Detailed information NTG0144880

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: AXF35_RS08925
• Genome accession: NZ_CP014255
• Coordinates: 1945319..1947895 (+)
• Length: 858 a.a.
• NCBI ID: WP_027221935.1
• Uniprot ID: -
• Organism: Legionella pneumophila subsp. pascullei strain F-4185
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1940319..1952895

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AXF35_RS08895 (AXF35_07940)	-	1940588..1940953 (-)	366	WP_027221929.1	HesB/IscA family protein	-
AXF35_RS08900 (AXF35_07935)	-	1940958..1941341 (-)	384	WP_027221930.1	iron-sulfur cluster assembly scaffold protein	-
AXF35_RS08905 (AXF35_07930)	-	1941338..1942471 (-)	1134	WP_050598283.1	IscS subfamily cysteine desulfurase	-
AXF35_RS08910 (AXF35_07925)	trmJ	1942476..1943249 (-)	774	WP_027221932.1	tRNA (cytosine(32)/uridine(32)-2'-O)-methyltransferase TrmJ	-
AXF35_RS08915 (AXF35_07920)	-	1943365..1944150 (+)	786	WP_027221933.1	inositol monophosphatase family protein	-
AXF35_RS08920 (AXF35_07915)	-	1944274..1945230 (-)	957	WP_027221934.1	S49 family peptidase	-
AXF35_RS08925 (AXF35_07910)	clpC	1945319..1947895 (+)	2577	WP_027221935.1	ATP-dependent chaperone ClpB	Regulator
AXF35_RS08930 (AXF35_07905)	-	1947984..1949297 (-)	1314	WP_027221936.1	hypothetical protein	-
AXF35_RS08935 (AXF35_07900)	-	1949310..1949957 (-)	648	WP_080273054.1	lpg1752 family Dot/Icm T4SS effector	-
AXF35_RS08940 (AXF35_07895)	mpl	1950395..1951762 (-)	1368	WP_027221938.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
AXF35_RS08945 (AXF35_07890)	-	1951764..1952312 (-)	549	WP_027221939.1	hypothetical protein	-

Sequence

Protein

• Length: 858 a.a.
• Molecular weight: 95780.61 Da
• Isoelectric Point: 5.3657

>NTDB_id=144880 AXF35_RS08925 WP_027221935.1 1945319..1947895(+) (clpC) [Legionella pneumophila subsp. pascullei strain F-4185]
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFILAAISEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKAVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPSLVAAATLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFDYDQIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITLEVTNDAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGETIIVSYKDGVMEFSKQ

Nucleotide

• Length: 2577 bp

>NTDB_id=144880 AXF35_RS08925 WP_027221935.1 1945319..1947895(+) (clpC) [Legionella pneumophila subsp. pascullei strain F-4185]
ATGCGAATGGACAAACTAACATCAAAGTTTCAAATGGCTCTTGCAGATGCCCAATCCCTGGCCTTAGGTAGAGATAATGG
ATTTATAGAGCCAGAACATTTAATGAAAGCCTTACTCGATCAACAAGGTGGAAGTTGCAGACCTCTTCTTAGTAAAGCGG
GTGTTAATATACCACTATTAAGAACCTTAATTGACCAAGCTCTGGATAAACTCCCTAAAGTATCAGGTACCGGAGGCGAT
ATTCATATATCTAATGCGTTGAATAGACTACTTAACCTGACTGACAAATTATCGCAACAAAGAAAAGATAACTTTATTTC
AAGCGAGCTTTTTATATTAGCAGCGATAAGTGAGGATAGTAACCTTGCGAAAATCCTCAAACAAGCCGGAGGTGACAACA
AAGCCATTGAAAAGGCGATTGATGAGTTAAGAGGTGGAGAAACTGTTAATGATCCAAATGCAGAGGAACAGCGACAAGCC
CTTGAAAAATATACCCTGGATTTGACTGAACGTGCCGAACAAGGAAAACTGGATCCAGTTATTGGACGAGATGATGAAAT
TCGACGCACCATCCAGGTATTGCAAAGAAGAACTAAAAATAACCCTGTATTAATAGGTGAACCTGGTGTAGGTAAAACAG
CTATAGTGGAAGGTTTGGCGCAACGAATTATTAATGGTGAAGTGCCTGAAGGATTAAAGAATAAACGCTTACTGGCACTG
GACATGGGTGCATTGATTGCTGGTGCAAAATATCGCGGGGAGTTTGAAGAACGTTTAAAGGCAGTTCTTAATGATTTGGC
AAAACAAGAAGGTCAAATCATATTGTTTATTGATGAATTGCATACTATGGTCGGCGCTGGCAAGGCTGAAGGAGCTATGG
ATGCCGGGAATATGCTCAAACCAGCATTAGCTCGAGGTGAATTGCATTGCATCGGGGCTACCACATTAGACGAATACCGA
CAATATATTGAAAAAGATGCTGCCCTTGAAAGACGCTTTCAAAAAGTACTGGTCGATGAACCCAGTGTGGAAGACACCAT
TGCTATATTAAGGGGTCTTAAAGAACGGTATGAAGTTCACCATGGAGTTGAAATTACAGATCCTTCGTTGGTTGCTGCAG
CAACGCTATCCCATCGTTACATCAGCGACCGCCAACTACCCGACAAAGCCATTGATTTAATTGATGAAGCAGCCAGCTTA
ATCCGGATGGAAATTGATTCAAAACCTGAAAGTATGGATAAACTGGAACGACGTTTGATTCAGCTAAAAATCGAGCGTGA
AGCATTGAAAAAGGAAAATGATGAAGCGTCTAAAAAAAGACTTGTTGATTTACAAAAAAGTATCGATGAATTAGAGCAGA
ATTATTCAGACTTAGAGGAGATTTGGAAAGCTGAAAAGGCAACCATGCAAGGATCCACACAAATCAAGGAGGCACTTGAG
CAAGCCAAACTGGAAATGGAAACTGCCAGAAGAGCTGGAGATTTAAGTCGTATGTCTGAATTACAGTATGGTCGTATACC
TGAACTGGAAAAAAGATTAAGCCAGGTCTCTTCAGTCGATGCTATGGAAACAAAGTTGGTACGCAATAAAGTCACCGAAG
ATGAGATCGCAGAAGTTGTTTCAAAATGGACAGGGATCCCCGTATCTAAAATGATGGAGGGAGAAAAGGAAAAATTACTG
AAAATGGAAGAAGCTTTGCATAGCAGACTTATTGGCCAAAATGAAGCAGTAGATGCTGTTTCTAATGCCATAAGACGCTC
ACGTGCAGGGTTATCAGATCCCAATCGTCCCATTGGTTCGTTTCTTTTTCTGGGTCCAACCGGCGTAGGAAAAACCGAAT
TATGTAAAGCGCTAGCTTCTTTTCTTTTTGATACGGAAGAAGCTATGGTGCGCATTGATATGTCTGAATTTATGGAAAAA
CACTCTGTTGCACGCTTAATCGGCGCGCCTCCTGGCTACGTAGGATATGAAGAAGGTGGCTATTTAACTGAAGCAGTCAG
GCGCAAGCCCTATTCTGTTATCTTGCTCGATGAAGTAGAAAAAGCTCATACCGACGTATTTAATATTCTGCTTCAAGTTA
TGGATGATGGCCGTTTAACAGATGGTCAGGGACGTACTGTTGACTTTAGGAATACCGTTATTGTTATGACCTCTAATCTG
GGATCTCAACTGATTCAGGAAATGAGCAGCAAATTTGATTACGATCAGATTAAGGCTGCTGTAATGGATTTAGTCAGCCA
ACATTTTAGACCTGAATTTATCAACAGAATTGATGAATCGGTGGTATTCCATTCCTTGACAAAAGAACAAATTGCAAAAA
TTGCTGCAATCCAAATTAACTACTTGCATCATCGTCTGAAACAACAAAACATTACTCTTGAAGTCACAAATGACGCTTTA
TCTCATTTGGCTGAAGCAGGTTTTGATCCGGTCTATGGTGCCCGCCCCTTAAAACGTACCATTCAGCAAAAATTAGAGAA
TCCACTGGCGCAATCATTATTGACTGGAAAATTCAAATCAGGGGAAACCATTATTGTATCCTATAAAGATGGAGTAATGG
AATTTTCCAAGCAATGA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (342-444)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-335)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-759)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-846)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	46.951	100	0.476
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.187	81.002	0.374
clpC	Lactococcus lactis subsp. cremoris KW2	46.31	80.536	0.373
clpE	Streptococcus mutans UA159	45.95	79.138	0.364
clpE	Streptococcus pneumoniae TIGR4	45.283	80.303	0.364
clpE	Streptococcus pneumoniae Rx1	45.283	80.303	0.364
clpE	Streptococcus pneumoniae D39	45.283	80.303	0.364
clpE	Streptococcus pneumoniae R6	45.283	80.303	0.364