Detailed information NTG0157574

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: A9E87_RS08505
• Genome accession: NZ_CP015945
• Coordinates: 1912149..1914725 (+)
• Length: 858 a.a.
• NCBI ID: WP_010947476.1
• Uniprot ID: Q5ZUP3
• Organism: Legionella pneumophila strain C11_O
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1907149..1919725

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A9E87_RS08475 (A9E87_08475)	-	1907426..1907794 (-)	369	WP_010947470.1	iron-sulfur cluster assembly accessory protein	-
A9E87_RS08480 (A9E87_08480)	-	1907799..1908182 (-)	384	WP_010947471.1	iron-sulfur cluster assembly scaffold protein	-
A9E87_RS08485 (A9E87_08485)	-	1908179..1909312 (-)	1134	WP_016356931.1	IscS subfamily cysteine desulfurase	-
A9E87_RS08490 (A9E87_08490)	trmJ	1909317..1910090 (-)	774	WP_010947473.1	tRNA (cytosine(32)/uridine(32)-2'-O)-methyltransferase TrmJ	-
A9E87_RS08495 (A9E87_08495)	-	1910206..1910991 (+)	786	WP_010947474.1	inositol monophosphatase family protein	-
A9E87_RS08500 (A9E87_08500)	-	1911104..1912060 (-)	957	WP_010947475.1	S49 family peptidase	-
A9E87_RS08505 (A9E87_08505)	clpC	1912149..1914725 (+)	2577	WP_010947476.1	ATP-dependent chaperone ClpB	Regulator
A9E87_RS08510 (A9E87_08510)	-	1914817..1916127 (-)	1311	WP_010947477.1	lpg1751 family Dot/Icm T4SS effector	-
A9E87_RS08515 (A9E87_08515)	-	1916140..1916787 (-)	648	WP_010947478.1	lpg1752 family Dot/Icm T4SS effector	-
A9E87_RS08520 (A9E87_08520)	mpl	1917080..1918447 (-)	1368	WP_010947479.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
A9E87_RS08525 (A9E87_08525)	-	1918449..1919069 (-)	621	WP_010947480.1	hypothetical protein	-

Sequence

Protein

• Length: 858 a.a.
• Molecular weight: 95854.69 Da
• Isoelectric Point: 5.3669

>NTDB_id=157574 A9E87_RS08505 WP_010947476.1 1912149..1914725(+) (clpC) [Legionella pneumophila strain C11_O]
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITIEVTSEAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGDTIIVSYKDGVMEFYKQ

Nucleotide

• Length: 2577 bp

>NTDB_id=157574 A9E87_RS08505 WP_010947476.1 1912149..1914725(+) (clpC) [Legionella pneumophila strain C11_O]
ATGCGAATGGACAAACTAACATCAAAGTTTCAAATGGCACTTGCAGATGCCCAATCCCTGGCTTTAGGTAGAGACAATGG
ATTTATAGAACCAGAACATTTAATGAAGGCCTTGCTTGATCAGCAAGGTGGAAGTTGCAGACCTCTTCTCAGTAAAGCGG
GTGTTAATATACCACTATTAAGAACTTTAATTGACCAAGCTCTGGATAAACTACCTAAAGTATCAGGCACCGGAGGAGAT
ATTCACATATCTAATGCATTGAATAGACTACTTAACCTGACTGACAAATTATCGCAACAAAGAAAAGATAACTTTATTTC
AAGCGAGCTTTTTATATTAGCAGCGATAAATGAGGATAGTAACCTTGCAAAAATACTTAAACAAGCCGGGGGTGACAACA
AAGCAATTGAAAAAGCAATTGATGAGTTAAGAGGTGGAGAAACGGTTAATGATCCAAATGCAGAGGAACAGCGACAAGCC
CTTGAAAAATATACACTGGATCTGACTGAACGTGCCGAGCAAGGAAAATTGGATCCAGTTATTGGACGAGATGATGAAAT
CAGACGCACCATCCAGGTATTGCAAAGAAGAACTAAAAATAACCCTGTATTAATAGGTGAACCTGGTGTTGGTAAAACAG
CCATAGTAGAAGGTTTGGCACAACGAATTATTAATGGTGAAGTACCTGAAGGATTAAAGAATAAACGCTTACTGGCGCTG
GACATGGGTGCCTTGATCGCAGGTGCAAAATATCGTGGAGAGTTTGAAGAACGCTTAAAAGGGGTGCTTAATGATTTGGC
AAAACAAGAGGGTCAAATCATATTATTTATTGATGAATTACACACTATGGTTGGCGCTGGCAAGGCTGAAGGAGCTATGG
ATGCCGGGAATATGCTCAAGCCAGCATTAGCTAGAGGTGAATTGCATTGCATTGGGGCTACGACATTAGACGAATACCGA
CAATACATTGAAAAGGATGCTGCCCTTGAACGACGTTTTCAAAAAGTACTGGTCGATGAACCCAGTGTGGAAGACACTAT
CGCTATATTAAGGGGACTTAAGGAACGTTATGAAGTTCACCATGGAGTTGAAATTACAGATCCCGCTTTGGTTGCTGCAG
CAACGCTATCCCATCGTTACATCAGCGACCGTCAACTACCTGATAAAGCCATTGATTTAATTGACGAGGCCGCCAGCTTA
ATCCGGATGGAAATTGATTCAAAACCAGAAAGTATGGATAAACTGGAACGACGCTTGATTCAGCTAAAAATCGAGCGTGA
AGCATTGAAAAAGGAAAATGACGAAGCATCTAAAAAAAGACTTGTTGATTTACAAAAAAGTATCGATGAATTAGAGCAAA
ATTATTCAGACTTAGAAGAAATTTGGAAAGCTGAAAAAGCGACCATGCAAGGGTCCACTCAAATCAAAGAGGCACTTGAG
CAAGCCAAACTGGAAATGGAAACTGCAAGGAGAGCAGGAGATTTAAGTCGTATGTCCGAATTACAATATGGACGTATACC
CGAGTTGGAAAAAAGATTAAGCCAAGTCTCTTCCGTTGATGCTATGGAAACAAAGTTGGTACGCAATAAAGTCACCGAAG
ATGAGATCGCAGAAGTTGTTTCAAAATGGACAGGAATCCCAGTATCTAAAATGATGGAAGGAGAAAAGGAAAAACTGCTG
AAAATGGAAGAAGCTTTGCACAGTAGACTCATTGGCCAGAATGAAGCGGTGGATGCTGTTTCTAATGCCATAAGACGGTC
ACGCGCAGGCCTGTCTGATCCTAATCGTCCAATTGGTTCATTTCTTTTTCTGGGGCCAACTGGTGTGGGAAAAACTGAAC
TATGTAAAGCACTTGCTTCTTTTCTTTTTGATACGGAAGAGGCGATGGTGCGCATTGATATGTCTGAATTTATGGAAAAA
CACTCTGTTGCGCGCTTAATCGGAGCGCCTCCTGGCTATGTAGGATATGAGGAGGGTGGCTATTTAACTGAAGCAGTCAG
ACGCAGACCCTATTCTGTTATCTTACTTGATGAAGTAGAAAAAGCTCATACAGATGTATTTAATATTCTGCTTCAAGTGA
TGGATGATGGCCGTCTAACAGATGGTCAGGGACGTACTGTTGACTTTAGGAATACCGTTATTGTTATGACCTCTAATCTG
GGATCTCAACTCATTCAGGAAATGAGCAGCAAATTTAATTACGATGAGATTAAGGCTGCGGTAATGGATTTAGTCAGCCA
ACATTTCAGGCCTGAATTTATCAACAGAATTGATGAATCGGTGGTATTCCATTCCCTGACAAAAGAACAAATTGCAAAAA
TTGCAGCAATCCAGATTAACTATTTACATCATCGGCTGAAACAACAAAATATCACTATTGAAGTCACAAGTGAGGCTTTA
TCTCATTTGGCTGAAGCAGGTTTTGACCCGGTCTATGGTGCCCGCCCCCTAAAACGTACTATTCAGCAAAAATTAGAGAA
TCCACTAGCTCAATCATTATTGACTGGAAAATTTAAATCCGGGGATACCATTATTGTATCTTATAAAGATGGAGTAATGG
AATTTTACAAGCAATGA

Domains

Predicted by InterProScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-846)

• AAA lid domain (AAA_lid_9) (342-444)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-759)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-335)

3D structure

• AlphaFold DB: Q5ZUP3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.181	100	0.478
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.061	100	0.415
clpC	Lactococcus lactis subsp. cremoris KW2	46.31	80.536	0.373
clpE	Streptococcus mutans UA159	45.95	79.138	0.364
clpE	Streptococcus pneumoniae TIGR4	45.283	80.303	0.364
clpE	Streptococcus pneumoniae Rx1	45.283	80.303	0.364
clpE	Streptococcus pneumoniae D39	45.283	80.303	0.364
clpE	Streptococcus pneumoniae R6	45.283	80.303	0.364