Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   SA40TW_RS00230 Genome accession   NZ_CP013182
Coordinates   48810..50159 (-) Length   449 a.a.
NCBI ID   WP_021758189.1    Uniprot ID   Q3YK46
Organism   Staphylococcus aureus strain SA40TW     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 40396..55440 48810..50159 within 0


Gene organization within MGE regions


Location: 40396..55440
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SA40TW_RS00190 (SA40TW_00170) mecA 40396..42405 (-) 2010 WP_063852655.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  SA40TW_RS00195 (SA40TW_00175) - 42502..43488 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  SA40TW_RS00200 (SA40TW_00180) - 43478..43720 (+) 243 Protein_33 type I restriction enzyme endonuclease domain-containing protein -
  SA40TW_RS00205 (SA40TW_00185) - 43711..45321 (-) 1611 Protein_34 IS1182 family transposase -
  SA40TW_RS00210 (SA40TW_00190) - 45370..45876 (-) 507 WP_001092195.1 DUF1643 domain-containing protein -
  SA40TW_RS00215 (SA40TW_00195) - 45909..46201 (-) 293 Protein_36 DUF960 family protein -
  SA40TW_RS00220 (SA40TW_00200) - 46288..46638 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SA40TW_RS00225 (SA40TW_00205) ccrB 47160..48788 (-) 1629 WP_021758188.1 cassette chromosome recombinase CcrB Machinery gene
  SA40TW_RS00230 (SA40TW_00210) ccrA 48810..50159 (-) 1350 WP_021758189.1 cassette chromosome recombinase CcrA Machinery gene
  SA40TW_RS00235 (SA40TW_00215) cch1 50393..52186 (-) 1794 WP_021758190.1 cassette chromosome replicative helicase -
  SA40TW_RS00240 (SA40TW_00220) ssb 52186..52479 (-) 294 WP_021758191.1 cassette chromosome ssDNA-binding protein -
  SA40TW_RS00250 (SA40TW_00230) - 52714..53855 (+) 1142 WP_089535815.1 IS3 family transposase -
  SA40TW_RS00255 (SA40TW_00235) - 53926..55440 (-) 1515 WP_021758193.1 hypothetical protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52568.15 Da        Isoelectric Point: 9.9150

>NTDB_id=160380 SA40TW_RS00230 WP_021758189.1 48810..50159(-) (ccrA) [Staphylococcus aureus strain SA40TW]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQVTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTSSDNQLKQKIKCPCCNATLTNMTVRKKNHILRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLHQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=160380 SA40TW_RS00230 WP_021758189.1 48810..50159(-) (ccrA) [Staphylococcus aureus strain SA40TW]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAGTAACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATTAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCGTTAGAAAAAAGAATCATATATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTATGTGATTTCAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YK46

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

98.218

100

0.982
  ccrA Staphylococcus aureus COL

74.61

100

0.746

Multiple sequence alignment