Detailed information NTG0151505

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACO02_RS11575
• Genome accession: NZ_CP012120
• Coordinates: 2216863..2217906 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain USA300_2014.C02
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2211863..2222906

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACO02_RS11530 (ACO02_04115)	-	2212233..2212343 (+)	111	WP_001790257.1	hypothetical protein	-
ACO02_RS11535 (ACO02_1745)	-	2212372..2212785 (+)	414	WP_001549145.1	hypothetical protein	-
ACO02_RS11545 (ACO02_1746)	-	2213275..2214261 (-)	987	WP_000999713.1	FUSC family protein	-
ACO02_RS11560 (ACO02_1747)	map	2214789..2215547 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACO02_RS11565 (ACO02_1748)	-	2215764..2216150 (+)	387	WP_001110179.1	hypothetical protein	-
ACO02_RS11570 (ACO02_1749)	liaF	2216165..2216866 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACO02_RS11575 (ACO02_1750)	vraS	2216863..2217906 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACO02_RS11580 (ACO02_1751)	vraR	2217896..2218525 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
ACO02_RS11585 (ACO02_1752)	-	2218641..2219858 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACO02_RS11590 (ACO02_1753)	-	2220136..2220411 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACO02_RS11595 (ACO02_1754)	-	2220418..2220882 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACO02_RS11600 (ACO02_1755)	-	2221029..2221229 (+)	201	WP_000180461.1	DUF1128 family protein	-
ACO02_RS11605 (ACO02_1756)	-	2221232..2222488 (+)	1257	WP_078149050.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=151505 ACO02_RS11575 WP_001017131.1 2216863..2217906(+) (vraS) [Staphylococcus aureus strain USA300_2014.C02]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=151505 ACO02_RS11575 WP_001017131.1 2216863..2217906(+) (vraS) [Staphylococcus aureus strain USA300_2014.C02]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1