Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   AC806_RS05730 Genome accession   NZ_CP012047
Coordinates   1223913..1224956 (-) Length   347 a.a.
NCBI ID   WP_014124890.1    Uniprot ID   A0A2H6DQ50
Organism   Tetragenococcus halophilus strain MJ4     
Function   processing of CSP (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1153465..1228766 1223913..1224956 within 0


Gene organization within MGE regions


Location: 1153465..1228766
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AC806_RS05425 (AC806_05420) - 1154135..1154620 (-) 486 WP_041591822.1 ComE operon protein 2 -
  AC806_RS05430 (AC806_05425) - 1154651..1155259 (-) 609 WP_061840254.1 helix-hairpin-helix domain-containing protein -
  AC806_RS05435 (AC806_05430) - 1155355..1155966 (-) 612 WP_069028944.1 HAD-IA family hydrolase -
  AC806_RS05440 (AC806_05435) - 1156086..1157237 (-) 1152 WP_069028945.1 pyridoxal phosphate-dependent aminotransferase -
  AC806_RS05445 (AC806_05440) - 1157260..1157982 (-) 723 WP_069028946.1 amino acid ABC transporter ATP-binding protein -
  AC806_RS05450 (AC806_05445) - 1157975..1159444 (-) 1470 WP_069028947.1 ABC transporter substrate-binding protein/permease -
  AC806_RS05455 (AC806_05450) - 1159702..1160262 (-) 561 WP_069028948.1 DNA-3-methyladenine glycosylase I -
  AC806_RS05460 (AC806_05455) - 1160276..1160776 (-) 501 WP_069028949.1 GNAT family N-acetyltransferase -
  AC806_RS05465 (AC806_05460) - 1160890..1161558 (-) 669 WP_069028950.1 SDR family oxidoreductase -
  AC806_RS05470 (AC806_05465) rlmD 1161993..1163360 (-) 1368 WP_069028951.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  AC806_RS05475 (AC806_05470) - 1163496..1164530 (-) 1035 WP_069028952.1 diacylglycerol kinase -
  AC806_RS05480 (AC806_05475) gatB 1164540..1165970 (-) 1431 WP_014124842.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
  AC806_RS05485 (AC806_05480) gatA 1165971..1167440 (-) 1470 WP_069028953.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
  AC806_RS05490 (AC806_05485) gatC 1167440..1167745 (-) 306 WP_061840263.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
  AC806_RS05495 (AC806_05490) ligA 1167860..1169875 (-) 2016 WP_061840264.1 NAD-dependent DNA ligase LigA -
  AC806_RS05500 (AC806_05495) pcrA 1169891..1172140 (-) 2250 WP_069028954.1 DNA helicase PcrA -
  AC806_RS05505 (AC806_05500) - 1172346..1173707 (-) 1362 WP_069028955.1 transposase -
  AC806_RS05510 (AC806_05505) - 1173907..1175442 (+) 1536 WP_069028956.1 ClC family H(+)/Cl(-) exchange transporter -
  AC806_RS05515 (AC806_05510) - 1175607..1176362 (+) 756 WP_069028957.1 DeoR/GlpR family DNA-binding transcription regulator -
  AC806_RS05520 (AC806_05515) pfkB 1176359..1177273 (+) 915 WP_014124849.1 1-phosphofructokinase -
  AC806_RS05525 (AC806_05520) - 1177286..1179223 (+) 1938 WP_061840267.1 PTS fructose transporter subunit IIABC -
  AC806_RS12035 - 1179495..1179668 (+) 174 WP_014124851.1 SPJ_0845 family protein -
  AC806_RS05530 (AC806_05525) yihA 1179715..1180296 (-) 582 WP_014124852.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  AC806_RS05535 (AC806_05530) clpX 1180364..1181620 (-) 1257 WP_061840268.1 ATP-dependent Clp protease ATP-binding subunit ClpX -
  AC806_RS05540 (AC806_05535) tig 1181838..1183121 (-) 1284 WP_061840269.1 trigger factor -
  AC806_RS05545 (AC806_05540) - 1183248..1184171 (-) 924 WP_061840270.1 hypothetical protein -
  AC806_RS05550 (AC806_05545) - 1184191..1184811 (-) 621 WP_061840271.1 RDD family protein -
  AC806_RS05555 (AC806_05550) sppA 1184813..1185835 (-) 1023 WP_061840272.1 signal peptide peptidase SppA -
  AC806_RS05560 (AC806_05555) glmS 1186234..1188045 (+) 1812 WP_061840273.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
  AC806_RS05565 (AC806_05560) - 1188495..1188914 (-) 420 WP_014124859.1 OsmC family protein -
  AC806_RS05570 (AC806_05565) - 1189115..1190533 (-) 1419 WP_069028958.1 ISLre2 family transposase -
  AC806_RS05575 (AC806_05570) - 1190714..1191481 (+) 768 WP_014124860.1 tyrosine-protein phosphatase -
  AC806_RS11720 - 1191505..1191690 (+) 186 WP_014124861.1 hypothetical protein -
  AC806_RS05580 (AC806_05575) - 1191737..1192576 (-) 840 WP_373852589.1 amidohydrolase family protein -
  AC806_RS12310 - 1192588..1192932 (-) 345 WP_373852590.1 hypothetical protein -
  AC806_RS05585 (AC806_05580) thrC 1192946..1194427 (-) 1482 WP_069028959.1 threonine synthase -
  AC806_RS05590 (AC806_05585) queG 1194551..1195711 (+) 1161 WP_069028960.1 tRNA epoxyqueuosine(34) reductase QueG -
  AC806_RS05595 (AC806_05590) - 1195715..1196242 (-) 528 WP_069028961.1 ECF transporter S component -
  AC806_RS12120 - 1196255..1196452 (-) 198 WP_231960483.1 hypothetical protein -
  AC806_RS05600 (AC806_05595) - 1196421..1196918 (-) 498 WP_231960484.1 hypothetical protein -
  AC806_RS05605 (AC806_05600) - 1196915..1197406 (-) 492 WP_069028962.1 nucleoside 2-deoxyribosyltransferase -
  AC806_RS05610 (AC806_05605) lepA 1197588..1199417 (+) 1830 WP_069028963.1 translation elongation factor 4 -
  AC806_RS05615 (AC806_05610) - 1199583..1199939 (+) 357 WP_061840275.1 hypothetical protein -
  AC806_RS05625 (AC806_05620) - 1200030..1201186 (+) 1157 WP_371862654.1 IS3 family transposase -
  AC806_RS05630 (AC806_05625) - 1201475..1202605 (+) 1131 WP_014124870.1 AI-2E family transporter -
  AC806_RS05635 (AC806_05630) clpB 1202661..1205267 (-) 2607 WP_061840452.1 ATP-dependent chaperone ClpB -
  AC806_RS05640 (AC806_05635) - 1205354..1206382 (-) 1029 WP_373852594.1 lysylphosphatidylglycerol synthase transmembrane domain-containing protein -
  AC806_RS05645 (AC806_05640) pepT 1206460..1207689 (-) 1230 WP_061840454.1 peptidase T -
  AC806_RS05650 (AC806_05645) - 1207702..1208823 (-) 1122 WP_061840455.1 Nif3-like dinuclear metal center hexameric protein -
  AC806_RS05655 (AC806_05650) - 1208820..1209515 (-) 696 WP_061840456.1 tRNA (adenine(22)-N(1))-methyltransferase -
  AC806_RS05660 (AC806_05655) dnaI 1209697..1210623 (-) 927 WP_061840457.1 primosomal protein DnaI -
  AC806_RS05665 (AC806_05660) - 1210623..1212008 (-) 1386 WP_014124877.1 replication initiation and membrane attachment family protein -
  AC806_RS05670 (AC806_05665) nrdR 1212027..1212494 (-) 468 WP_014124878.1 transcriptional regulator NrdR -
  AC806_RS05675 (AC806_05670) coaE 1212636..1213232 (-) 597 WP_014124879.1 dephospho-CoA kinase -
  AC806_RS05680 (AC806_05675) mutM 1213229..1214077 (-) 849 WP_014124880.1 DNA-formamidopyrimidine glycosylase -
  AC806_RS05685 (AC806_05680) polA 1214092..1216737 (-) 2646 WP_014124881.1 DNA polymerase I -
  AC806_RS05690 (AC806_05685) - 1216901..1217581 (-) 681 WP_014124882.1 Bax inhibitor-1/YccA family protein -
  AC806_RS05695 (AC806_05690) - 1217574..1218044 (-) 471 WP_014124883.1 MaoC/PaaZ C-terminal domain-containing protein -
  AC806_RS05700 (AC806_05695) murC 1218124..1219461 (-) 1338 WP_069028964.1 UDP-N-acetylmuramate--L-alanine ligase -
  AC806_RS05705 (AC806_05700) - 1219563..1220024 (-) 462 WP_014124885.1 SprT family protein -
  AC806_RS05710 (AC806_05705) - 1220021..1222198 (-) 2178 WP_069028965.1 Tex family protein -
  AC806_RS05715 (AC806_05710) - 1222278..1223012 (-) 735 WP_014124887.1 metallophosphoesterase -
  AC806_RS05720 (AC806_05715) - 1223042..1223413 (-) 372 WP_014124888.1 VOC family protein -
  AC806_RS05725 (AC806_05720) - 1223427..1223810 (-) 384 WP_014124889.1 DUF1149 family protein -
  AC806_RS05730 (AC806_05725) sepM 1223913..1224956 (-) 1044 WP_014124890.1 SepM family pheromone-processing serine protease Regulator
  AC806_RS05735 (AC806_05730) coaD 1224946..1225440 (-) 495 WP_014124891.1 pantetheine-phosphate adenylyltransferase -
  AC806_RS05740 (AC806_05735) rsmD 1225443..1225997 (-) 555 WP_061840465.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  AC806_RS05745 (AC806_05740) - 1226031..1226345 (-) 315 WP_014124893.1 YlbG family protein -
  AC806_RS05750 (AC806_05745) - 1226335..1226760 (-) 426 WP_014124894.1 YlbF family regulator -
  AC806_RS05755 (AC806_05750) - 1226757..1227872 (-) 1116 WP_014124895.1 CAP-associated domain-containing protein -

Sequence

Protein


Download         Length: 347 a.a.        Molecular weight: 38257.23 Da        Isoelectric Point: 4.5199

>NTDB_id=150836 AC806_RS05730 WP_014124890.1 1223913..1224956(-) (sepM) [Tetragenococcus halophilus strain MJ4]
MKRDSLKKTLILLIIALAIFASVFLPLPYYIEKPGSTIELKDLITVNDKKDQEDGSFSLTSVGVQQASVVTAIKAKISPF
EELVSEEDLFGGASGEEYDQMQNYYMESSQNAAIQQALKLAKRPYNFEYKGVYVMNVMENSSFNGKIDVGDTVTKVDGKS
FDNNQDFMDYVQQKSIGDTVKVTYEHNDKTKKASGKLVELPSNQKAGIGITLVDHTDITSKDDIDFDVEDIGGPSAGLMF
TLEIYEQLTEEDLRKGKDIAGTGTIDEKGKVGRISGIDKKVASADEAGAQIFFAPNDTISKKVLKKNPGLKSNYQEAKET
ADSLDTDMKIVPVKTLQDAIDYLKQMD

Nucleotide


Download         Length: 1044 bp        

>NTDB_id=150836 AC806_RS05730 WP_014124890.1 1223913..1224956(-) (sepM) [Tetragenococcus halophilus strain MJ4]
ATGAAGCGTGATTCTTTAAAAAAAACGTTAATACTTTTGATCATTGCACTCGCTATTTTCGCGAGTGTCTTTTTACCTTT
ACCCTATTATATTGAAAAGCCCGGTTCTACAATTGAACTTAAAGATTTAATCACTGTTAATGATAAAAAAGACCAGGAAG
ATGGTTCTTTTTCCCTAACTTCGGTAGGTGTTCAGCAGGCTTCAGTTGTTACAGCAATAAAAGCAAAGATTTCTCCTTTT
GAAGAATTGGTTTCAGAAGAAGATCTTTTCGGTGGGGCGAGTGGTGAAGAATATGATCAGATGCAAAATTATTATATGGA
ATCCTCGCAAAACGCAGCGATTCAACAAGCGCTAAAGTTGGCAAAGCGCCCTTATAACTTTGAGTATAAGGGTGTTTATG
TGATGAATGTGATGGAAAATTCGAGCTTTAATGGAAAAATAGATGTTGGTGACACAGTAACGAAAGTCGATGGAAAAAGC
TTTGATAATAACCAGGATTTTATGGATTATGTTCAGCAAAAGTCAATTGGTGACACTGTAAAAGTAACTTATGAACATAA
TGATAAAACAAAGAAAGCTAGTGGCAAGCTGGTAGAACTACCAAGTAATCAAAAAGCAGGAATCGGCATTACTTTAGTAG
ATCACACAGATATTACTTCAAAAGACGATATTGATTTTGATGTAGAGGATATTGGCGGACCTTCTGCTGGTTTAATGTTT
ACACTAGAAATTTATGAACAACTGACTGAAGAAGATTTGAGAAAAGGAAAAGATATCGCAGGAACAGGTACCATTGATGA
AAAAGGCAAAGTCGGGCGAATCAGTGGTATTGACAAAAAAGTGGCCAGCGCAGATGAAGCAGGTGCGCAAATCTTTTTTG
CGCCCAATGATACAATAAGTAAAAAAGTATTAAAGAAAAACCCCGGCTTAAAATCTAACTATCAGGAAGCTAAAGAGACA
GCTGATAGTTTAGATACGGACATGAAAATCGTTCCGGTAAAAACCTTACAAGATGCTATTGATTATTTAAAACAGATGGA
TTAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-298)

PDZ domain (PDZ_2)

(130-194)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H6DQ50

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

50.149

96.542

0.484

Multiple sequence alignment