Detailed information NTG0146618

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AA076_RS09835
• Genome accession: NZ_CP011526
• Coordinates: 1948756..1949799 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain DSM 20231
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1943756..1954799

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AA076_RS09805 (AA076_09805)	-	1944174..1945430 (-)	1257	WP_001795438.1	aminopeptidase	-
AA076_RS09810 (AA076_09810)	-	1945433..1945633 (-)	201	WP_000180461.1	DUF1128 family protein	-
AA076_RS09815 (AA076_09815)	-	1945780..1946244 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AA076_RS09820 (AA076_09820)	-	1946251..1946526 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AA076_RS09825 (AA076_09825)	-	1946804..1948021 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
AA076_RS09830 (AA076_09830)	vraR	1948137..1948766 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
AA076_RS09835 (AA076_09835)	vraS	1948756..1949799 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AA076_RS09840 (AA076_09840)	liaF	1949796..1950497 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AA076_RS09845 (AA076_09845)	-	1950512..1950898 (-)	387	WP_001110179.1	hypothetical protein	-
AA076_RS09850 (AA076_09850)	map	1951115..1951873 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AA076_RS09860 (AA076_09860)	-	1952401..1953387 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
AA076_RS09865 (AA076_09865)	-	1953877..1954290 (-)	414	WP_001549145.1	hypothetical protein	-
AA076_RS15290 (AA076_09870)	-	1954319..1954429 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=146618 AA076_RS09835 WP_001017131.1 1948756..1949799(-) (vraS) [Staphylococcus aureus strain DSM 20231]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=146618 AA076_RS09835 WP_001017131.1 1948756..1949799(-) (vraS) [Staphylococcus aureus strain DSM 20231]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1