Detailed information NTG0145905

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: AA105_RS10185
• Genome accession: NZ_CP011419
• Coordinates: 2014006..2016459 (-)
• Length: 817 a.a.
• NCBI ID: WP_009910884.1
• Uniprot ID: A0A7Y6RRF0
• Organism: Streptococcus suis strain NSUI002
• Function: degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 2009006..2021459

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AA105_RS10170 (AA105_10180)	hslO	2011433..2012299 (+)	867	WP_013730589.1	Hsp33 family molecular chaperone HslO	-
AA105_RS10175 (AA105_10185)	dusB	2012292..2013296 (+)	1005	WP_009910879.1	tRNA dihydrouridine synthase DusB	-
AA105_RS10180 (AA105_10190)	-	2013397..2013888 (-)	492	WP_009910880.1	adenylyltransferase/cytidyltransferase family protein	-
AA105_RS10185 (AA105_10195)	clpC	2014006..2016459 (-)	2454	WP_009910884.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
AA105_RS10190 (AA105_10200)	-	2016463..2016915 (-)	453	WP_013730590.1	CtsR family transcriptional regulator	-
AA105_RS10195 (AA105_10205)	-	2017083..2017442 (+)	360	WP_013730591.1	bacteriocin transporter	-
AA105_RS10200 (AA105_10210)	-	2017514..2019382 (-)	1869	WP_013730592.1	Ig-like domain-containing protein	-
AA105_RS10205 (AA105_10215)	-	2019927..2021129 (+)	1203	WP_009909264.1	IS110-like element ISSsu7 family transposase	-

Sequence

Protein

• Length: 817 a.a.
• Molecular weight: 90461.93 Da
• Isoelectric Point: 6.0456

>NTDB_id=145905 AA105_RS10185 WP_009910884.1 2014006..2016459(-) (clpC) [Streptococcus suis strain NSUI002]
MKISTGLQRVFEDAQLVAQRYACDYLETWHVLLSFVINHDTVAGAVLAEYPISISDYEHATFVVTDKVYREELDSFRILP
SSKRLDETASFAKKIAEVVKAKELGTEHLFMAMLLDKRSTASQILDKVGFCFEDSDDKFRFLDLRKNLEARAGFTKEDLK
AIRSVMKGGKAKPTNMGQMMGMPPAPQSGGLEDYTRDLTALAREGKIEPVIGRDAEIARMIQILSRKTKNNPVLVGDAGV
GKTALALGLAQRVAAGDVPVSLAKMRVLELDLMNVIAGTRFRGDFEERMNNIINDIEEDGQVILFIDELHTIMGSGSGID
STLDAANILKPALARGTLRTVGATTQTEYQKHIEKDAALVRRFAKVTIEEPTVEDSIAILTGLKGTFEKYHRVRIGQAAV
ETAVTYAKRYLTSKNLPDSAIDLLDEASATVQNRVKGQGEETGLTSIDKALMDKKYKTVSKLLIETKEDAEASQNYDLEV
TEEDVLETLSRLSGIPVAKLSQSDTKKYLNLEAELHKRVIGQEEAISAVSRAIRRNQSGIRTGRRPIGSFMFLGPTGVGK
TELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLL
QVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGALDLSKDHKEVEKRIFEELKKAYRPEFINRIDEKVVF
HSLTETHMQDVVKVMIKPLLAVTAEKGITLKLQPSALKLLAKQGYDPEMGARPLRRLLQTKLEDPLAEMLLRGDLTTSST
LKVGVKGEELKFDVVKG

Nucleotide

• Length: 2454 bp

>NTDB_id=145905 AA105_RS10185 WP_009910884.1 2014006..2016459(-) (clpC) [Streptococcus suis strain NSUI002]
ATGAAAATTTCAACTGGTTTACAGCGGGTTTTTGAAGATGCCCAGTTAGTGGCTCAACGTTATGCCTGTGATTACTTGGA
AACCTGGCATGTTCTCTTGTCTTTCGTTATCAACCATGATACAGTCGCTGGCGCTGTTTTGGCAGAATATCCTATTTCAA
TTTCTGACTATGAACATGCAACTTTTGTTGTGACCGACAAGGTCTATCGTGAAGAGTTGGATAGTTTTCGTATTTTACCA
TCTTCTAAACGTTTGGATGAAACGGCTAGTTTTGCCAAGAAAATTGCAGAAGTCGTCAAGGCTAAGGAGCTGGGAACGGA
ACATTTGTTTATGGCTATGTTGTTGGACAAGCGGTCAACAGCTAGTCAGATTTTGGACAAGGTAGGTTTTTGTTTTGAAG
ACTCAGATGATAAGTTTCGTTTCTTGGATTTGCGTAAAAACTTGGAGGCACGTGCGGGATTTACCAAAGAGGACCTTAAA
GCTATCCGCAGTGTGATGAAGGGTGGCAAAGCCAAACCTACTAATATGGGACAGATGATGGGAATGCCCCCAGCACCTCA
AAGTGGTGGATTAGAAGACTACACTCGTGATTTGACAGCTTTGGCGCGTGAAGGGAAGATTGAACCTGTCATCGGTCGAG
ACGCTGAGATTGCACGGATGATCCAAATTCTATCACGTAAAACCAAGAATAACCCAGTTCTAGTTGGTGATGCTGGTGTC
GGAAAAACTGCGCTTGCTTTGGGTCTTGCTCAACGTGTTGCTGCAGGTGATGTCCCTGTCAGCTTGGCTAAGATGCGGGT
TTTGGAACTTGACTTGATGAACGTTATCGCTGGAACTCGTTTCCGTGGTGATTTCGAAGAGCGGATGAATAATATCATCA
ACGACATCGAGGAAGATGGTCAGGTCATCCTTTTCATCGATGAGTTGCATACCATTATGGGTTCTGGCTCAGGGATTGAT
TCGACCTTGGATGCAGCCAATATCCTCAAACCAGCTCTTGCTCGGGGCACCCTCCGTACGGTCGGAGCGACGACTCAGAC
AGAGTACCAAAAGCATATTGAGAAAGACGCAGCCCTGGTTCGTCGTTTTGCCAAAGTGACCATTGAAGAGCCGACAGTGG
AAGATAGCATTGCCATTTTGACTGGTTTAAAAGGTACTTTTGAAAAATACCACAGGGTCCGTATTGGACAAGCAGCTGTA
GAGACTGCTGTGACCTACGCTAAGCGGTATTTGACCAGTAAAAACCTGCCAGATTCTGCCATTGACTTGCTGGATGAAGC
CAGTGCAACGGTACAAAATCGAGTGAAAGGGCAGGGTGAGGAAACAGGACTGACGAGCATAGACAAGGCCTTGATGGATA
AAAAATATAAGACTGTCAGCAAGCTTTTGATTGAAACGAAAGAAGATGCCGAGGCTAGTCAAAACTATGACCTTGAAGTA
ACAGAAGAAGATGTTTTAGAAACACTTAGCCGCTTGTCAGGTATCCCAGTAGCCAAGCTTAGCCAATCAGATACTAAGAA
GTATCTGAATCTGGAAGCAGAATTGCACAAGCGTGTGATTGGGCAGGAAGAAGCTATTTCTGCAGTTAGCAGAGCTATTC
GCCGTAATCAGTCAGGGATTCGTACAGGTCGCAGACCGATTGGTTCCTTTATGTTCTTGGGACCAACTGGTGTCGGTAAG
ACAGAGCTTGCTAAAGCCTTGGCAGAGGTTCTCTTTGATGATGAATCTGCTCTTATCCGTTTTGATATGTCCGAGTATAT
GGAGAAATTTGCGGCCAGCCGTCTCAATGGAGCGCCTCCAGGTTATGTGGGCTATGAAGAAGGTGGCGAATTGACAGAAA
AAGTTCGTAACAAACCTTATTCTGTTCTTCTTTTTGATGAGGTTGAAAAGGCTCATCCAGATATTTTCAATGTTCTCTTG
CAGGTCTTGGATGATGGTGTTCTGACGGACAGTAAGGGACGTAAGGTTGATTTCTCAAATACTATTATTATCATGACGTC
AAACCTTGGAGCAACAGCTCTTCGTGATGATAAGACAGTTGGTTTTGGTGCCCTTGATTTATCTAAGGACCACAAGGAAG
TGGAGAAACGCATTTTTGAGGAATTGAAAAAAGCCTATCGTCCAGAATTTATCAACCGTATTGACGAGAAAGTTGTCTTC
CATAGCCTAACGGAAACTCATATGCAGGATGTTGTCAAGGTCATGATTAAACCTTTGTTGGCTGTAACAGCTGAGAAAGG
AATTACTCTTAAACTGCAACCGTCAGCCCTTAAGTTATTGGCTAAACAAGGTTATGACCCAGAAATGGGGGCTCGTCCGC
TACGTAGGCTCTTACAAACCAAATTGGAAGATCCGTTGGCAGAAATGTTACTCCGTGGTGACTTGACTACTAGTTCGACC
TTGAAGGTTGGGGTCAAGGGTGAAGAGCTCAAGTTTGATGTGGTAAAGGGATAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (233-365)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (102-129)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-56)

• AAA lid domain (AAA_lid_9) (372-455)

3D structure

• AlphaFold DB: A0A7Y6RRF0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae TIGR4	71.902	99.755	0.717
clpC	Streptococcus pneumoniae Rx1	71.902	99.755	0.717
clpC	Streptococcus pneumoniae D39	71.902	99.755	0.717
clpC	Streptococcus mutans UA159	66.339	99.633	0.661
clpC	Streptococcus thermophilus LMD-9	64.14	100	0.652
clpC	Streptococcus thermophilus LMG 18311	64.14	100	0.652
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.982	100	0.501
clpC	Bacillus subtilis subsp. subtilis str. 168	43.349	100	0.447