Detailed information NTG0163263

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AUC48_RS09820
• Genome accession: NZ_CP013616
• Coordinates: 1970454..1971497 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM1295
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1965454..1976497

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AUC48_RS09790 (AUC48_09760)	-	1965875..1967131 (-)	1257	WP_001793428.1	aminopeptidase	-
AUC48_RS09795 (AUC48_09765)	-	1967134..1967334 (-)	201	WP_000180460.1	DUF1128 family protein	-
AUC48_RS09800 (AUC48_09770)	-	1967481..1967945 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AUC48_RS09805 (AUC48_09775)	-	1967952..1968227 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AUC48_RS09810 (AUC48_09780)	-	1968505..1969722 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
AUC48_RS09815 (AUC48_09785)	vraR	1969835..1970464 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AUC48_RS09820 (AUC48_09790)	vraS	1970454..1971497 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AUC48_RS09825 (AUC48_09795)	liaF	1971494..1972195 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AUC48_RS09830 (AUC48_09800)	-	1972210..1972596 (-)	387	WP_001110182.1	hypothetical protein	-
AUC48_RS09835 (AUC48_09805)	map	1972813..1973571 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
AUC48_RS09845 (AUC48_09820)	-	1974155..1975141 (+)	987	WP_000999712.1	FUSC family protein	-
AUC48_RS09850 (AUC48_09825)	-	1975330..1975743 (-)	414	WP_025174370.1	hypothetical protein	-
AUC48_RS09855 (AUC48_09830)	-	1975772..1975882 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=163263 AUC48_RS09820 WP_001017131.1 1970454..1971497(-) (vraS) [Staphylococcus aureus strain RIVM1295]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=163263 AUC48_RS09820 WP_001017131.1 1970454..1971497(-) (vraS) [Staphylococcus aureus strain RIVM1295]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1