Detailed information NTG0163306

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AUC49_RS09655
• Genome accession: NZ_CP013619
• Coordinates: 1962028..1963071 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM1607
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1957028..1968071

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AUC49_RS09625 (AUC49_09600)	-	1957449..1958705 (-)	1257	WP_074347694.1	aminopeptidase	-
AUC49_RS09630 (AUC49_09605)	-	1958708..1958908 (-)	201	WP_000180460.1	DUF1128 family protein	-
AUC49_RS09635 (AUC49_09610)	-	1959055..1959519 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AUC49_RS09640 (AUC49_09615)	-	1959526..1959801 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AUC49_RS09645 (AUC49_09620)	-	1960079..1961296 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
AUC49_RS09650 (AUC49_09625)	vraR	1961409..1962038 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AUC49_RS09655 (AUC49_09630)	vraS	1962028..1963071 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AUC49_RS09660 (AUC49_09635)	liaF	1963068..1963769 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AUC49_RS09665 (AUC49_09640)	-	1963784..1964170 (-)	387	WP_001110182.1	hypothetical protein	-
AUC49_RS09670 (AUC49_09645)	map	1964387..1965145 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
AUC49_RS09680 (AUC49_09660)	-	1965729..1966715 (+)	987	WP_000999712.1	FUSC family protein	-
AUC49_RS09685 (AUC49_09665)	-	1966904..1967317 (-)	414	WP_025174370.1	hypothetical protein	-
AUC49_RS09690 (AUC49_09670)	-	1967346..1967456 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=163306 AUC49_RS09655 WP_001017131.1 1962028..1963071(-) (vraS) [Staphylococcus aureus strain RIVM1607]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=163306 AUC49_RS09655 WP_001017131.1 1962028..1963071(-) (vraS) [Staphylococcus aureus strain RIVM1607]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1