Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   AMD33_RS06810 Genome accession   NZ_CP012588
Coordinates   1316418..1317494 (-) Length   358 a.a.
NCBI ID   WP_011681549.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain MN-BM-A01     
Function   processing of CSP (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1311102..1380665 1316418..1317494 within 0


Gene organization within MGE regions


Location: 1311102..1380665
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AMD33_RS06785 (AMD33_06770) - 1311126..1311908 (+) 783 WP_011226459.1 ABC transporter ATP-binding protein -
  AMD33_RS06790 (AMD33_06775) - 1312530..1314596 (-) 2067 WP_011681548.1 cation:proton antiporter -
  AMD33_RS06795 (AMD33_06780) - 1314605..1314847 (-) 243 WP_011226461.1 hypothetical protein -
  AMD33_RS06800 (AMD33_06785) - 1314844..1315392 (-) 549 WP_011226462.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  AMD33_RS06805 (AMD33_06790) - 1315389..1316333 (-) 945 WP_011226463.1 TIGR01212 family radical SAM protein -
  AMD33_RS06810 (AMD33_06795) sepM 1316418..1317494 (-) 1077 WP_011681549.1 SepM family pheromone-processing serine protease Regulator
  AMD33_RS06815 (AMD33_06800) coaD 1317472..1317969 (-) 498 WP_011681550.1 pantetheine-phosphate adenylyltransferase -
  AMD33_RS06820 (AMD33_06805) rsmD 1318003..1318542 (-) 540 WP_002951741.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  AMD33_RS06825 (AMD33_06810) trxB 1318693..1319613 (-) 921 WP_011226467.1 thioredoxin-disulfide reductase -
  AMD33_RS06830 (AMD33_06815) - 1319679..1319903 (-) 225 WP_014621911.1 DUF4059 family protein -
  AMD33_RS06835 (AMD33_06820) - 1320118..1320861 (-) 744 WP_014608652.1 amino acid ABC transporter ATP-binding protein -
  AMD33_RS06840 (AMD33_06825) - 1320861..1321607 (-) 747 WP_095559509.1 amino acid ABC transporter permease -
  AMD33_RS06845 (AMD33_06830) - 1322003..1322832 (-) 830 Protein_1333 transporter substrate-binding domain-containing protein -
  AMD33_RS06850 (AMD33_06835) - 1323292..1323525 (-) 234 WP_002947030.1 hypothetical protein -
  AMD33_RS06855 (AMD33_06840) dinB 1323823..1324926 (-) 1104 WP_014608654.1 DNA polymerase IV -
  AMD33_RS06860 (AMD33_06845) pflB 1325205..1327514 (+) 2310 WP_011226473.1 formate C-acetyltransferase -
  AMD33_RS06865 (AMD33_06850) - 1327781..1328563 (+) 783 WP_014727672.1 carbonic anhydrase -
  AMD33_RS06870 (AMD33_06855) - 1328614..1329066 (+) 453 WP_014608655.1 GNAT family N-acetyltransferase -
  AMD33_RS06875 (AMD33_06860) - 1329417..1329701 (-) 285 WP_014608656.1 restriction endonuclease subunit S -
  AMD33_RS12180 mobV 1329747..1330255 (-) 509 Protein_1340 MobV family relaxase -
  AMD33_RS06890 (AMD33_06875) - 1330700..1331455 (-) 756 WP_011681558.1 ABC transporter permease -
  AMD33_RS06895 (AMD33_06880) - 1331452..1332102 (-) 651 WP_011681559.1 ATP-binding cassette domain-containing protein -
  AMD33_RS06900 (AMD33_06885) - 1332305..1333261 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  AMD33_RS06905 (AMD33_06890) - 1333261..1334015 (-) 755 Protein_1344 CppA family protein -
  AMD33_RS06910 (AMD33_06895) - 1334297..1334659 (+) 363 WP_014608659.1 CPBP family intramembrane glutamic endopeptidase -
  AMD33_RS06915 (AMD33_06900) gla 1334746..1335609 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  AMD33_RS06920 (AMD33_06905) - 1335730..1337997 (+) 2268 WP_011681561.1 Xaa-Pro dipeptidyl-peptidase -
  AMD33_RS06925 (AMD33_06910) - 1338077..1338457 (-) 381 WP_002951783.1 hypothetical protein -
  AMD33_RS11050 - 1338582..1338845 (-) 264 WP_002945924.1 hypothetical protein -
  AMD33_RS06930 (AMD33_06915) - 1339167..1339463 (-) 297 WP_004197070.1 bacteriocin immunity protein -
  AMD33_RS06935 (AMD33_06920) - 1339628..1339834 (-) 207 WP_011681562.1 hypothetical protein -
  AMD33_RS06940 (AMD33_06925) - 1339865..1340554 (-) 690 WP_011681563.1 thioredoxin family protein -
  AMD33_RS10615 - 1340748..1342318 (+) 1571 WP_087009847.1 IS3-like element ISSth1b family transposase -
  AMD33_RS06955 (AMD33_06940) - 1342464..1342718 (-) 255 WP_014608660.1 Blp family class II bacteriocin -
  AMD33_RS12185 (AMD33_06945) - 1342969..1343370 (-) 402 WP_024703992.1 hypothetical protein -
  AMD33_RS06965 (AMD33_06950) - 1344375..1344605 (-) 231 WP_014608662.1 bacteriocin class II family protein -
  AMD33_RS06970 (AMD33_06955) - 1344961..1345161 (-) 201 WP_011681569.1 hypothetical protein -
  AMD33_RS06975 (AMD33_06960) - 1345180..1345356 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  AMD33_RS06980 (AMD33_06965) - 1345607..1346344 (+) 738 WP_011681571.1 LytR/AlgR family response regulator transcription factor -
  AMD33_RS11860 - 1346875..1347678 (+) 804 WP_224102945.1 ATP-binding protein -
  AMD33_RS06990 (AMD33_06975) - 1347696..1347857 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  AMD33_RS06995 (AMD33_06980) - 1347872..1349239 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein -
  AMD33_RS07000 (AMD33_06985) comA/nlmT 1349255..1351408 (-) 2154 WP_014727675.1 peptide cleavage/export ABC transporter Regulator
  AMD33_RS07005 (AMD33_06990) - 1352488..1354233 (-) 1746 WP_014727676.1 ABC transporter ATP-binding protein -
  AMD33_RS07010 (AMD33_06995) - 1354226..1355863 (-) 1638 WP_014727677.1 ABC transporter ATP-binding protein -
  AMD33_RS11865 (AMD33_07000) - 1356172..1356378 (-) 207 WP_002948879.1 hypothetical protein -
  AMD33_RS07020 (AMD33_07005) - 1356583..1357110 (-) 528 WP_014621925.1 VanZ family protein -
  AMD33_RS07025 (AMD33_07010) rlmN 1357112..1358221 (-) 1110 WP_100285012.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  AMD33_RS07030 (AMD33_07015) - 1358285..1359007 (-) 723 WP_011681580.1 YutD family protein -
  AMD33_RS07035 (AMD33_07020) - 1359062..1360417 (-) 1356 WP_014727679.1 bifunctional metallophosphatase/5'-nucleotidase -
  AMD33_RS12050 - 1360696..1360827 (-) 132 WP_258380174.1 hypothetical protein -
  AMD33_RS07040 (AMD33_07025) - 1361266..1362609 (-) 1344 WP_002948888.1 DEAD/DEAH box helicase -
  AMD33_RS07045 (AMD33_07030) mraY 1362684..1363706 (-) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  AMD33_RS07050 (AMD33_07035) pbp2X 1363708..1365975 (-) 2268 WP_041829325.1 penicillin-binding protein PBP2X -
  AMD33_RS07055 (AMD33_07040) ftsL 1365979..1366299 (-) 321 WP_014727681.1 cell division protein FtsL -
  AMD33_RS07060 (AMD33_07045) rsmH 1366302..1367252 (-) 951 WP_014727682.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  AMD33_RS11365 - 1367366..1368064 (-) 699 WP_014727683.1 hypothetical protein -
  AMD33_RS11870 (AMD33_07055) - 1368022..1368408 (-) 387 WP_014727684.1 hypothetical protein -
  AMD33_RS10635 - 1368525..1368773 (-) 249 WP_224102941.1 Wzz/FepE/Etk N-terminal domain-containing protein -
  AMD33_RS07080 (AMD33_07065) - 1369047..1369402 (-) 356 Protein_1380 DUF805 domain-containing protein -
  AMD33_RS11055 - 1369750..1369917 (-) 168 WP_153300736.1 hypothetical protein -
  AMD33_RS07085 (AMD33_07070) - 1370250..1371500 (-) 1251 WP_014608675.1 glutamate-5-semialdehyde dehydrogenase -
  AMD33_RS07090 (AMD33_07075) proB 1371502..1372305 (-) 804 WP_014608676.1 glutamate 5-kinase -
  AMD33_RS07095 (AMD33_07080) - 1372426..1374015 (-) 1590 WP_014608677.1 ABC transporter permease -
  AMD33_RS07100 (AMD33_07085) - 1374018..1374749 (-) 732 WP_014727686.1 ABC transporter ATP-binding protein -
  AMD33_RS07105 (AMD33_07090) - 1375024..1375755 (+) 732 WP_014608678.1 DUF554 domain-containing protein -
  AMD33_RS07110 (AMD33_07095) addA 1376107..1379760 (-) 3654 WP_014727687.1 helicase-exonuclease AddAB subunit AddA -

Sequence

Protein


Download         Length: 358 a.a.        Molecular weight: 39172.02 Da        Isoelectric Point: 9.3888

>NTDB_id=155623 AMD33_RS06810 WP_011681549.1 1316418..1317494(-) (sepM) [Streptococcus thermophilus strain MN-BM-A01]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK

Nucleotide


Download         Length: 1077 bp        

>NTDB_id=155623 AMD33_RS06810 WP_011681549.1 1316418..1317494(-) (sepM) [Streptococcus thermophilus strain MN-BM-A01]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(137-206)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

62.757

95.251

0.598

Multiple sequence alignment