -
• Organism: Streptococcus suis strain SRD478
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1260975..1271715

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7J08_RS06305 (A7J08_06140)	comB	1262832..1264190 (+)	1359	WP_148115784.1	bacteriocin secretion accessory protein	Regulator
A7J08_RS06310	-	1264292..1264453 (+)	162	WP_014638210.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
A7J08_RS06315 (A7J08_06145)	-	1264621..1265964 (-)	1344	WP_105105954.1	GHKL domain-containing protein	-
A7J08_RS06320 (A7J08_06150)	comE/blpR	1265975..1266715 (-)	741	WP_014638212.1	response regulator transcription factor	Regulator
A7J08_RS06325 (A7J08_06155)	-	1266727..1267059 (-)	333	WP_014638213.1	LytTR family DNA-binding domain-containing protein	-
A7J08_RS10630	-	1267252..1267638 (+)	387	WP_014638214.1	hypothetical protein	-
A7J08_RS10635	-	1267580..1269165 (-)	1586	Protein_1179	SAG1250 family conjugative relaxase	-
A7J08_RS06345 (A7J08_06175)	-	1269285..1269902 (-)	618	WP_014638217.1	SAP domain-containing protein	-
A7J08_RS06350	-	1269915..1270103 (-)	189	Protein_1181	hypothetical protein	-
A7J08_RS06355 (A7J08_06180)	rlmD	1270176..1271534 (-)	1359	WP_148115786.1	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28874.95 Da
• Isoelectric Point: 5.6240

>NTDB_id=166040 A7J08_RS06320 WP_014638212.1 1265975..1266715(-) (comE/blpR) [Streptococcus suis strain SRD478]
MNIFILEDDFFQQTRMENIVRQIVSDKQIGVKHFEVYGKPGQLLEDITERGGHQLFFLDIEIKDDKKKGLDLALEIRRKD
PHAEIVFVTTHSEFMPVSFQYHVSALDFIDKELSEKQFIERIEQSIDYVQNQQGQTLAEDSFIFKNAKTQVQIPFADLLY
IETSYIAHKLVLYSTRERIEFYGELSEIVKQEPRLFQCHRSYVVNPYNISSINRDERLVYLKNGSTCMVSRLKITALKEA
VENLHT

Nucleotide

• Length: 741 bp

>NTDB_id=166040 A7J08_RS06320 WP_014638212.1 1265975..1266715(-) (comE/blpR) [Streptococcus suis strain SRD478]
ATGAATATCTTTATACTTGAAGATGATTTTTTTCAACAAACTCGAATGGAAAATATTGTTCGTCAAATAGTATCTGATAA
ACAAATTGGTGTCAAACATTTTGAAGTTTATGGAAAACCAGGTCAACTTTTAGAAGATATTACTGAAAGAGGAGGACATC
AACTTTTCTTTCTGGATATTGAAATCAAGGATGACAAGAAAAAAGGTTTAGATTTAGCTCTAGAGATTAGGCGAAAAGAT
CCTCATGCTGAAATTGTGTTTGTGACAACTCACTCAGAGTTTATGCCAGTTTCTTTCCAGTATCATGTTTCTGCTCTAGA
CTTTATTGATAAAGAATTATCGGAAAAACAGTTCATTGAGCGCATTGAACAATCAATTGACTATGTTCAAAATCAACAGG
GGCAAACTTTAGCTGAAGATTCATTTATTTTTAAAAACGCTAAGACTCAGGTTCAGATTCCATTTGCTGATTTACTTTAT
ATTGAAACATCATACATTGCCCATAAGCTGGTTCTTTATTCTACTAGAGAAAGGATTGAATTTTATGGTGAGTTATCTGA
AATAGTTAAACAAGAACCAAGATTATTTCAATGTCATCGCTCGTATGTTGTAAATCCCTATAATATATCATCCATCAATC
GAGACGAACGATTGGTTTACCTAAAAAATGGTTCGACATGTATGGTATCAAGGTTAAAGATTACTGCACTCAAAGAAGCA
GTCGAAAACCTTCATACATAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.869	99.187	0.524
comE/comE1	Streptococcus equinus JB1	40.928	96.341	0.394
comE/comE2	Streptococcus equinus JB1	38.115	99.187	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	37.805	100	0.378
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.805	100	0.378
comE	Streptococcus pneumoniae Rx1	36.437	100	0.366
comE	Streptococcus pneumoniae D39	36.437	100	0.366
comE	Streptococcus pneumoniae R6	36.437	100	0.366
comE	Streptococcus pneumoniae TIGR4	36.437	100	0.366
comE	Streptococcus mitis NCTC 12261	36.437	100	0.366
comE	Streptococcus mitis SK321	36.437	100	0.366