Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   SAST43_RS10175 Genome accession   NZ_CP012974
Coordinates   2020491..2021207 (+) Length   238 a.a.
NCBI ID   WP_000688498.1    Uniprot ID   Q2VG52
Organism   Staphylococcus aureus strain ST20130943     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2015491..2026207
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SAST43_RS10145 (SAST43_01992) - 2015707..2016333 (+) 627 WP_000522384.1 nitroreductase family protein -
  SAST43_RS10150 (SAST43_01994) - 2016694..2017479 (+) 786 WP_000867952.1 carbon-nitrogen family hydrolase -
  SAST43_RS14900 (SAST43_01995) hld 2018079..2018159 (-) 81 WP_000046022.1 delta-hemolysin -
  SAST43_RS10160 (SAST43_03446) agrB 2018449..2019018 (+) 570 WP_001105707.1 accessory gene regulator AgrB -
  SAST43_RS10165 (SAST43_01997) agrD 2019015..2019155 (+) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  SAST43_RS10170 agrC 2019180..2020472 (+) 1293 WP_062909808.1 quorum-sensing sensor histidine kinase AgrC -
  SAST43_RS10175 (SAST43_03447) agrA 2020491..2021207 (+) 717 WP_000688498.1 quorum-sensing response regulator AgrA Regulator
  SAST43_RS10180 - 2021279..2021388 (+) 110 Protein_1931 hypothetical protein -
  SAST43_RS10185 (SAST43_02001) - 2021576..2022535 (-) 960 WP_001253302.1 carbohydrate kinase family protein -
  SAST43_RS10190 (SAST43_02002) - 2022532..2024016 (-) 1485 WP_000141413.1 sucrose-6-phosphate hydrolase -
  SAST43_RS10195 (SAST43_02003) - 2024165..2025115 (-) 951 WP_000790323.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27933.91 Da        Isoelectric Point: 6.0927

>NTDB_id=158793 SAST43_RS10175 WP_000688498.1 2020491..2021207(+) (agrA) [Staphylococcus aureus strain ST20130943]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSRDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=158793 SAST43_RS10175 WP_000688498.1 2020491..2021207(+) (agrA) [Staphylococcus aureus strain ST20130943]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGCTTACAATTAT
TATCAAGAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCGCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q2VG52

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

99.58

100

0.996

Multiple sequence alignment