Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | MGAS11027_RS05620 | Genome accession | NZ_CP013838 |
| Coordinates | 1129326..1131131 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain MGAS11027 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1109097..1156125 | 1129326..1131131 | within | 0 |
Gene organization within MGE regions
Location: 1109097..1156125
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MGAS11027_RS05530 (MGAS11027_1129) | - | 1109135..1110409 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| MGAS11027_RS05535 (MGAS11027_1130) | - | 1110504..1111931 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| MGAS11027_RS05540 (MGAS11027_1131) | ptsP | 1112116..1113849 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| MGAS11027_RS05545 (MGAS11027_1132) | - | 1113854..1114117 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| MGAS11027_RS05550 (MGAS11027_1133) | - | 1114510..1114728 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| MGAS11027_RS05555 (MGAS11027_1134) | nrdE | 1114748..1116907 (+) | 2160 | WP_031488773.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| MGAS11027_RS05560 (MGAS11027_1136) | nrdF | 1117240..1118199 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| MGAS11027_RS05565 (MGAS11027_1137) | - | 1118261..1119487 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| MGAS11027_RS09190 (MGAS11027_1138) | - | 1119583..1120739 (+) | 1157 | Protein_1082 | IS3 family transposase | - |
| MGAS11027_RS05585 (MGAS11027_1139) | - | 1120831..1121526 (-) | 696 | WP_063510258.1 | CPBP family intramembrane glutamic endopeptidase | - |
| MGAS11027_RS05590 (MGAS11027_1140) | - | 1121545..1122306 (-) | 762 | WP_031488552.1 | DUF3169 family protein | - |
| MGAS11027_RS05595 (MGAS11027_1141) | - | 1122303..1122518 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| MGAS11027_RS05600 (MGAS11027_1143) | alaS | 1122858..1125476 (-) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| MGAS11027_RS05605 (MGAS11027_1144) | prsA | 1125863..1126918 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| MGAS11027_RS05610 (MGAS11027_1145) | - | 1126981..1127688 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| MGAS11027_RS05615 (MGAS11027_1146) | - | 1127754..1128950 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| MGAS11027_RS05620 (MGAS11027_1147) | pepF | 1129326..1131131 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| MGAS11027_RS05625 (MGAS11027_1148) | - | 1131144..1132106 (-) | 963 | WP_053039058.1 | competence protein CoiA | - |
| MGAS11027_RS05630 (MGAS11027_1149) | - | 1132402..1133118 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| MGAS11027_RS05635 (MGAS11027_1150) | nagB | 1133237..1133941 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| MGAS11027_RS05640 (MGAS11027_1151) | queA | 1134143..1135171 (+) | 1029 | WP_031488549.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| MGAS11027_RS05645 (MGAS11027_1152) | - | 1135178..1136398 (+) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| MGAS11027_RS05650 (MGAS11027_1153) | - | 1136512..1137102 (-) | 591 | WP_002983984.1 | serine hydrolase | - |
| MGAS11027_RS09475 (MGAS11027_1154) | - | 1137099..1137326 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| MGAS11027_RS05660 (MGAS11027_1155) | - | 1137327..1137560 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| MGAS11027_RS05665 (MGAS11027_1156) | sodA | 1137727..1138332 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| MGAS11027_RS05670 (MGAS11027_1157) | holA | 1138429..1139469 (-) | 1041 | WP_031488548.1 | DNA polymerase III subunit delta | - |
| MGAS11027_RS05675 (MGAS11027_1158) | - | 1139540..1141783 (-) | 2244 | WP_031488547.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| MGAS11027_RS05680 (MGAS11027_1159) | - | 1141764..1142426 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| MGAS11027_RS05685 (MGAS11027_1161) | - | 1142626..1143366 (-) | 741 | WP_031488546.1 | lysophospholipid acyltransferase family protein | - |
| MGAS11027_RS05690 (MGAS11027_1160) | - | 1143484..1144260 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| MGAS11027_RS05695 (MGAS11027_1162) | - | 1144250..1144528 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| MGAS11027_RS05700 (MGAS11027_1163) | - | 1144552..1146552 (-) | 2001 | WP_053039059.1 | potassium transporter Kup | - |
| MGAS11027_RS05705 (MGAS11027_1164) | - | 1146679..1148298 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| MGAS11027_RS05710 (MGAS11027_1166) | - | 1148605..1150149 (-) | 1545 | WP_031488544.1 | peptide chain release factor 3 | - |
| MGAS11027_RS05715 (MGAS11027_1167) | - | 1150397..1151092 (-) | 696 | WP_031488543.1 | TIGR02206 family membrane protein | - |
| MGAS11027_RS05720 (MGAS11027_1168) | - | 1151172..1152563 (-) | 1392 | WP_031488542.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| MGAS11027_RS05725 (MGAS11027_1169) | - | 1152754..1153800 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| MGAS11027_RS05730 (MGAS11027_1170) | recR | 1153901..1154497 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| MGAS11027_RS09595 | - | 1154544..1154735 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| MGAS11027_RS05740 (MGAS11027_1171) | - | 1155294..1156073 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=165021 MGAS11027_RS05620 WP_011054652.1 1129326..1131131(-) (pepF) [Streptococcus pyogenes strain MGAS11027]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=165021 MGAS11027_RS05620 WP_011054652.1 1129326..1131131(-) (pepF) [Streptococcus pyogenes strain MGAS11027]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |