Detailed information NTG0147408

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AB179_RS10050
• Genome accession: NZ_CP011685
• Coordinates: 2000978..2002021 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ZJ5499
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1995978..2007021

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB179_RS10020 (AB179_10005)	-	1996399..1997655 (-)	1257	WP_001795108.1	aminopeptidase	-
AB179_RS10025 (AB179_10010)	-	1997658..1997858 (-)	201	WP_000180460.1	DUF1128 family protein	-
AB179_RS10030 (AB179_10015)	-	1998005..1998469 (+)	465	WP_042109418.1	low molecular weight protein-tyrosine-phosphatase	-
AB179_RS10035 (AB179_10020)	-	1998476..1998751 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AB179_RS10040 (AB179_10025)	-	1999029..2000246 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
AB179_RS10045 (AB179_10030)	vraR	2000359..2000988 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AB179_RS10050 (AB179_10035)	vraS	2000978..2002021 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AB179_RS10055 (AB179_10040)	liaF	2002018..2002719 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AB179_RS10060 (AB179_10045)	-	2002734..2003120 (-)	387	WP_001110179.1	hypothetical protein	-
AB179_RS10065 (AB179_10050)	map	2003337..2004095 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AB179_RS10075 (AB179_10060)	-	2004626..2005612 (+)	987	WP_000999717.1	FUSC family protein	-
AB179_RS10080 (AB179_10065)	-	2006043..2006456 (-)	414	WP_001557448.1	hypothetical protein	-
AB179_RS10085 (AB179_10070)	-	2006485..2006595 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=147408 AB179_RS10050 WP_001017131.1 2000978..2002021(-) (vraS) [Staphylococcus aureus strain ZJ5499]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=147408 AB179_RS10050 WP_001017131.1 2000978..2002021(-) (vraS) [Staphylococcus aureus strain ZJ5499]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1