Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   AV644_RS04135 Genome accession   NZ_CP013908
Coordinates   750176..750886 (+) Length   236 a.a.
NCBI ID   WP_000722052.1    Uniprot ID   X5K3L1
Organism   Streptococcus agalactiae strain GBS-M002     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 745176..755886
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AV644_RS04110 (AV644_03965) - 746284..746850 (+) 567 WP_000592391.1 PepSY domain-containing protein -
  AV644_RS04115 (AV644_03970) - 746899..747549 (-) 651 WP_000100031.1 amino acid ABC transporter permease -
  AV644_RS04120 (AV644_03975) - 747561..748256 (-) 696 WP_000173642.1 amino acid ABC transporter permease -
  AV644_RS04125 (AV644_03980) - 748269..749069 (-) 801 WP_000946165.1 transporter substrate-binding domain-containing protein -
  AV644_RS04130 (AV644_03985) - 749081..749836 (-) 756 WP_000053145.1 amino acid ABC transporter ATP-binding protein -
  AV644_RS04135 (AV644_03990) vicR 750176..750886 (+) 711 WP_000722052.1 response regulator YycF Regulator
  AV644_RS04140 (AV644_03995) vicK 750879..752228 (+) 1350 WP_001065469.1 cell wall metabolism sensor histidine kinase VicK Regulator
  AV644_RS04145 (AV644_04000) vicX 752232..753041 (+) 810 WP_001289497.1 MBL fold metallo-hydrolase Regulator
  AV644_RS04150 (AV644_04005) - 753044..753412 (+) 369 WP_000719384.1 YbaN family protein -
  AV644_RS04155 (AV644_04010) rnc 753588..754274 (+) 687 WP_000661526.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27063.90 Da        Isoelectric Point: 4.8246

>NTDB_id=165931 AV644_RS04135 WP_000722052.1 750176..750886(+) (vicR) [Streptococcus agalactiae strain GBS-M002]
MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE
LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide


Download         Length: 711 bp        

>NTDB_id=165931 AV644_RS04135 WP_000722052.1 750176..750886(+) (vicR) [Streptococcus agalactiae strain GBS-M002]
ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA
GACGGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA
TGCTTCCTGAACTAGATGGTTTAGAAGTGGCTAAGGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCTGCA
AAAGACAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA
ACTTTTGGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGTGCTCAAAATG
CTTCTTCAGATATTACTATTGGTGAGTTGCAAATTTTACCAGATGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA
TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATCGGACAAGTCATGACACGCGAACATTTATTGGA
AACAGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG
ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB X5K3L1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

88.983

100

0.89
  micA Streptococcus pneumoniae Cp1015

77.778

99.153

0.771
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.983

98.305

0.462
  covR Streptococcus salivarius strain HSISS4

44.635

98.729

0.441
  scnR Streptococcus mutans UA159

38.559

100

0.386

Multiple sequence alignment