Detailed information NTG0165076

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS23530_RS05490
• Genome accession: NZ_CP013839
• Coordinates: 1128861..1129898 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS23530
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1123861..1134898

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS23530_RS05470 (MGAS23530_1124)	-	1124603..1125229 (+)	627	WP_002983834.1	prepilin peptidase	-
MGAS23530_RS05475 (MGAS23530_1125)	rlmN	1125311..1126390 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS23530_RS05480 (MGAS23530_1126)	-	1126394..1127014 (-)	621	WP_002992791.1	YutD family protein	-
MGAS23530_RS05485 (MGAS23530_1127)	-	1127462..1128439 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
MGAS23530_RS05490 (MGAS23530_1128)	sepM	1128861..1129898 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS23530_RS05495 (MGAS23530_1129)	coaD	1129885..1130376 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS23530_RS05500 (MGAS23530_1130)	rsmD	1130366..1130905 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS23530_RS05505 (MGAS23530_1131)	asnA	1131028..1132020 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
MGAS23530_RS05510 (MGAS23530_1132)	arcC	1132333..1133283 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS23530_RS05515 (MGAS23530_1133)	-	1133303..1134634 (-)	1332	WP_063504952.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=165076 MGAS23530_RS05490 WP_010922499.1 1128861..1129898(-) (sepM) [Streptococcus pyogenes strain MGAS23530]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=165076 MGAS23530_RS05490 WP_010922499.1 1128861..1129898(-) (sepM) [Streptococcus pyogenes strain MGAS23530]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693