Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | MGAS27061_RS05325 | Genome accession | NZ_CP013840 |
| Coordinates | 1088013..1089818 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain MGAS27061 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1067783..1114892 | 1088013..1089818 | within | 0 |
Gene organization within MGE regions
Location: 1067783..1114892
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MGAS27061_RS05235 (MGAS27061_1073) | - | 1067821..1069095 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| MGAS27061_RS05240 (MGAS27061_1074) | - | 1069190..1070617 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| MGAS27061_RS05245 (MGAS27061_1075) | ptsP | 1070802..1072535 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| MGAS27061_RS05250 (MGAS27061_1076) | - | 1072540..1072803 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| MGAS27061_RS05255 (MGAS27061_1077) | - | 1073196..1073414 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| MGAS27061_RS05260 (MGAS27061_1078) | nrdE | 1073434..1075593 (+) | 2160 | WP_031488773.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| MGAS27061_RS05265 (MGAS27061_1080) | nrdF | 1075926..1076885 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| MGAS27061_RS05270 (MGAS27061_1081) | - | 1076947..1078173 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| MGAS27061_RS08845 (MGAS27061_1082) | - | 1078269..1079426 (+) | 1158 | Protein_1024 | IS3 family transposase | - |
| MGAS27061_RS05290 (MGAS27061_1083) | - | 1079518..1080213 (-) | 696 | WP_031488553.1 | CPBP family intramembrane glutamic endopeptidase | - |
| MGAS27061_RS05295 (MGAS27061_1084) | - | 1080232..1080993 (-) | 762 | WP_031488552.1 | DUF3169 family protein | - |
| MGAS27061_RS05300 (MGAS27061_1085) | - | 1080990..1081205 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| MGAS27061_RS05305 (MGAS27061_1087) | alaS | 1081545..1084163 (-) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| MGAS27061_RS05310 (MGAS27061_1088) | prsA | 1084550..1085605 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| MGAS27061_RS05315 (MGAS27061_1089) | - | 1085668..1086375 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| MGAS27061_RS05320 (MGAS27061_1090) | - | 1086441..1087637 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| MGAS27061_RS05325 (MGAS27061_1091) | pepF | 1088013..1089818 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| MGAS27061_RS05330 (MGAS27061_1092) | - | 1089831..1090793 (-) | 963 | WP_031488550.1 | competence protein CoiA | - |
| MGAS27061_RS05335 (MGAS27061_1093) | - | 1091089..1091805 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| MGAS27061_RS05340 (MGAS27061_1094) | nagB | 1091924..1092628 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| MGAS27061_RS05345 (MGAS27061_1095) | queA | 1092830..1093858 (+) | 1029 | WP_031488549.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| MGAS27061_RS05350 (MGAS27061_1096) | - | 1093865..1095085 (+) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| MGAS27061_RS05355 (MGAS27061_1097) | - | 1095279..1095869 (-) | 591 | WP_002983984.1 | serine hydrolase | - |
| MGAS27061_RS09115 (MGAS27061_1098) | - | 1095866..1096093 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| MGAS27061_RS05365 (MGAS27061_1099) | - | 1096094..1096327 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| MGAS27061_RS05370 (MGAS27061_1100) | sodA | 1096494..1097099 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| MGAS27061_RS05375 (MGAS27061_1101) | holA | 1097196..1098236 (-) | 1041 | WP_031488548.1 | DNA polymerase III subunit delta | - |
| MGAS27061_RS05380 (MGAS27061_1102) | - | 1098307..1100550 (-) | 2244 | WP_031488547.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| MGAS27061_RS05385 (MGAS27061_1103) | - | 1100531..1101193 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| MGAS27061_RS05390 (MGAS27061_1104) | - | 1101393..1102133 (-) | 741 | WP_031488546.1 | lysophospholipid acyltransferase family protein | - |
| MGAS27061_RS05395 (MGAS27061_1105) | - | 1102251..1103027 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| MGAS27061_RS05400 (MGAS27061_1106) | - | 1103017..1103295 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| MGAS27061_RS05405 (MGAS27061_1107) | - | 1103319..1105319 (-) | 2001 | WP_031488545.1 | potassium transporter Kup | - |
| MGAS27061_RS05410 (MGAS27061_1108) | - | 1105446..1107065 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| MGAS27061_RS05415 (MGAS27061_1109) | - | 1107372..1108916 (-) | 1545 | WP_031488544.1 | peptide chain release factor 3 | - |
| MGAS27061_RS05420 (MGAS27061_1111) | - | 1109164..1109859 (-) | 696 | WP_031488543.1 | TIGR02206 family membrane protein | - |
| MGAS27061_RS05425 (MGAS27061_1112) | - | 1109939..1111330 (-) | 1392 | WP_031488542.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| MGAS27061_RS05430 (MGAS27061_1113) | - | 1111521..1112567 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| MGAS27061_RS05435 (MGAS27061_1114) | recR | 1112668..1113264 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| MGAS27061_RS09235 | - | 1113311..1113502 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| MGAS27061_RS05445 (MGAS27061_1115) | - | 1114061..1114840 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=165125 MGAS27061_RS05325 WP_011054652.1 1088013..1089818(-) (pepF) [Streptococcus pyogenes strain MGAS27061]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=165125 MGAS27061_RS05325 WP_011054652.1 1088013..1089818(-) (pepF) [Streptococcus pyogenes strain MGAS27061]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |