Detailed information NTG0165128

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS27061_RS05680
• Genome accession: NZ_CP013840
• Coordinates: 1162449..1163486 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS27061
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1157449..1168486

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS27061_RS05660 (MGAS27061_1159)	-	1158191..1158817 (+)	627	WP_002983834.1	prepilin peptidase	-
MGAS27061_RS05665 (MGAS27061_1160)	rlmN	1158899..1159978 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS27061_RS05670 (MGAS27061_1161)	-	1159982..1160602 (-)	621	WP_002992791.1	YutD family protein	-
MGAS27061_RS05675 (MGAS27061_1162)	-	1161050..1162027 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
MGAS27061_RS05680 (MGAS27061_1163)	sepM	1162449..1163486 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS27061_RS05685 (MGAS27061_1164)	coaD	1163473..1163964 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS27061_RS05690 (MGAS27061_1165)	rsmD	1163954..1164493 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS27061_RS05695 (MGAS27061_1166)	asnA	1164616..1165608 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
MGAS27061_RS05700 (MGAS27061_1167)	arcC	1165921..1166871 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS27061_RS05705 (MGAS27061_1168)	-	1166891..1168222 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=165128 MGAS27061_RS05680 WP_010922499.1 1162449..1163486(-) (sepM) [Streptococcus pyogenes strain MGAS27061]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=165128 MGAS27061_RS05680 WP_010922499.1 1162449..1163486(-) (sepM) [Streptococcus pyogenes strain MGAS27061]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693