Detailed information NTG0146659

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AA961_RS09430
• Genome accession: NZ_CP011528
• Coordinates: 1882729..1883772 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RKI4
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1877729..1888772

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AA961_RS09400 (AA961_09400)	-	1878151..1879407 (-)	1257	WP_001789555.1	aminopeptidase	-
AA961_RS09405 (AA961_09405)	-	1879410..1879610 (-)	201	WP_000180460.1	DUF1128 family protein	-
AA961_RS09410 (AA961_09410)	-	1879757..1880221 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AA961_RS09415 (AA961_09415)	-	1880228..1880503 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AA961_RS09420 (AA961_09420)	-	1880781..1881998 (+)	1218	WP_047928540.1	YihY/virulence factor BrkB family protein	-
AA961_RS09425 (AA961_09425)	vraR	1882110..1882739 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AA961_RS09430 (AA961_09430)	vraS	1882729..1883772 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AA961_RS09435 (AA961_09435)	liaF	1883769..1884470 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AA961_RS09440 (AA961_09440)	-	1884485..1884871 (-)	387	WP_001110179.1	hypothetical protein	-
AA961_RS09445 (AA961_09445)	map	1885088..1885846 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AA961_RS09450 (AA961_09450)	-	1886316..1887302 (+)	987	WP_047928543.1	FUSC family protein	-
AA961_RS09455 (AA961_09455)	-	1887733..1888146 (-)	414	WP_001670387.1	hypothetical protein	-
AA961_RS14950 (AA961_09460)	-	1888175..1888285 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=146659 AA961_RS09430 WP_001017131.1 1882729..1883772(-) (vraS) [Staphylococcus aureus strain RKI4]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=146659 AA961_RS09430 WP_001017131.1 1882729..1883772(-) (vraS) [Staphylococcus aureus strain RKI4]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1