Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   AA974_RS02425 Genome accession   NZ_CP011487
Coordinates   494524..496308 (-) Length   594 a.a.
NCBI ID   WP_064433274.1    Uniprot ID   -
Organism   Helicobacter pylori strain PNG84A     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 489524..501308
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AA974_RS02395 (AA974_02410) - 490051..490299 (+) 249 WP_000790557.1 RNA-binding protein -
  AA974_RS02400 (AA974_02415) - 490517..491338 (-) 822 WP_064433269.1 glycosyltransferase family 25 protein -
  AA974_RS02405 (AA974_02420) trxB 491552..492487 (-) 936 WP_064433270.1 thioredoxin-disulfide reductase -
  AA974_RS02410 (AA974_02425) trxA 492493..492813 (-) 321 WP_064433271.1 thioredoxin -
  AA974_RS02415 (AA974_02430) - 492902..493246 (-) 345 WP_064433272.1 YraN family protein -
  AA974_RS02420 (AA974_02435) - 493247..494512 (-) 1266 WP_064433273.1 homoserine dehydrogenase -
  AA974_RS02425 (AA974_02440) uvrC 494524..496308 (-) 1785 WP_064433274.1 excinuclease ABC subunit UvrC Machinery gene
  AA974_RS02430 (AA974_02445) - 496309..496770 (-) 462 WP_064433275.1 hypothetical protein -
  AA974_RS02435 (AA974_02450) - 496762..496941 (+) 180 WP_064433276.1 hypothetical protein -
  AA974_RS02440 (AA974_02455) - 496953..497594 (-) 642 WP_064433277.1 ATP-binding cassette domain-containing protein -
  AA974_RS02445 (AA974_02460) - 497596..499152 (-) 1557 WP_064433278.1 ABC transporter permease/substrate-binding protein -
  AA974_RS02450 (AA974_02465) - 499254..499691 (-) 438 WP_064433279.1 hypothetical protein -
  AA974_RS02455 (AA974_02470) motB 499695..500462 (-) 768 WP_064433280.1 flagellar motor protein MotB -
  AA974_RS02460 (AA974_02475) motA 500465..501238 (-) 774 WP_000366185.1 flagellar motor stator protein MotA -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68738.00 Da        Isoelectric Point: 9.6979

>NTDB_id=146299 AA974_RS02425 WP_064433274.1 494524..496308(-) (uvrC) [Helicobacter pylori strain PNG84A]
MAYLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNYRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQHSKKIALSVPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENNEFQKNSYRRYHLKGSDEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=146299 AA974_RS02425 WP_064433274.1 494524..496308(-) (uvrC) [Helicobacter pylori strain PNG84A]
ATGGCTTATTTATTGTCCAGTTTGAAAAACCTTTCTAACAGTAGCGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCTGTCCGTAATAATGAAATCACGCCCA
ATTATCGCGCCAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTAGAAAACGAACAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAACAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCCTACATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATAACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACAAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAGCAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCAATAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATCTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCATCAACACTCTAAAAAAATCGCTCTTAGTGTTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGAATTTCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTGATGAATACACTCAAATGAGCGAATTGCTCACTAGAAGGGCTTTAGATTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGAGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGATATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAGAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCTAGCGTGAAAAAATTGTTGGATTATTTCGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTGAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.643

100

0.976

Multiple sequence alignment