Detailed information NTG0165024

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS11027_RS05975
• Genome accession: NZ_CP013838
• Coordinates: 1203682..1204719 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS11027
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1198682..1209719

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS11027_RS05955 (MGAS11027_1215)	-	1199424..1200050 (+)	627	WP_002983834.1	prepilin peptidase	-
MGAS11027_RS05960 (MGAS11027_1216)	rlmN	1200132..1201211 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS11027_RS05965 (MGAS11027_1217)	-	1201215..1201835 (-)	621	WP_002992791.1	YutD family protein	-
MGAS11027_RS05970 (MGAS11027_1218)	-	1202283..1203260 (-)	978	WP_063510263.1	LacI family DNA-binding transcriptional regulator	-
MGAS11027_RS05975 (MGAS11027_1219)	sepM	1203682..1204719 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS11027_RS05980 (MGAS11027_1220)	coaD	1204706..1205197 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS11027_RS05985 (MGAS11027_1221)	rsmD	1205187..1205726 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS11027_RS05990 (MGAS11027_1222)	asnA	1205849..1206841 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
MGAS11027_RS05995 (MGAS11027_1223)	arcC	1207154..1208104 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS11027_RS06000 (MGAS11027_1224)	-	1208124..1209455 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=165024 MGAS11027_RS05975 WP_010922499.1 1203682..1204719(-) (sepM) [Streptococcus pyogenes strain MGAS11027]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=165024 MGAS11027_RS05975 WP_010922499.1 1203682..1204719(-) (sepM) [Streptococcus pyogenes strain MGAS11027]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693