Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   NX99_RS08840 Genome accession   NZ_CP015282
Coordinates   1894783..1896888 (+) Length   701 a.a.
NCBI ID   WP_002891663.1    Uniprot ID   J7TNC7
Organism   Streptococcus salivarius strain ATCC 27945     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1889783..1901888
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NX99_RS08805 (NX99_08660) - 1889788..1890420 (+) 633 WP_002884372.1 nicotinate-nucleotide adenylyltransferase -
  NX99_RS08810 (NX99_08665) yqeK 1890417..1891007 (+) 591 WP_022496426.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
  NX99_RS08815 (NX99_08670) rsfS 1891031..1891384 (+) 354 WP_014632696.1 ribosome silencing factor -
  NX99_RS08820 (NX99_08675) - 1891589..1892329 (+) 741 WP_022496427.1 class I SAM-dependent DNA methyltransferase -
  NX99_RS08825 (NX99_08680) - 1892336..1893427 (+) 1092 WP_084915365.1 nucleotidyltransferase -
  NX99_RS08830 (NX99_08685) - 1893569..1893823 (+) 255 WP_060971904.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
  NX99_RS08835 (NX99_08690) - 1893827..1894081 (+) 255 WP_060971903.1 Txe/YoeB family addiction module toxin -
  NX99_RS08840 (NX99_08695) clpE 1894783..1896888 (+) 2106 WP_002891663.1 AAA family ATPase Regulator
  NX99_RS10125 - 1897324..1897449 (+) 126 WP_002884447.1 hypothetical protein -
  NX99_RS08845 (NX99_08700) - 1897467..1898075 (+) 609 WP_002884297.1 DUF4230 domain-containing protein -
  NX99_RS09995 - 1898650..1898817 (+) 168 WP_014634940.1 hypothetical protein -
  NX99_RS08855 (NX99_08705) - 1898998..1899297 (-) 300 WP_014634939.1 hypothetical protein -
  NX99_RS08860 (NX99_08710) - 1899294..1899713 (-) 420 WP_037599159.1 HIT family protein -
  NX99_RS08865 (NX99_08715) pptA 1899778..1900509 (+) 732 WP_014634937.1 ABC transporter ATP-binding protein Regulator
  NX99_RS08870 (NX99_08720) pptB 1900509..1901543 (+) 1035 WP_371748832.1 ABC transporter permease Regulator

Sequence

Protein


Download         Length: 701 a.a.        Molecular weight: 77325.20 Da        Isoelectric Point: 4.6947

>NTDB_id=153077 NX99_RS08840 WP_002891663.1 1894783..1896888(+) (clpE) [Streptococcus salivarius strain ATCC 27945]
MNNNFNNMDDLFNQLMGNMGGYRSENRRYMINGREVTPEEFAIYRQTGQLPGNEGEAVNPTQQQGKGPKQDGILAKLGRN
LTEEAREGKLDPVIGRNKEIQEACEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEA
GTQYRGSFEENIQNLVNEVKEAGNIILFFDEIHQILGAGSTGDGQGSKGLADILKPALSRGELTVIGATTQDEYRNTILK
NAALARRFNEVKVNAPSAEDTFKILQGIRDLYEKHHNVILPDDVLKAAVDFSVQYIPQRSLPDKAIDLVDVTAAHLAAQH
PVTDVNAVEHEIEEEKAKQEAAAAKEDYEAALNAKVRIEELEKKIANHTADLKVTATVNDVAESVERMTGIPVSQMGATD
IERLKDMGHRLQTKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGTKDAIIRLDMS
EYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIVLLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVI
IATSNAGFGYEANLTEDADKPELMDRLKPYFRPEFLNRFNAVIEFSHLSKEDLSKIVDLMLVEVNKTLSKKDIDLAVSEA
AKEYMTEEGYDEVMGVRPLRRVVEQQIRDKVTDFHLDNLDAKHLEADMEDGVLVIKEKDAE

Nucleotide


Download         Length: 2106 bp        

>NTDB_id=153077 NX99_RS08840 WP_002891663.1 1894783..1896888(+) (clpE) [Streptococcus salivarius strain ATCC 27945]
ATGAACAACAACTTTAACAATATGGACGATCTTTTCAATCAATTGATGGGTAACATGGGTGGTTACCGTTCAGAAAACCG
TCGCTATATGATTAACGGTCGTGAAGTGACACCTGAAGAATTTGCGATTTACCGTCAAACAGGTCAATTGCCTGGTAATG
AAGGTGAAGCAGTGAACCCAACTCAACAACAAGGTAAAGGACCTAAACAAGATGGTATCCTTGCTAAACTTGGTCGTAAC
TTGACTGAAGAAGCTCGCGAAGGTAAATTGGATCCTGTTATCGGACGTAACAAAGAAATCCAAGAAGCTTGCGAAATCTT
GGCTCGTCGTACCAAGAATAACCCAGTCCTTGTCGGGGACGCTGGGGTTGGTAAAACAGCCGTAGTTGAAGGTTTGGCTC
AAGCCATCGTCAATGGTGATGTCCCAGCTGCTATCAAGAACAAGGAAATCATCTCAATTGATATTTCTGGACTTGAAGCT
GGTACTCAATACCGTGGTAGCTTTGAAGAAAACATTCAAAACTTGGTAAACGAAGTCAAAGAAGCTGGAAACATTATCCT
CTTCTTCGATGAAATCCACCAAATTCTTGGTGCCGGAAGCACTGGCGATGGTCAAGGGTCTAAAGGTCTTGCTGATATCT
TGAAACCAGCTCTTTCACGTGGTGAATTGACAGTGATTGGTGCAACAACTCAAGATGAATATCGTAACACTATCTTGAAG
AACGCTGCCCTAGCTCGTCGTTTCAACGAAGTTAAGGTCAATGCTCCTTCTGCTGAAGATACTTTCAAGATTCTCCAAGG
TATCCGTGATCTTTATGAAAAACACCACAATGTTATCTTGCCAGATGACGTCTTGAAAGCAGCGGTTGATTTCTCTGTAC
AATACATTCCACAACGTAGCTTGCCAGATAAGGCTATCGACCTTGTCGATGTAACAGCTGCTCACTTGGCTGCTCAACAC
CCAGTGACTGATGTGAATGCTGTTGAACATGAAATTGAAGAAGAAAAAGCTAAACAAGAAGCTGCAGCTGCCAAAGAAGA
CTACGAAGCAGCTCTAAACGCTAAGGTTCGTATTGAAGAACTTGAAAAGAAAATTGCTAACCATACAGCAGACCTTAAAG
TCACTGCAACTGTTAACGATGTGGCTGAGTCTGTAGAACGTATGACTGGTATTCCAGTGTCACAAATGGGTGCAACTGAT
ATCGAACGTTTGAAAGATATGGGTCACCGTTTGCAAACTAAAGTTATCGGTCAAGATAAAGCCGTTGAAGCAGTGGCACG
TGCCATCCGTCGTAACCGTGCAGGATTTGACGAAGGTAACCGTCCAATCGGTAGCTTCCTCTTTGTAGGACCTACTGGTG
TTGGTAAAACTGAGTTGGCTAAACAATTGGCTCTTGATATGTTCGGTACTAAAGATGCCATTATCCGTTTGGACATGTCA
GAATACAGCGACCGCACAGCCGTTTCTAAATTGATTGGTACAACAGCTGGTTATGTTGGTTATGATGACAATAGCAATAC
TTTGACAGAACGTGTTCGCCGTAACCCATACTCAATCGTTCTTCTCGACGAAATTGAAAAGGCTGACCCTCAAGTCATCA
CCCTTCTCCTCCAAGTTTTGGACGATGGTCGTTTGACAGATGGTCAAGGTAACACTGTAAACTTCAAGAATACTGTGATT
ATCGCAACTTCAAACGCAGGCTTTGGTTACGAAGCTAACTTGACAGAAGATGCTGATAAACCAGAACTTATGGATCGTTT
GAAACCTTACTTCCGTCCAGAATTCCTTAACCGTTTCAATGCTGTCATCGAATTCTCACACTTGAGCAAAGAAGATCTTT
CTAAGATTGTAGATCTTATGTTGGTTGAAGTTAACAAGACTCTTTCTAAGAAAGACATTGACTTGGCAGTTAGCGAAGCT
GCTAAAGAATACATGACTGAAGAAGGCTACGATGAAGTCATGGGTGTTCGTCCACTCCGTCGTGTGGTTGAACAACAAAT
CCGTGACAAAGTCACAGACTTCCACTTGGATAACCTTGATGCTAAACACTTAGAAGCTGATATGGAAGATGGTGTCTTGG
TTATCAAAGAAAAAGATGCTGAATAA

Domains

Predicted by InterProScan.

AAA lid domain (AAA_lid_9)

(257-351)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(608-678)

AAA domain (Cdc48 subfamily) (AAA_2)

(441-601)

ATPase family associated with various cellular activities (AAA) (AAA)

(116-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TNC7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

46.79

100

0.468
  clpC Lactococcus lactis subsp. cremoris KW2

48.706

93.723

0.456
  clpE Streptococcus pneumoniae D39

48.678

91.726

0.447
  clpE Streptococcus pneumoniae R6

48.678

91.726

0.447
  clpE Streptococcus pneumoniae TIGR4

48.678

91.726

0.447
  clpE Streptococcus pneumoniae Rx1

48.678

91.726

0.447
  clpC Bacillus subtilis subsp. subtilis str. 168

45.666

92.154

0.421
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

42.089

92.867

0.391
  clpC Streptococcus pneumoniae TIGR4

43.087

88.73

0.382
  clpC Streptococcus pneumoniae Rx1

43.087

88.73

0.382
  clpC Streptococcus pneumoniae D39

43.087

88.73

0.382
  clpC Streptococcus thermophilus LMD-9

43.436

88.017

0.382
  clpC Streptococcus thermophilus LMG 18311

42.973

88.302

0.379
  clpC Streptococcus mutans UA159

42.332

89.301

0.378