Detailed information NTG0152736

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: A4265_RS08510
• Genome accession: NZ_CP015238
• Coordinates: 1699471..1702026 (-)
• Length: 851 a.a.
• NCBI ID: WP_063632185.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NS53
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1694471..1707026

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A4265_RS08470 (A4265_08055)	-	1694737..1695225 (+)	489	WP_063629723.1	hypothetical protein	-
A4265_RS08480 (A4265_08060)	-	1695629..1695991 (+)	363	WP_020905578.1	DUF1492 domain-containing protein	-
A4265_RS08485 (A4265_08065)	-	1695966..1696334 (+)	369	WP_063632183.1	ArpU family phage packaging/lysis transcriptional regulator	-
A4265_RS08490 (A4265_08070)	-	1696378..1696563 (+)	186	WP_009880486.1	hypothetical protein	-
A4265_RS08495 (A4265_08075)	-	1696702..1696884 (+)	183	WP_012560491.1	hypothetical protein	-
A4265_RS08500 (A4265_08080)	-	1697042..1697734 (+)	693	WP_012560490.1	DUF3800 domain-containing protein	-
A4265_RS08505 (A4265_08085)	-	1698339..1699073 (+)	735	WP_063632184.1	hypothetical protein	-
A4265_RS08510 (A4265_08090)	hexA	1699471..1702026 (-)	2556	WP_063632185.1	DNA mismatch repair protein MutS	Machinery gene
A4265_RS09230 (A4265_08095)	-	1702013..1702219 (-)	207	WP_011055092.1	hypothetical protein	-
A4265_RS08520 (A4265_08100)	argR	1702362..1702799 (-)	438	WP_063632186.1	arginine repressor	-
A4265_RS08525 (A4265_08105)	argS	1703090..1704781 (+)	1692	WP_032464633.1	arginine--tRNA ligase	-
A4265_RS08530 (A4265_08110)	-	1704869..1705177 (+)	309	WP_032464634.1	bacteriocin immunity protein	-
A4265_RS08535 (A4265_08115)	-	1705204..1706076 (-)	873	WP_032464635.1	YitT family protein	-
A4265_RS08540 (A4265_08120)	-	1706119..1706997 (-)	879	WP_002991372.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95431.98 Da
• Isoelectric Point: 5.0214

>NTDB_id=152736 A4265_RS08510 WP_063632185.1 1699471..1702026(-) (hexA) [Streptococcus pyogenes strain NS53]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDISTGEFCVTDLADFAS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFNSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTTSNLSLVPEHFFRKA
TLKNSERYGTAELAKIESQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKTLATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIISVPSQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=152736 A4265_RS08510 WP_063632185.1 1699471..1702026(-) (hexA) [Streptococcus pyogenes strain NS53]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCCATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATATATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTGCGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCA
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGGAGTCTGTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTAACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGCAGTATTATTCGTACTGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAAGGAACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGCGGCATTAATAATCTAAAAATTGATT
ACAATAAAAAAGATGGATATTATTTCCACGTTACGACTTCAAATCTTAGCTTAGTGCCTGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAACGTTATGGAACAGCAGAATTGGCTAAGATTGAAAGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAACTTTGGCAACGGTGGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTGGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATATCAGTCCCTTCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain V (MutS_V) (599-785)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.21	100	0.712
mutS	Pseudomonas stutzeri strain ATCC 17587	37.5	100	0.377