Detailed information NTG0156548

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FORC27_RS10700
• Genome accession: NZ_CP012692
• Coordinates: 2093657..2094700 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FORC_027
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2088657..2099700

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FORC27_RS10670 (FORC27_2005)	-	2089078..2090334 (-)	1257	WP_001795108.1	aminopeptidase	-
FORC27_RS10675 (FORC27_2006)	-	2090337..2090537 (-)	201	WP_000180460.1	DUF1128 family protein	-
FORC27_RS10680 (FORC27_2007)	-	2090684..2091148 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FORC27_RS10685 (FORC27_2008)	-	2091155..2091430 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FORC27_RS10690 (FORC27_2009)	-	2091708..2092925 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
FORC27_RS10695 (FORC27_2010)	vraR	2093038..2093667 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
FORC27_RS10700 (FORC27_2011)	vraS	2093657..2094700 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FORC27_RS10705 (FORC27_2012)	liaF	2094697..2095398 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FORC27_RS10710 (FORC27_2013)	-	2095413..2095799 (-)	387	WP_001110179.1	hypothetical protein	-
FORC27_RS10715 (FORC27_2014)	map	2096016..2096774 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
FORC27_RS10725 (FORC27_2015)	-	2097305..2098291 (+)	987	WP_000999717.1	FUSC family protein	-
FORC27_RS10730 (FORC27_2016)	-	2098722..2099135 (-)	414	WP_001557448.1	hypothetical protein	-
FORC27_RS10735	-	2099164..2099274 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=156548 FORC27_RS10700 WP_001017131.1 2093657..2094700(-) (vraS) [Staphylococcus aureus strain FORC_027]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=156548 FORC27_RS10700 WP_001017131.1 2093657..2094700(-) (vraS) [Staphylococcus aureus strain FORC_027]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1