Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   RN80_RS02240 Genome accession   NZ_CP012646
Coordinates   423147..425579 (+) Length   810 a.a.
NCBI ID   WP_060627341.1    Uniprot ID   -
Organism   Streptococcus mitis strain KCOM 1350 (= ChDC B183)     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 418147..430579
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN80_RS02210 (RN80_02220) cbpD 418422..419531 (+) 1110 WP_060627338.1 choline binding-anchored murein hydrolase CbpD -
  RN80_RS02215 (RN80_02225) - 419783..420073 (+) 291 WP_045612468.1 thiamine-binding protein -
  RN80_RS02220 (RN80_02230) - 420036..420794 (+) 759 WP_161970147.1 ABC transporter permease -
  RN80_RS02225 (RN80_02235) - 420833..421840 (+) 1008 WP_060627339.1 ABC transporter substrate-binding protein -
  RN80_RS02230 (RN80_02240) - 421840..422568 (+) 729 WP_060627340.1 ABC transporter ATP-binding protein -
  RN80_RS02235 (RN80_02245) - 422687..423145 (+) 459 WP_001211265.1 CtsR family transcriptional regulator -
  RN80_RS02240 (RN80_02250) clpC 423147..425579 (+) 2433 WP_060627341.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  RN80_RS02245 (RN80_02255) - 425742..426782 (+) 1041 WP_060627342.1 AAA family ATPase -
  RN80_RS02250 (RN80_02260) pnuC 426792..427571 (+) 780 WP_060627343.1 nicotinamide riboside transporter PnuC -
  RN80_RS02255 (RN80_02265) - 427573..428346 (+) 774 WP_060627344.1 NUDIX domain-containing protein -
  RN80_RS02260 (RN80_02270) - 428414..428644 (-) 231 WP_049543241.1 hypothetical protein -
  RN80_RS02265 (RN80_02275) - 428923..429615 (+) 693 WP_060627345.1 hypothetical protein -
  RN80_RS02270 (RN80_02280) - 429742..430428 (+) 687 WP_060627346.1 YoaK family protein -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90237.01 Da        Isoelectric Point: 5.9316

>NTDB_id=155996 RN80_RS02240 WP_060627341.1 423147..425579(+) (clpC) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SHRLQVLFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMIILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKVKHVKSDDSGLSPADKALMDGKWKQATQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLETELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
DHMQEVVKIMVKPLVASLAEKGIDLKLQTSALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGELVAGSTLKIGV
KAGQLKFDIA

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=155996 RN80_RS02240 WP_060627341.1 423147..425579(+) (clpC) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTGGCTGGCCATTTTGGAGCTCGTTACCTAGA
GTCTTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTGGCAGGGGCGACTTTAAATGATTATCCATATGAGA
TGGACCGTTTAGAAGAGGTCGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTT
TCTCATCGTTTGCAGGTCCTTTTTGACGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGGTGCTAGGGACAGAGCA
TGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGAGCTGGTTTTTCTTATGAAGACA
AGAAAGATCAGGTCAAGATTGCTGCCCTACGTCGAAATCTAGAAGAACGAGCAGGTTGGACTCGTGAAGACCTCAAGGCT
CTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCTAATATGATGGGTATGCCCCAGACTCCGAGCGG
AGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAACCAGTCATCGGTCGGGACAAGG
AAATCTCGCGTATGATTCAAATTTTGAGTCGTAAGACCAAGAACAATCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAA
ACTGCTCTGGCGCTTGGTCTTGCCCAGCGTATTGCTAGTGGTGATGTACCTGCGGAAATGGCTAAGATGCGCGTGTTAGA
GCTTGATTTGATGAATGTCGTTGCAGGGACACGCTTCCGTGGTGACTTTGAAGAGCGCATGAATAATATCATCAAGGATA
TTGAAGAAGATGGCCAAGTAATCCTCTTTATCGATGAACTCCACACCATCATGGGTTCTGGTAGTGGAATTGACTCAACT
CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCGACTACTCAGGAAGAATA
TCAAAAACATATCGAAAAAGATGCGGCCCTTTCTCGTCGTTTCGCGAAAGTGACGATTGAAGAGCCAAGTGTTGCAGACA
GCATGATCATTTTGCAAGGTTTGAAGGCGACTTATGAGAAGCACCATCGTGTGCAAATCACAGATGAAGCGGTTGAAACA
GCTGTCAAGATGGCCCATCGTTACTTGACTAGTCGTCACTTGCCAGACTCTGCTATCGATCTCTTAGATGAGGCGGCAGC
AACAGTGCAAAATAAGGTAAAGCATGTAAAATCAGACGATTCAGGTTTGAGTCCAGCTGACAAGGCCTTAATGGATGGTA
AGTGGAAACAAGCTACTCAACTAATTGCTAAAGAAGAGGAAGTGCCTGTCTATAAAGACTTGGTGACAGAGTCTGATATT
TTGACCACCTTGAGTCGTTTGTCAGGTATCCCTGTTCAAAAATTGACACAAACAGATGCTAAGAAATACTTGAACTTGGA
AACAGAACTCCATAAACGTGTCATCGGTCAAGATCAAGCTGTTTCAAGCATTAGCCGTGCCATTCGCCGCAACCAGTCAG
GGATTCGCAGTCACAAGCGTCCGATTGGTTCCTTTATGTTCCTAGGGCCTACAGGTGTCGGTAAGACCGAATTAGCCAAG
GCTTTGGCAGAAGTTCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTTGCAGC
CAGTCGTCTCAACGGAGCTCCTCCAGGCTATGTGGGTTACGAAGAAGGTGGGGAGCTGACCGAGAAGGTTCGCAACAAAC
CATACTCTGTTCTCCTCTTTGACGAGGTAGAGAAGGCCCATCCAGACATCTTTAATGTTCTCTTGCAGGTCTTGGATGAT
GGTGTCTTGACAGATAGTAAAGGTCGCAAGGTTGACTTCTCAAACACCATTATTATCATGACGTCAAACTTGGGTGCGAC
AGCCCTTCGTGATGATAAAACAGTCGGCTTTGGGGCTAAGGATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT
TTGAAGAGCTGAAAAAGGCTTATAGACCGGAATTCATCAACCGTATTGATGAAAAGGTGGTCTTCCATAGCTTGTCTAGC
GACCATATGCAGGAAGTAGTGAAGATTATGGTTAAACCTTTAGTGGCAAGTTTGGCTGAAAAAGGTATTGACTTGAAATT
ACAAACTTCAGCACTGAAATTGTTGGCAAATCAAGGATATGACCCAGAGATGGGAGCTCGTCCACTTCGCAGAACCCTGC
AAACAGAAGTGGAGGATAAGTTGGCAGAACTTCTTCTCAAGGGAGAATTAGTGGCAGGTAGTACACTTAAGATTGGTGTC
AAAGCAGGCCAGTTAAAATTTGATATTGCATAA

Domains

Predicted by InterproScan.

Clp amino terminal domain, pathogenicity island component (Clp_N)

(103-139)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-797)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)

AAA lid domain (AAA_lid_9)

(370-439)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae TIGR4

98.642

100

0.986
  clpC Streptococcus pneumoniae Rx1

98.642

100

0.986
  clpC Streptococcus pneumoniae D39

98.642

100

0.986
  clpC Streptococcus mutans UA159

67.159

100

0.674
  clpC Streptococcus thermophilus LMD-9

66.216

100

0.665
  clpC Streptococcus thermophilus LMG 18311

66.093

100

0.664
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.975

100

0.501
  clpC Bacillus subtilis subsp. subtilis str. 168

45.241

99.877

0.452
  clpE Streptococcus mutans UA159

49.032

76.543

0.375
  clpE Streptococcus pneumoniae Rx1

46.975

77.531

0.364
  clpE Streptococcus pneumoniae D39

46.975

77.531

0.364
  clpE Streptococcus pneumoniae R6

46.975

77.531

0.364
  clpC Lactococcus lactis subsp. cremoris KW2

46.571

77.407

0.36

Multiple sequence alignment