Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | SAHC1340_RS00430 | Genome accession | NZ_CP012011 |
| Coordinates | 90106..91452 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain HC1340 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 40891..91452 | 90106..91452 | within | 0 |
Gene organization within MGE regions
Location: 40891..91452
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAHC1340_RS00165 (SAHC1340_00646) | ccrC | 40891..42570 (+) | 1680 | WP_016187646.1 | cassette chromosome recombinase CcrC | - |
| SAHC1340_RS00170 (SAHC1340_00647) | - | 42659..42997 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| SAHC1340_RS00175 (SAHC1340_00649) | - | 43091..43402 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| SAHC1340_RS00180 (SAHC1340_00650) | - | 43418..43924 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| SAHC1340_RS00185 (SAHC1340_00651) | - | 43945..44262 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| SAHC1340_RS00190 (SAHC1340_02605) | - | 44381..45466 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| SAHC1340_RS16600 (SAHC1340_03283) | - | 45463..47364 (+) | 1902 | Protein_36 | site-specific integrase | - |
| SAHC1340_RS00200 (SAHC1340_00656) | - | 47371..47748 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| SAHC1340_RS16605 (SAHC1340_03284) | ant(9) | 47899..48682 (+) | 784 | Protein_38 | aminoglycoside nucleotidyltransferase ANT(9) | - |
| SAHC1340_RS00210 (SAHC1340_00659) | erm(A) | 48808..49539 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| SAHC1340_RS17140 | - | 49622..49681 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| SAHC1340_RS00215 (SAHC1340_00660) | - | 50073..50735 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| SAHC1340_RS15830 (SAHC1340_03289) | - | 50967..51113 (+) | 147 | Protein_42 | JAB domain-containing protein | - |
| SAHC1340_RS00220 (SAHC1340_00662) | - | 51283..52155 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| SAHC1340_RS00225 (SAHC1340_00663) | - | 52212..52502 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| SAHC1340_RS00230 (SAHC1340_00664) | - | 52518..53006 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| SAHC1340_RS00235 (SAHC1340_02775) | - | 53139..54311 (-) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| SAHC1340_RS00240 (SAHC1340_00666) | - | 54473..55000 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| SAHC1340_RS00245 (SAHC1340_00667) | - | 55062..55478 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| SAHC1340_RS00250 (SAHC1340_00669) | - | 55945..56166 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| SAHC1340_RS00255 (SAHC1340_00670) | - | 56302..56880 (+) | 579 | WP_020444591.1 | PepSY domain-containing protein | - |
| SAHC1340_RS00260 (SAHC1340_00671) | - | 56960..59173 (-) | 2214 | Protein_51 | type I restriction endonuclease subunit R | - |
| SAHC1340_RS00265 (SAHC1340_00672) | - | 59235..59909 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| SAHC1340_RS00270 (SAHC1340_03333) | - | 60192..61538 (+) | 1347 | WP_000163428.1 | dihydrolipoyl dehydrogenase family protein | - |
| SAHC1340_RS00275 (SAHC1340_03285) | merR | 61838..62245 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| SAHC1340_RS17125 | - | 62262..62616 (+) | 355 | Protein_55 | TlpA family protein disulfide reductase | - |
| SAHC1340_RS00285 (SAHC1340_00675) | - | 62613..63293 (+) | 681 | WP_000010351.1 | cytochrome c biogenesis CcdA family protein | - |
| SAHC1340_RS00290 (SAHC1340_00676) | - | 63428..63766 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| SAHC1340_RS00295 (SAHC1340_00677) | merA | 63824..65467 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| SAHC1340_RS00300 (SAHC1340_00678) | merB | 65549..66199 (+) | 651 | WP_059340799.1 | organomercurial lyase MerB | - |
| SAHC1340_RS00305 (SAHC1340_00679) | - | 66394..66924 (-) | 531 | WP_041205518.1 | hypothetical protein | - |
| SAHC1340_RS00310 (SAHC1340_00680) | - | 66960..67634 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| SAHC1340_RS15840 (SAHC1340_03329) | - | 67670..68059 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| SAHC1340_RS00320 (SAHC1340_00682) | - | 68976..69719 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| SAHC1340_RS00325 (SAHC1340_00683) | - | 69816..70244 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| SAHC1340_RS00330 (SAHC1340_00684) | mecA | 70290..72299 (-) | 2010 | WP_078056052.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| SAHC1340_RS00335 (SAHC1340_00685) | mecR1 | 72396..74153 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| SAHC1340_RS00340 | mecI | 74153..74524 (+) | 372 | Protein_67 | mecA-type methicillin resistance repressor MecI | - |
| SAHC1340_RS16620 | psm-mec | 74609..74677 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| SAHC1340_RS00345 (SAHC1340_00688) | - | 74997..76145 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| SAHC1340_RS00355 (SAHC1340_00690) | cstB | 76259..77593 (-) | 1335 | Protein_70 | persulfide dioxygenase-sulfurtransferase CstB | - |
| SAHC1340_RS00360 (SAHC1340_00691) | - | 77625..78689 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| SAHC1340_RS00365 (SAHC1340_00692) | cstR | 78825..79085 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| SAHC1340_RS00370 (SAHC1340_00693) | - | 79085..79723 (+) | 639 | Protein_73 | sulfite exporter TauE/SafE family protein | - |
| SAHC1340_RS00375 (SAHC1340_00694) | - | 79997..80614 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| SAHC1340_RS00380 (SAHC1340_00695) | - | 80695..83109 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| SAHC1340_RS00385 (SAHC1340_00696) | - | 83102..83467 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| SAHC1340_RS00390 (SAHC1340_00697) | - | 83705..84082 (-) | 378 | WP_000361060.1 | DUF6262 family protein | - |
| SAHC1340_RS00395 (SAHC1340_03281) | - | 84089..85981 (-) | 1893 | WP_020444597.1 | site-specific integrase | - |
| SAHC1340_RS00400 (SAHC1340_00700) | - | 86176..86499 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| SAHC1340_RS00405 (SAHC1340_00701) | - | 86492..86698 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| SAHC1340_RS00410 (SAHC1340_00702) | - | 86700..87221 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| SAHC1340_RS00415 (SAHC1340_00703) | - | 87240..87551 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| SAHC1340_RS00420 (SAHC1340_03312) | - | 87636..87986 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| SAHC1340_RS00425 (SAHC1340_00705) | ccrB | 88457..90085 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| SAHC1340_RS00430 (SAHC1340_00706) | ccrA | 90106..91452 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=150163 SAHC1340_RS00430 WP_000816499.1 90106..91452(-) (ccrA) [Staphylococcus aureus strain HC1340]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=150163 SAHC1340_RS00430 WP_000816499.1 90106..91452(-) (ccrA) [Staphylococcus aureus strain HC1340]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |