Detailed information NTG0157610

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACH32_RS02510
• Genome accession: NZ_CP012756
• Coordinates: 470475..471518 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JS395
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 465475..476518

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACH32_RS02480 (ACH32_02470)	-	465896..467152 (-)	1257	WP_001793983.1	aminopeptidase	-
ACH32_RS02485 (ACH32_02475)	-	467155..467355 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACH32_RS02490 (ACH32_02480)	-	467502..467966 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACH32_RS02495 (ACH32_02485)	-	467973..468248 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACH32_RS02500 (ACH32_02490)	-	468526..469743 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
ACH32_RS02505 (ACH32_02495)	vraR	469856..470485 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACH32_RS02510 (ACH32_02500)	vraS	470475..471518 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACH32_RS02515 (ACH32_02505)	liaF	471515..472216 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACH32_RS02520 (ACH32_02510)	-	472231..472617 (-)	387	WP_001110184.1	hypothetical protein	-
ACH32_RS02525 (ACH32_02515)	map	472834..473592 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACH32_RS02530 (ACH32_02520)	-	474123..475109 (+)	987	WP_000999713.1	FUSC family protein	-
ACH32_RS02535 (ACH32_02525)	-	475285..475701 (-)	417	WP_025174593.1	hypothetical protein	-
ACH32_RS02540 (ACH32_02530)	-	475730..475840 (-)	111	WP_031926705.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=157610 ACH32_RS02510 WP_001017131.1 470475..471518(-) (vraS) [Staphylococcus aureus strain JS395]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=157610 ACH32_RS02510 WP_001017131.1 470475..471518(-) (vraS) [Staphylococcus aureus strain JS395]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1